Cohersion is endemic in every relationship, doesn't matter it's nature nor origin. Spending time with foids can seen like a stressor now, due to the sexual dynamics and psycho-biological hierarchies that we naturally follow. However, humans are very adaptable, and so it is the treshold for our confort zone. Even if we got to exterminate all the female gender, a new and more opressively intricate socio-sexual order would arise to replace the old one.
The better course of action, taking in consideration your own nihilistic tendencies, is to gas every single human being, thus ending the torture that is being subjected to determinism, be it sexual, social, biological, cultural, genetic or whatever. Death should be qually distributed for us to build the perfect utopia. No more organic chaos, no more pain.