painedoverbitecel
Banned
-
- Joined
- Aug 15, 2023
- Posts
- 277
Always report everything. I've seen people say that doing that will make your employer look for an excuse to fire you. They're already doing that anyway. Don't be a slave to ntscum
Yeah obviously women hr people should not be spoken toI refuse to work with foids, communicate with foids, report to a foid higher up, cooperate with foids, share information with foids, or any other social interaction that would not be having sex.
Why are all HR women? Never seen a male oneYeah obviously women hr people should not be spoken to
For real man. I think it’s one of their power plays, like how they act with power that’s disproportionate to what they’ve earned.Why are all HR women? Never seen a male one
The Psychiatric Risk Gene Transcription Factor 4 (TCF4) Regulates Neurodevelopmental Pathways Associated With Schizophrenia, Autism, and Intellectual Disability
Genetic variants in and around the transcription factor 4 (TCF4) gene are associated with range of disorders that are frequently associated with cognitive dysfunction.1–3 The most recent schizophrenia GWAS reported three independent single nucleotide polymorphisms (SNPs) in TCF4 that surpassed the threshold for genome wide significance.4 Intriguingly, rare TCF4 single nucleotide variants (SNVs) have also been described in schizophrenia patients, although their impact on the function of the protein has not been established.5,6 In addition to the genetic studies in schizophrenia, TCF4 variants are associated with early information processing and cognitive markers, some of which are schizophrenia endophenotypes.7–10 Damaging TCF4 mutations have also been described in large-scale genotyping studies in patients with ID, neurodevelopmental disorders, and most recently ASD.11–15 Haploinsufficiency of TCF4 causes Pitt–Hopkins syndrome (PTHS); a rare form intellectual disability (ID) associated with characteristic facial features, autonomic dysfunction, and behavioral traits that resemble autism spectrum disorder (ASD).16–19 Collectively, these studies implicate TCF4 in a range of neurodevelopmental disorders.
CF4 is a member of the basic helix-loop-helix (bHLH) family of proteins.20–22 For the purposes of disambiguation, it should be noted that TCF4 (Gene ID: 6925) described herein should not be confused with T-cell factor 4 (Gene ID: 6934, official gene symbol, TCF7L2) since they can share the same acronym. TCF4 and its paralogues, collectively known as E-proteins, interact with other bHLH proteins to regulate DNA binding specificity and transcriptional activity at promoters and enhancers that contain E-boxes (5′-CANNTG).2,20,23 The human TCF4 gene encodes multiple protein isoforms of which only the major isoforms TCF4-A and TCF4-B have been characterized in detail.24 In neurons, TCF4 regulates the intrinsic excitability of pyramidal cells of the prefrontal cortex and has been shown to attenuate neurite branching.25,26 Furthermore, haploinsufficiency of Tcf4 in mice affects gene expression and DNA methylation in the brain, leading to enhanced long-term potentiation, learning and memory deficits, and autistic-like behavior.22,25,26 By contrast, mice over-expressing Tcf4 in the brain display deficits in sensorimotor gating, fear conditioning, and circadian processes as well as impairments in attentional and behavioral anticipation.7,27
It's bc they're non-threatening. At least to normies, due to lessened hostilityFor real man. I think it’s one of their power plays, like how they act with power that’s disproportionate to what they’ve earned.
Oh no, if on;y it wasn't all their fault. Oh wellI sadly have to work in a office full of stacys or get kicked out of the only place I can stay (my fathers house). They are all visibly disgusted by me since day 1. Often we have to work in teams. I work slow as fuck and waste their time as much as I can. Files get mysteriously damaged or deleted. Such a tragedy.![]()
It's a less demanding job, making it the perfect way for companies to meet the women employment ESG criteria without wasting too much money employing women on higher ranks.Why are all HR women? Never seen a male one
Why is ESG so important?It's a less demanding job, making it the perfect way for companies to meet the women employment ESG criteria without wasting too much money employing women on higher ranks.
*Obviously fefails shouldn't be allowed to speak or have any rights whatsoever.Yeah obviously women hr people should not be spoken to
Yeah absolutely true. They secretly hate having rights*Obviously fefails shouldn't be allowed to speak or have any rights whatsoever.
They have disdain for men that grant them power. It shows a mentally rooted weakness in said men, which femoids hate.Yeah absolutely true. They secretly hate having rights
Yes. I like to scare them in publicThey have disdain for men that grant them power. It shows a mentally rooted weakness in said men, which femoids hate.
fakecel alertI refuse to work with foids, communicate with foids, report to a foid higher up, cooperate with foids, share information with foids, or any other social interaction that would not involve having raw sex.
It's one of the measures that potential investors take into account when deciding in what company they will invest. The ideia is that the ESG score expresses how stable a company is.Why is ESG so important?





