Any schizoid cels

[The Incel Decade]

Schizoid personality disorder (/ˈskɪtsɔɪd, ˈskɪdzɔɪd/, often abbreviated as SPD or SzPD) is a personality disorder characterized by a lack of interest in social relationships, a tendency towards a solitary or sheltered lifestyle, secretiveness, emotional coldness, detachment and apathy. Affected individuals may be unable to form intimate attachments to others and simultaneously possess an elaborate imagination. Other associated features include stilted speech, a lack of deriving enjoyment from most activities, feeling as though one is an "observer" rather than a participant in life

Schizoid personality disorder - Wikipedia

en.wikipedia.org

I can relate to this a lot.

 

[Musophobia]

I was diagnosed with it years ago but I don't think I have it

 

[The Incel Decade]

I was diagnosed with it years ago but I don't think I have it

It reads like a textbook case for me but never been diagnosed

 

[RemoveNormalfags]

Not me

 

[Musophobia]

It reads like a textbook case for me but never been diagnosed

You can try going to a psychologist, for diagnosis if you want to

 

[78980n]

I can relate to it in some parts but I do not have it. By the way where has @Schizoidcel been?

 

[Pinpoint]

Despite of notoriety, no, well, maybe

 

[Deleted member 101]

2 1 S T C E N T U R Y S C H I Z O I D M A N

 

[Intellau_Celistic]

 

[Intellau_Celistic]

...

 

[Intellau_Celistic]

...

The Psychiatric Risk Gene Transcription Factor 4 (TCF4) Regulates Neurodevelopmental Pathways Associated With Schizophrenia, Autism, and Intellectual Disability​

Genetic variants in and around the transcription factor 4 (TCF4) gene are associated with range of disorders that are frequently associated with cognitive dysfunction.1–3 The most recent schizophrenia GWAS reported three independent single nucleotide polymorphisms (SNPs) in TCF4 that surpassed the threshold for genome wide significance.4 Intriguingly, rare TCF4 single nucleotide variants (SNVs) have also been described in schizophrenia patients, although their impact on the function of the protein has not been established.5,6 In addition to the genetic studies in schizophrenia, TCF4 variants are associated with early information processing and cognitive markers, some of which are schizophrenia endophenotypes.7–10 Damaging TCF4 mutations have also been described in large-scale genotyping studies in patients with ID, neurodevelopmental disorders, and most recently ASD.11–15 Haploinsufficiency of TCF4 causes Pitt–Hopkins syndrome (PTHS); a rare form intellectual disability (ID) associated with characteristic facial features, autonomic dysfunction, and behavioral traits that resemble autism spectrum disorder (ASD).16–19 Collectively, these studies implicate TCF4 in a range of neurodevelopmental disorders.

CF4 is a member of the basic helix-loop-helix (bHLH) family of proteins.20–22 For the purposes of disambiguation, it should be noted that TCF4 (Gene ID: 6925) described herein should not be confused with T-cell factor 4 (Gene ID: 6934, official gene symbol, TCF7L2) since they can share the same acronym. TCF4 and its paralogues, collectively known as E-proteins, interact with other bHLH proteins to regulate DNA binding specificity and transcriptional activity at promoters and enhancers that contain E-boxes (5′-CANNTG).2,20,23 The human TCF4 gene encodes multiple protein isoforms of which only the major isoforms TCF4-A and TCF4-B have been characterized in detail.24 In neurons, TCF4 regulates the intrinsic excitability of pyramidal cells of the prefrontal cortex and has been shown to attenuate neurite branching.25,26 Furthermore, haploinsufficiency of Tcf4 in mice affects gene expression and DNA methylation in the brain, leading to enhanced long-term potentiation, learning and memory deficits, and autistic-like behavior.22,25,26 By contrast, mice over-expressing Tcf4 in the brain display deficits in sensorimotor gating, fear conditioning, and circadian processes as well as impairments in attentional and behavioral anticipation.7,27

The Psychiatric Risk Gene Transcription Factor 4 (TCF4) Regulates Neurodevelopmental Pathways Associated With Schizophrenia, Autism, and Intellectual Disability

AbstractBackground. Common genetic variants in and around the gene encoding transcription factor 4 (TCF4) are associated with an increased risk of schizoph

academic.oup.com

 

[Intellau_Celistic]

I see.

View: https://youtu.be/XfR9iY5y94s?t=32

 

[Intellau_Celistic]

 

[IncelKing]

This describes me 100%

 

[Puppeter]

This describes me 100%

 

[Intellau_Celistic]

...

1000Genomes_30x	Global	Study-wide	4805	C=0.3209	G=0.6791
1000Genomes_30x	African	Sub	1328	C=0.2372	G=0.7628
1000Genomes_30x	Europe	Sub	961	C=0.359	G=0.641
1000Genomes_30x	South Asian	Sub	883	C=0.249	G=0.751
1000Genomes_30x	East Asian	Sub	878	C=0.397	G=0.603
1000Genomes_30x	American	Sub	755	C=0.415	G=0.585

 

[Intellau_Celistic]

View: https://vocaroo.com/1jRHhVxQGBbC

...