Nordcel9588
IncellianPerspective: A pagan unable to reproduce
★★★★
- Joined
- Jan 29, 2019
- Posts
- 350
So I just had a short discussion with my mother, and told her (again) that the true reason for my depression is that I was cursed with bad genetics that makes me invisible to most women, and once again she cannot seem to comprehend that.
It goes like this:
>I'm alone because I'm below 6 feet with an unattractive face and small dick
"No, you're not you just need to do something that helps your confidence"
>Bitch the reason I have low confidence is because I get rejected in every area of life BECAUSE of things I cannot change because they are a direct result of my fucking genetics.
"Your extra weight have nothing to do with genetics"
>Where the fuck did I talk about weight? And in my instance you're absolutely wrong. Because every time I work out, I always get exercise related damages because of my weak bones, that I got as a direct result of the ritalin she puts me on. It's clinically proven.
"No it's not"
>Abstract
It is well known that patients with attention deficit hyperactivity disorder treated with stimulants, such as methylphenidate hydrochloride (MPH), have reduced height and weight. Even though MPH has an anorexigenic effect, an additional impact of this drug on the growth plate cannot be discarded. In this study, we aimed to determine the cellular effect of MPH on an in vitro growth plate model. We tested the effects of MPH on the viability and proliferation of a prechondrogenic cell line via an MTT assay. In vitro differentiation of this cell line was performed, and cell differentiation was evaluated through the expression of cartilage- and bone-related genes as measured via RT-PCR. MPH did not alter the viability or proliferation of prechondrogenic cells. However, it reduced the expression of cartilage extracellular matrix-related genes (type II collagen and aggrecan) and increased the expression of genes involved in growth plate calcification (Runx2, type I collagen, and osteocalcin) at different phases of their differentiation process. Our results evidence that MPH upregulates genes associated with growth plate hypertrophic differentiation. This may induce premature closure of the growth plate, which would contribute to the growth retardation that has been described to be induced by this drug.
She then calls me an asshole and hangs up. I'm suffering because of things I cannot change and things she did that fucked me even further, and according to her, it's my fault.
When you get old I won't visit you when you get abused in the fucking nursing home. BITCH
It goes like this:
>I'm alone because I'm below 6 feet with an unattractive face and small dick
"No, you're not you just need to do something that helps your confidence"
>Bitch the reason I have low confidence is because I get rejected in every area of life BECAUSE of things I cannot change because they are a direct result of my fucking genetics.
"Your extra weight have nothing to do with genetics"
>Where the fuck did I talk about weight? And in my instance you're absolutely wrong. Because every time I work out, I always get exercise related damages because of my weak bones, that I got as a direct result of the ritalin she puts me on. It's clinically proven.
"No it's not"
>Abstract
It is well known that patients with attention deficit hyperactivity disorder treated with stimulants, such as methylphenidate hydrochloride (MPH), have reduced height and weight. Even though MPH has an anorexigenic effect, an additional impact of this drug on the growth plate cannot be discarded. In this study, we aimed to determine the cellular effect of MPH on an in vitro growth plate model. We tested the effects of MPH on the viability and proliferation of a prechondrogenic cell line via an MTT assay. In vitro differentiation of this cell line was performed, and cell differentiation was evaluated through the expression of cartilage- and bone-related genes as measured via RT-PCR. MPH did not alter the viability or proliferation of prechondrogenic cells. However, it reduced the expression of cartilage extracellular matrix-related genes (type II collagen and aggrecan) and increased the expression of genes involved in growth plate calcification (Runx2, type I collagen, and osteocalcin) at different phases of their differentiation process. Our results evidence that MPH upregulates genes associated with growth plate hypertrophic differentiation. This may induce premature closure of the growth plate, which would contribute to the growth retardation that has been described to be induced by this drug.
Methylphenidate Promotes Premature Growth Plate Closure: In Vitro Evidence
It is well known that patients with attention deficit hyperactivity disorder treated with stimulants, such as methylphenidate hydrochloride (MPH), have reduced height and weight. Even though MPH has an anorexigenic effect, an additional impact of this drug on the growth plate cannot be...
www.mdpi.com
She then calls me an asshole and hangs up. I'm suffering because of things I cannot change and things she did that fucked me even further, and according to her, it's my fault.
When you get old I won't visit you when you get abused in the fucking nursing home. BITCH