
NotForMe1
Banned
-
- Joined
- Oct 22, 2019
- Posts
- 362
https://www.ncbi.nlm.nih.gov/m/pubmed/21982312/ (Sample : 2 416 men, Average age: 75.4, Mean TT: 454 ng/dl)
https://www.ncbi.nlm.nih.gov/m/pubmed/31019640/ (Sample : 382 men, Average age : 64, Mean TT: 567 ng/dl)
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2902069/ (Sample : 1445 men, Average age: 61, Mean TT: 583 ng/dl)
All of these studies were done on randomly selected healthy, non obese men. Two of the studies studied the releationship between testosterone levels and cardiovascular disease and both reached the same conclusion that testosterone levels below 550 ng/dl, even with adjusting for all other factors significantly increase the risk of CV disease.
Study 1:
"During a median 5-year follow-up, 485 CV events occurred. Both total testosterone and SHBG levels were inversely associated with the risk of CV events (trend over quartiles: p = 0.009 and p = 0.012, respectively). Men in the highest quartile of testosterone (≥550 ng/dl) had a lower risk of CV events compared with men in the 3 lower quartiles (hazard ratio: 0.70, 95% confidence interval: 0.56 to 0.88). This association remained after adjustment for traditional CV risk factors and was not materially changed in analyses excluding men with known CV disease at baseline (hazard ratio: 0.71, 95% confidence interval: 0.53 to 0.95). In models that included both testosterone and SHBG, testosterone but not SHBG predicted CV risk"
Study 2:
"The study results showed that T-T is independently and inversely associated with WBPT in male patients with traditional cardiovascular risk factor and no history of cardiovascular disease. In addition, this study suggests that the incidence of primary cardiovascular events can be prevented by maintaining T-T at approximately ≥ 550 ng/dL from the perspective of blood rheology."
TRT has also been proven to signifacantly decrease the risk of heart attack, stroke and all cause mortality in people with low T, further proving the cardioprotective effects of testosterone:
https://www.ncbi.nlm.nih.gov/m/pubmed/26248567/
The third study showed that people with TT in the bottom 2.5 procent of the population (below 350 ng/dl) are at a significantly higher risk of mobility limitiations.
So, the question is, what should we consider as low? In my opinion (and it's not gonna be a popular one here) anything below 550 ng/dl should be considered as low given than now 2 independent studies have shown that testosterone levels below 550 ng/dl significantly increase the risk of CV disease and CV disease is the leading cause of death worldwide.
Also according to the data 550 is below the average for a 64 yr old.
https://www.ncbi.nlm.nih.gov/m/pubmed/31019640/ (Sample : 382 men, Average age : 64, Mean TT: 567 ng/dl)
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2902069/ (Sample : 1445 men, Average age: 61, Mean TT: 583 ng/dl)
All of these studies were done on randomly selected healthy, non obese men. Two of the studies studied the releationship between testosterone levels and cardiovascular disease and both reached the same conclusion that testosterone levels below 550 ng/dl, even with adjusting for all other factors significantly increase the risk of CV disease.
Study 1:
"During a median 5-year follow-up, 485 CV events occurred. Both total testosterone and SHBG levels were inversely associated with the risk of CV events (trend over quartiles: p = 0.009 and p = 0.012, respectively). Men in the highest quartile of testosterone (≥550 ng/dl) had a lower risk of CV events compared with men in the 3 lower quartiles (hazard ratio: 0.70, 95% confidence interval: 0.56 to 0.88). This association remained after adjustment for traditional CV risk factors and was not materially changed in analyses excluding men with known CV disease at baseline (hazard ratio: 0.71, 95% confidence interval: 0.53 to 0.95). In models that included both testosterone and SHBG, testosterone but not SHBG predicted CV risk"
Study 2:
"The study results showed that T-T is independently and inversely associated with WBPT in male patients with traditional cardiovascular risk factor and no history of cardiovascular disease. In addition, this study suggests that the incidence of primary cardiovascular events can be prevented by maintaining T-T at approximately ≥ 550 ng/dL from the perspective of blood rheology."
TRT has also been proven to signifacantly decrease the risk of heart attack, stroke and all cause mortality in people with low T, further proving the cardioprotective effects of testosterone:
https://www.ncbi.nlm.nih.gov/m/pubmed/26248567/
The third study showed that people with TT in the bottom 2.5 procent of the population (below 350 ng/dl) are at a significantly higher risk of mobility limitiations.
So, the question is, what should we consider as low? In my opinion (and it's not gonna be a popular one here) anything below 550 ng/dl should be considered as low given than now 2 independent studies have shown that testosterone levels below 550 ng/dl significantly increase the risk of CV disease and CV disease is the leading cause of death worldwide.
Also according to the data 550 is below the average for a 64 yr old.