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The Shay Files: "Mental Illness"

1714931914317

1714931941771
 
Bro @Intellau_Celistic you looked normal responing here what happened to you man
 
It isn't of value anyway.
 
Table 2. Individual FH Variants (≥30 carriers) Associated With Elevated maxLDL-C Among 331 107 Multiethnic Veterans



SNP IDChr: Basepair PositionGeneEffective AlleleAmino Acid SubstitutionNo.of CarriersBeta±SEP ValuemaxLDL≥190 (%)
rs1415020021:55524222PCSK9TArg469Trp11479.4±1.13.71×10–1717.9
rs127135592:21229068APOBAArg3558Cys3669.9±2.06.32×10–715.3
rs57429042:21229160APOBTArg3527Gln25643.5±2.43.40×10–7542.2
rs76856300019:11217264LDLRAGlu240Ter3420.3±6.51.8×10–326.5
rs15120712219:11218157LDLRTArg303Trp4936.2±5.42.16×10–1136.7
rs12190803019:11218160LDLRAAsp304Tyr3080.2±6.94.67×10–3166.7
rs20157386319:11231154LDLRTPro699Leu5144.0±5.31.03×10–1651.0
rs13785396419:11240278LDLRAVal827Ile32812.6±2.11.67×10–918.0



Background: Familial hypercholesterolemia (FH) is characterized by inherited high levels of LDL-C (low-density lipoprotein cholesterol) and premature coronary heart disease. Over a thousand low-frequ
www.ahajournals.org




Rarity One






Rarity Two





Rarity Three







PopulationGroupSample SizeRef AlleleAlt
PopulationGroupSample SizeRef AlleleAlt Allele
Total Global199288C=0.999729T=0.000271
European Sub169946C=0.999953T=0.000047
African Sub4954C=0.9923T=0.0077
African Others Sub176C=1.000T=0.000
African American Sub4778C=0.9920T=0.0080
Asian Sub6350C=0.9998T=0.0002
East Asian Sub4502C=0.9998T=0.0002
 

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