The short answer is no. You might feel more creative, but technically speaking because the brain gets input from both eyes and the messages cross before arriving at the occipital lobe, the main thing you would accomplish occluding one eye (assuming that initially this eye was seeing as well as the other) is your eye will tend to drift. The brain requires very closely similar images (congruent) in order to be able to keep the eyes focucsed and the central part of vision (the fovea) centered. In absence of this feedback from both eyes the unused eye will drift (and in most cases turn out) at first this turning will be very subtle, but can worsen over time to become noticeable.
