Qi
Wow. Admire the resilience and composure! Keep at it man.
I'm reading this book right now called the Dating Play Book for Men, and there's some good stuff in there about daytime cold approaches. Good book so far tbh. I haven't been as prolific as you in making approaches, but I've made a few here and there that went decently well. No overt indicators of disgust or contempt anyway.. mostly just polite rejections. WHICH IS A START!
Some things I've learned already that may apply: Maybe change up the opener? Look up a few good ones online, or personalize them a bit to the individual girl (like a mini-cold read). Also, what's your specific condition physically? Maybe tailoring your style of approach or 'vibe' to match your look could help some. Like bigger guys can use humor and come off as 'light' and 'funny' and not overly invested in the outcome, to diffuse some of the inherent fear caused by the size mismatch (only works if you're naturally funny and chill though). Or more emo guys could play it 'cool' and sorta 'over it'.. like stoic indifference. Like you're just commenting on something interesting or deep you observed and she just happens to be standing there. Nerdy guys could have an interesting book in hand that could spark a conversation, or comment and show interest in something she's reading etc etc..