When you really sit down and think about it, internet ad space is perhaps the most valuable entity in the universe right now. More than gold, oil or whatever.
Internet advertisers have the power to dictate who sees what, what news you receive, the media you can enjoy, the games you play and even the UI. Creative thought and community have all been abandoned in order to cater to adspace, as advertisers will select and restrict content by regions in order to form the opinions of the people.
Using adblock isn't only convenient, it's necessary and vital, perhaps the biggest form of online rebellion next to not using the internet at all. Which is why more and more websites are violently cracking down on it, such as YouTube. You essentially rob them of the most powerful entity in existence as of now.
This should be enough of a reason to have 5 adblockers running.