Yes.
The world's most popular sugar substitute has been linked to cancer, cardiovascular disease, Alzheimer’s disease, seizures, stroke, and weight gain. Yet regulatory agencies insist it is safe.
usrtk.org
Funny how buried this article is in the results too.
The Story of How Fake Sugar Got Approved is Scary As Hell; It involves Donald Rumsfeld,” by Kristin Wartman Lawless,
Vice (4.19.2017)
There's an unsettling story behind how it did.
www.vice.com
I have personally had an immediate adverse reaction to drinking a soda with aspartame a long time ago and never drink it since.