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The Shay Files: "Mental Illness"

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Complete social absence
 
I'm mute, but they should be available to chat.
 
Anyway...back to the past.
 
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"Alright. Let's go"

...


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Main Text​

Since the discovery of HIV-1 proteinase in the mid-1980s, this enzyme probably has become the best-characterized peptidase, with several hundreds of crystal structures of inhibitor complexes determined to date. However, the main proteinase of SARS coronavirus (Mpro, also called 3CLpro) has a good chance to catch up. When the first three-dimensional structure of a coronavirus Mpro was published in 2002, that of the enzyme from transmissible gastroenteritis virus (TGEV) [
2
], interest in the coronaviridae was only moderate, since these viruses were considered relatively harmless to human health. This assessment changed dramatically in late March, 2003, when it was found that the ongoing global outbreak of the highly infectious severe acute respiratory syndrome was caused by a new coronavirus, subsequently named SARS-CoV. Since then, efforts to discover anti-SARS drugs have been numerous, in order to be prepared should the virus raise its ugly head again.
Coronavirus genomes code for two large polyproteins, pp1a and pp1ab, that are processed by viral proteinases to yield the individual components of the large replicase complex. Most coronaviruses have three cysteine proteinases that are responsible for this processing: two papain-like proteinases and the main proteinase, Mpro. Interestingly, one of the two papain-like proteinases is absent in the SARS coronavirus, and the other one has been shown to have the additional function of a deubiquitinating enzyme [
3
,
4
]. While the papain-like proteinases together are only responsible for three cleavage reactions near the N terminus of the polyproteins, the Mpro cleaves these huge substrates (molecular masses of 450–750 kDa) at no less than 11 sites. Since this reaction is essential for viral replication, the main proteinase is obviously a prime target for interference by inhibitors [
5
].
As a first step toward inhibitor design for coronavirus Mpros, the crystal structure was elucidated for a complex between the TGEV enzyme and a hexapeptidyl chloromethyl ketone inhibitor that had an amino acid sequence corresponding to the specificity of the enzyme [
6
]. The mode of binding of this inhibitor to the target enzyme was found to be related (although not identical) to what had been seen earlier in a complex between the rhinovirus (HRV-2) 3C proteinase and compound AG7088 (Figure 1A), a vinylogous ethyl ester developed by Agouron Inc. (now a division of Pfizer) for the treatment of the common cold caused by rhinoviruses [
7
]. This observation led to the proposal that AG7088 should be a good starting point for the design of anti-SARS inhibitors [
6
].
Figure thumbnail gr1

Figure 1Chemical formulas of (A) AG7088, (B-D) AG7088 derivatives, (E) lopinavir, (F) 1-(benzoyloxy)-benzotriazole (R=4-NHCH3, 4-N(CH3)2, or 4-N(C2H5)2).
The crystal structures of the main proteinases of human coronavirus 229E and then of the SARS virus itself were solved within weeks after identification of the new virus [
]) are competitive inhibitors with Ki values in the lower micromolar range and are thus among the most potent noncovalent inhibitors of the SARS-CoV Mpro described to date. The discovery of compounds binding noncovalently to the Mpro may, in the end, constitute a more important milestone on the way to clinically useful inhibitors of the coronavirus main proteinase than identification of the acylating agents.
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Formulating an effective HIV vaccine remains a formidable challenge despite nearly 3 decades of intense research since the virus was first isolated. One of the obstacles that need to be surmounted is the design of a preparation that elicits a potent and broadly neutralizing antibody (nAb) response, i.e. antibodies with the capacity to block infectivity of the genetically diverse pool of HIV strains that circulate globally. The primary target for nAbs on HIV-1 is the envelope glycoprotein spike (Env). Early work on elucidating the exposure of antibody epitopes on Env suggested highly restricted accessibility of antibodies to epitopes that are conserved among otherwise diverse virus isolates. Crystal structures of Env-derived antigens, most in complex with antibodies, along with structure-function studies and molecular modeling, have provided significant further insight into features of Env that limit broad antibody recognition. Despite these challenges, recent progress on various fronts has led to a growing sense that Env is not as impenetrable to nAbs as might have been believed in the past. Increased understanding of antibody epitope exposure on Env should provide new impulses for efforts to elicit nAbs that can protect against HIV-1 infection.
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Measles is one of the most infectious diseases with a high mortality rate worldwide. It is caused by the measles virus (MeV) which is a single stranded RNA virus with genetic diversity based on the nucleoprotein gene, including 24 genotypes. In Gabon, several outbreaks occurred in the past few years, especially in 2016 in Libreville and Oyem. A surveillance network of infectious diseases highlighted a measles outbreak which occurred in the south of Gabon from April to June 2017.

Methods​

Clinical specimens of urine, blood, throat and nasal swabs were collected in the two main cities of the Haut-Ogooue province, Franceville and Moanda. Virological investigations based on real-time polymerase chain reaction for molecular diagnosis and conventional PCR for genotype identification were done.

Results​

Specimens were collected from 139 suspected measles patients. A total of 46 (33.1%) children and adults were laboratory-confirmed cases among which 16 (34.8%) were unvaccinated, 16 (34.8%) had received one dose, and 11 (23.9%) had received two doses of the measles vaccine. Phylogenetic analysis revealed that all the sequences of the nucleoprotein gene belonged to genotype B3.

Conclusions​

Measles infection was more commonly confirmed among those with one recorded dose compared to suspect cases with none, unknown or two recorded doses. The molecular characterization of the strains showed the circulation of the B3 genotype which is endemic on the African continent, thirty years after the B2 genotype was described in an outbreak in Libreville, the capital of Gabon. These findings highlight that surveillance and molecular investigation of measles should be continued in Gabon.https://bmcinfectdis.biomedcentral.com/articles/10.1186/s12879-019-3731-y
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age or comorbid conditions.https://pubmed.ncbi.nlm.nih.gov/23192911/
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Despite the mesocorticolimbic dopaminergic pathway being one of the main substrates underlying stimulating and reinforcing effects induced by psychostimulant drugs, there is little information regarding its role in their effects at the immune level. We have previously demonstrated that acute exposure to amphetamine (5 mg/kg, i.p.) induced an inhibitory effect on the splenic T-cell proliferative response, along with an increase in the methionine(met)-enkephalin content at limbic and immune levels, 4 days after drug administration. In this study, we investigated if a possible dopamine mechanism underlies these amphetamine-induced effects by administering D1 and D2 dopaminergic antagonists or a dopaminergic terminal neurotoxin before the drug. Pre-treatment with either SCH-23390 (0.1 mg/kg, i.p.) or raclopride (0.1 mg/kg, i.p.), a D1 or D2 dopaminergic receptor antagonist, respectively, abrogated the effects of amphetamine on the lymphoproliferative response and on met-enkephalin levels of the spleen. The amphetamine-induced increase in limbic met-enkephalin content was suppressed by SCH-23390 but not by raclopride pre-treatment. Finally, an intra-accumbens 6-hydroxy-dopamine injection administered 2 weeks previously prevented amphetamine-induced effects on the lymphoproliferative response and on met-enkephalin levels in the prefrontal cortex and spleen. These findings strongly suggest that D1 and D2 dopaminergic receptors are involved in amphetamine-induced effects at immune level as regards the lymphoproliferative response and the changes in spleen met-enkephalin content, whereas limbic met-enkephalin levels were modulated only by the D1 dopaminergic receptors. In addition, this study showed that a mesolimbic component modulated amphetamine-induced effects on the immune response, as previously shown at a behavioral level.

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Study of the function of epitopes of Mycobacterium tuberculosis antigens contributed significantly toward better understanding of the immunopathogenesis and to efforts for improving infection and disease control. Characterization of genetically permissively presented immunodominant epitopes has implications for the evolution of the host–parasite relationship, development of immunodiagnostic tests, and subunit prophylactic vaccines. Knowledge of the determinants of cross-sensitization, relevant to other pathogenic or environmental mycobacteria and to host constituents has advanced. Epitope-defined IFNγ assay kits became established for the specific detection of infection with tubercle bacilli both in humans and cattle. The CD4 T-cell epitope repertoire was found to be more narrow in patients with active disease than in latently infected subjects. However, differential diagnosis of active TB could not be made reliably merely on the basis of epitope recognition. The mechanisms by which HLA polymorphism can influence the development of multibacillary tuberculosis (TB) need further analysis of epitopes, recognized by Th2 helper cells for B-cell responses. Future vaccine development would benefit from better definition of protective epitopes and from improved construction and formulation of subunits with enhanced immunogenicity. Epitope-defined serology, due to its operational advantages is suitable for active case finding in selected high disease incidence populations, aiming for an early detection of infectious cases and hence for reducing the transmission of infection. The existing knowledge of HLA class I binding epitopes could be the basis for the construction of T-cell receptor-like ligands for immunotherapeutic application. Continued analysis of the functions of mycobacterial epitopes, recognized by T cells and antibodies, remains a fertile avenue in TB research.
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Rotavirus (RV) primarily infects enterocytes and results in severe diarrhea, particularly in children. It is known that the host immune responses determine the outcome of viral infections. Following infections, interferons (IFNs) are produced as the first and the main anti-viral cytokines to combat the virus. Here we showed that RV predominantly induced type III IFNs (IFN-λ1), and to a less extent, type I IFNs (IFN-α and IFN-β) in human intestinal cells. However, it did not produce detectable IFN proteins and thus, was not sufficient to inhibit RV replication. In contrast, we revealed the essential roles of the basal IFN signaling in limiting RV replication by silencing STAT1, STAT2 and IRF9 genes. In addition, exogenous IFN treatment demonstrated that RV replication was able to be inhibited by all types of IFNs, both in human intestinal Caco2 cell line and in primary intestinal organoids. In these models, IFNs significantly upregulated a panel of well-known anti-viral IFN-stimulated genes (ISGs). Importantly, inhibition of the JAK-STAT cascade abrogated ISG induction and the anti-RV effects of IFNs. Thus, our study shall contribute to better understanding of the complex RV-host interactions and provide rationale for therapeutic development of IFN-based treatment against RV infection.https://www.nature.com/articles/s41598-018-26784-9
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The aging brain is characterized by altered dopamine signaling. The amino acid tyrosine, a catecholamine precursor, is known to improve cognitive performance in young adults, especially during high environmental demands. Tyrosine administration might also affect catecholamine transmission in the aging brain, thereby improving cognitive functioning. In healthy older adults, impairments have been demonstrated in two forms of response inhibition: reactive inhibition (outright stopping) and proactive inhibition (anticipatory response slowing) under high information load. However, no study has directly compared the effects of a catecholamine precursor on reactive and load-dependent proactive inhibition. In this study we explored the effects of tyrosine on reactive and proactive response inhibition and signal in dopaminergically innervated fronto-striatal regions. Depending on age, tyrosine might lead to beneficial or detrimental neurocognitive effects. We aimed to address these hypotheses in 24 healthy older human adults (aged 61–72 years) using fMRI in a double blind, counterbalanced, placebo-controlled, within-subject design. Across the group, tyrosine did not alter reactive or proactive inhibition behaviorally but did increase fronto-parietal proactive inhibition-related activation. When taking age into account, tyrosine affected proactive inhibition both behaviorally and neurally. Specifically, increasing age was associated with a greater detrimental effect of tyrosine compared with placebo on proactive slowing. Moreover, with increasing age, tyrosine decreased fronto-striatal and parietal proactive signal, which correlated positively with tyrosine’s effects on proactive slowing. Concluding, tyrosine negatively affected proactive response slowing and associated fronto-striatal activation in an age-dependent manner, highlighting the importance of catecholamines, perhaps particularly dopamine, for proactive response inhibition in older adults.https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6084775/
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Re: ugh i got the cold
AnonyAnonymous
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#151809462Tuesday, December 16, 2014 12:22 PM CST
Ah, It's not a problem.Multiple types of antibiotics can be utilized against streptococcal bacteria such as "Fluoroquinolones".
Re: ugh i got the cold
AnonyAnonymous
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#151809542Tuesday, December 16, 2014 12:24 PM CST
'Multiple types of antibiotics can be utilized against streptococcal bacteria such as "Fluoroquinolones".'Well, assuming it's not a resistant strain.
Re: :Giveflu All
AnonyAnonymous
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#151809578Tuesday, December 16, 2014 12:25 PM CST
You may benefit from Oseltamivir.
Re: I hate PartehPoison
AnonyAnonymous
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#151809637Tuesday, December 16, 2014 12:27 PM CST
If you dislike the user, why not just simply stop reading content related to their behavior? It's evidently the cause of your anger.If the user is posting "Inappropriate-Content", allow the moderators to handle the situation by reporting the perpetrator.
Re: I hate PartehPoison
AnonyAnonymous
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#151809800Tuesday, December 16, 2014 12:32 PM CST
"@anonso does this mean i can report you for posting extremely irritating content"In theory, you can report a user for essentially anything you desire.Each decision has consequences though.
Re: ot whats your favorite pokemon design
AnonyAnonymous
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#151810110Tuesday, December 16, 2014 12:43 PM CST
"Kecleon", preferably.
Re: you guys are love experts give me advice
AnonyAnonymous
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#151810935Tuesday, December 16, 2014 1:09 PM CST
I'd suggest focusing on "Academic" priorities.You're likely suffering from psychological response to the hormonal changes caused by the presence of the opposite gender.
Re: When you cant eat pork and they put bacon in your burger
AnonyAnonymous
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#151810993Tuesday, December 16, 2014 1:11 PM CST
Why not just take it off the sandwich? There's still going to be grease however it'll be rather minimal.
Re: giving opinions 4 free
AnonyAnonymous
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#151811230Tuesday, December 16, 2014 1:18 PM CST
Alright then.Elaborate on your opinion regarding current Anti-Retroviral-Therapy for the treatment of "Human-Immunodefiency-Virus" infection.
Re: you guys are love experts give me advice
AnonyAnonymous
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#151811284Tuesday, December 16, 2014 1:20 PM CST
"Lmao shut up anonyYou say it like it's not human nature"I never stated it was "Abnormal", It's quite common for individuals to experience chemical changes throughout the endocrine system in the presence of the opposite gender.I am stating, however, that there's plenty of other crucial priorities that should be taken into consideration.
Re: it feels like something is going to pop out of my chest
AnonyAnonymous
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#151816267Tuesday, December 16, 2014 3:12 PM CST
It could be extensive pressure on your cardiovascular system, I'd suggest seeking medical examination.
Re: Honesty Paradox.
AnonyAnonymous
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#151822217Tuesday, December 16, 2014 4:40 PM CST
The person's opinion on the subject may not be entirely negative, It's entirely possible for an individual to genuinely adapt their thinking to fit the circumstances.Additionally, what the individual may consider "Kind" can actually be considered "Unkind" by the opposing side thus this isn't necessarily a "Paradox".
Re: You're sitting on the computer so selfishly
AnonyAnonymous
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#151822363Tuesday, December 16, 2014 4:42 PM CST
The statement itself is pure hypocrisy.Utilizing a Computer while the individuals on another continent suffer isn't necessarily "Selfish" as in the majority of cases, civilians are indirectly and unknowingly assisting other humans.
Re: WTF is hivemind?
AnonyAnonymous
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#151822488Tuesday, December 16, 2014 4:44 PM CST
Although it's somewhat different, I'd suggest analyzing "Crowd-Psychology".
Re: So I realized why I'm not on any sort of OT lists
AnonyAnonymous
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#151824021Tuesday, December 16, 2014 5:02 PM CST
Every individual has their own personal pattern of linguistical convention and opinion regarding subjects, It's simply just a matter of skepticism towards other variations.Having your username on an insignificant virtual list is inessential, enjoyment while utilizing the website and making your own determinations regarding the content itself is the crucial aspect.
Re: anyone know how i can get past roblox censor?
AnonyAnonymous
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#151824573Tuesday, December 16, 2014 5:09 PM CST
If the words you're attempting to post are being censored, It's a firm indicator that you should reconsider the actual intention behind the words being utilized.
Re: whats point staying on OT hoping, some how, it'll get better
AnonyAnonymous
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#151824833Tuesday, December 16, 2014 5:12 PM CST
The positivity of the Sub-Section depends entirely on the perception and behavior of every individual involved.There's always going to be some degree of negativity because of variation in opinion.
Re: anyone know how i can get past roblox censor?
AnonyAnonymous
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#151824936Tuesday, December 16, 2014 5:13 PM CST
"it no work"That's good then, "Filter-Bypassing" violates numerous rules in the "Roblox Community Guidelines".
Re: me > you
AnonyAnonymous
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#151825272Tuesday, December 16, 2014 5:18 PM CST
Condescending over an internet forum is purely unnecessary and indicates a significant degree of insecurity.
Re: thatMaggyGirl is the greatest person to walk on the earth
AnonyAnonymous
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#151826078Tuesday, December 16, 2014 5:29 PM CST
"Who is she anyways? :\"Simply another user that occasionally creates threads centered around boasting about their accomplishments and "Superior-Aspects".It's certainly not something to become enraged to the extremity of insulting the user though.
Re: who the heck are you
AnonyAnonymous
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#151850616Tuesday, December 16, 2014 10:46 PM CST
In all actuality, every user here can be considered as "Hiding behind a screen".
Re: who the heck are you
AnonyAnonymous
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#151851058Tuesday, December 16, 2014 10:54 PM CST
"you didn't take care of yourself enough not to be filled with bacteries"Every human has billions of bacteria inside and outside of their body, cleanliness only slightly reduces the quantity.Most of the bacteria themselves are highly beneficial.
Re: [ Content Deleted ]
AnonyAnonymous
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#151852860Tuesday, December 16, 2014 11:40 PM CST
The Internet or nearly anything in general, actually, does not truly have a "Best" individual, rather, a user's perception of themselves and other individuals relies entirely on subjective interpretation of characteristics they choose to analyze.
Re: [ Content Deleted ]
AnonyAnonymous
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#151853511Wednesday, December 17, 2014 12:01 AM CST
"at least i get hall of fame"The "Hall-Of-Fame" is merely a medium with the intention of conveying the individuals who subjectively had a significant quantity of influence on the individual inducting the person.Do not base your overall worth on the opinion of users from an Internet forum, It's not truly indicative of your capabilities.
Re: wow im getting..a lot of anon hate on tumblr..
AnonyAnonymous
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#151854165Wednesday, December 17, 2014 12:26 AM CST
The opinion of an individual over an "Anonymous" interface cannot be blamed solely on the 'perpetrator', It is the decision of each individual to like or dislike another person via analysis of the other person's supposed characteristics.Do not become saddened at the consistent array of insults you may receive, those individuals cannot truly determine your self-worth outside of a screen, make viable and firm decisions as you cannot completely convince every individual to adapt your perception ...
 
Re: I wonder if I can manipulate the new OT'ers
AnonyAnonymous
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#151786569Monday, December 15, 2014 8:59 PM CST
Why do you desire to manipulate the users new to the Sub-Section, such as myself?
Re: I wonder if I can manipulate the new OT'ers
AnonyAnonymous
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#151788919Monday, December 15, 2014 9:25 PM CST
"@AnonyI don't consider you a new person"Ah, we are all inexperienced in some aspects.
Re: Remember Fireburn1x?
AnonyAnonymous
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#151789093Monday, December 15, 2014 9:28 PM CST
There was never any actual "Battle", It's simply just occasional occurrences that result in "Interesting" discussions.
Re: Remember Fireburn1x?
AnonyAnonymous
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#151789435Monday, December 15, 2014 9:33 PM CST
"However those "interesting" discussions reciprocate into multiple fonts of "knowledge battles" so here we are again, doing such in a paradoxical situation"I wouldn't consider those "Knowledge Battles" as actual battles.Rather, I'd consider them a simple, positive exchange of opinion and perception.
Re: Legit Hacker Tools
AnonyAnonymous
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#151791714Monday, December 15, 2014 10:09 PM CST
Discussion of "Hacking Software" is strictly prohibited within the "Roblox Community Guidelines".Also, there's plenty of algorithms to create your own tools.
Re: Legit Hacker Tools
AnonyAnonymous
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#151791870Monday, December 15, 2014 10:12 PM CST
"We're not all smart like you."Enthusiasm, suitable circumstances and motivation provides the necessary framework to improvise a solution to the common problems encountered.The complexity of creating software for the purpose of breaching security depends on which aspect you're targeting and the algorithmic/mathematical aspects being incorporated in conjunction with conceptual ideas.
Re: Legit Hacker Tools
AnonyAnonymous
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#151791936Monday, December 15, 2014 10:13 PM CST
"Algorithms are structured formulas to create solutions, anon."Exactly.There's a wide array of algorithms that you can utilize to develop solutions to common security mechanisms.
Re: Help me find what hat is this
AnonyAnonymous
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#151792444Monday, December 15, 2014 10:22 PM CST
That's actually a legitimate "Roblox" link.
Re: Legit Hacker Tools
AnonyAnonymous
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#151792647Monday, December 15, 2014 10:26 PM CST
"@AnonyAnything you don't know?"Ah, there's plenty of things that either of the users posting in this thread lack knowledge of.
Re: Why do we measure respect in post amount?
AnonyAnonymous
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#151792999Monday, December 15, 2014 10:32 PM CST
It's unreasonable to generalize every user as having the "Mentality" described in the topic description.Although, "Quality" is much more important than "Quantity" in this scenario.
Re: Bring back Safechat idea.
AnonyAnonymous
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#151793492Monday, December 15, 2014 10:43 PM CST
This would be much more preferable in the "Suggestions & Ideas" Sub-Section.Although, I'd personally prefer a system that allows users to communicate more proficiently with Guests.
Re: i'm sick of life right now
AnonyAnonymous
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#151793926Monday, December 15, 2014 10:54 PM CST
I'd suggest that you try taking the initiative to communicate with someone you consider credible enough to assist you in the situation.A professional "Psychologist" may be able to assist you through this process.
Re: i'm sick of life right now
AnonyAnonymous
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#151794164Monday, December 15, 2014 11:00 PM CST
"I'd suggest that you try taking the initiative to communicate with someone you consider credible enough to assist you in the situation.A professional "Psychologist" may be able to assist you through this process."Expanding off of this statement further, you may benefit significantly from attempting to develop a proficient system of communication with the individual currently attempting to provide a platform of support for your current problems.Insults about your "Weight" is entirely irrelevant to the lives of the individuals insulting you and the fact they intend to do this indicates a significant level of self-perceived inferiority.Over-all, however, you'll need to communicate with other individuals in addition to assisting yourself to improve the situation.
Re: i'm sick of life right now
AnonyAnonymous
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#151794365Monday, December 15, 2014 11:05 PM CST
"@anonyyeah, i guess you're rightshouldn't really look at myself that way"It's very common for individuals to receive consistent insults that result in the development of a negative perception of themselves, and this can be quite difficult to recover from significantly.Yet, it requires a system of consistent management of your overall problems and often individuals never fully recover, though they may benefit significantly.
Re: i'm sick of life right now
AnonyAnonymous
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#151794640Monday, December 15, 2014 11:12 PM CST
"Giving people the advice that they should develop a positive attitude of themselves assumes there is objective inherent value in a positive attitude of which there is no reason to believe so."I never directly stated that the topic creator should develop a completely positive perception of themselves.The actual purpose of the suggestions I stated is to provide advice regarding strategies that the topic creator could potentially utilize to decide whether they want to change their own person...
Re: list of free stuff i get
AnonyAnonymous
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#151794754Monday, December 15, 2014 11:15 PM CST
Are you referring to "Native-Americans"?
Re: might consider making a tulpa again
AnonyAnonymous
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#151795819Monday, December 15, 2014 11:52 PM CST
I wouldn't suggest attempting to create abstract beings for the purpose of psychological manipulation.This can easily result in severe and psychologically destructive effects.
Re: might consider making a tulpa again
AnonyAnonymous
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#151795981Monday, December 15, 2014 11:59 PM CST
"@anonyI'm in near complete social isolationI'm getting dug into a holeIt may be extremely hard to get pulled out of the holeBut the tulpa is supposed to help stop the diggingMake me feel wanted by someone that isn't online, you know?"Abstraction is simply not the answer to your problems.You're attempting to use abstraction as a means of making yourself oblivious to the problems you're having, yet it's only going to cause further issues.Attempting to communicate with abstract beings...
Re: i think ive messed up big time OT
AnonyAnonymous
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#151807878Tuesday, December 16, 2014 11:29 AM CST
If you're in a potentially dangerous situation, I'd suggest contacting a qualified authority figure to assist you in the situation.Attacking the person will only cause more issues.
Re: Vircivitali = crappy oter
AnonyAnonymous
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#151807983Tuesday, December 16, 2014 11:32 AM CST
"He minimodded goldensight."If 'goldensight' decided to violate the "Roblox Community Guidelines", then it's his fault for getting banned."Vicivitali" shouldn't receive aggressive insults simply because of a vendetta against him.
Re: anyone up for a lil troll
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#151808053Tuesday, December 16, 2014 11:35 AM CST
They did absolutely nothing to bother you as a whole, simply report them.
Re: Guys I'm home alone...
AnonyAnonymous
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#151808317Tuesday, December 16, 2014 11:46 AM CST
"this comp. is watched by the F.B.I."I can assure that plenty of sources are monitoring your overall computational usage.
Re: Guys I'm home alone...
AnonyAnonymous
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#151808358Tuesday, December 16, 2014 11:48 AM CST
I'd suggest that you research "Academical" information.
 
Re: Guys I'm home alone...
AnonyAnonymous
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#151808358Tuesday, December 16, 2014 11:48 AM CST
I'd suggest that you research "Academical" information.
Re: ugh i got the cold
AnonyAnonymous
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#151808388Tuesday, December 16, 2014 11:49 AM CST
Which pathogen caused your infection?
Re: ugh i got the cold
AnonyAnonymous
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#151809305Tuesday, December 16, 2014 12:17 PM CST
"I have strep throat"Are you utilizing a Penicillin-based antibiotic for your streptococcal infection?
 
1715166734092

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#182597970Thursday, January 28, 2016 10:21 PM CST
A conditional statement would allow you to accomplish this.Presumably, you could create an algorithm such as this:function Check_Gold()Gold = 1;Maximum_Number = 10;if(Gold < Maximum_Num)thenGold = Gold + 1; Increases the value if the variable "Gold" is lesser than the limit;elseprint("You have reached the gold limitation!");Event:connect(Check_Gold);
Re: noob help
ParadigmaticAnon
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#182598438Thursday, January 28, 2016 10:28 PM CST
"Hop off my block anon"Yes, it appears that I did not recognize the explicit flaw of defining the variables within the scope of the function.Oh well, I suppose that you can handle the onward explanation.
C Discussion Thread
ParadigmaticAnon
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#182598989Thursday, January 28, 2016 10:38 PM CST
Hello. The purpose of this thread is to discuss the use of C-based programming to manipulate data supplied to computing-system.Due to an obvious technicality involving scripting/programming, this would not be "appropriate" for the Scripters sub-section. As a result, any such suggestions will be ignored entirely.References to custom libraries are permitted.
Re: Somebody please explain elunates wrapper.
ParadigmaticAnon
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#182599224Thursday, January 28, 2016 10:42 PM CST
Why, it is a matter of programming-paradigms. Pure abstraction.Analyze the individual conceptual components of the script. Afterwards, synthesizing them together will be much easier.
Re: Where can I learn HTML?
ParadigmaticAnon
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#182599336Thursday, January 28, 2016 10:44 PM CST
Ah, here you go:http://www.tutorialspoint.com/html/index.htm
Re: C Discussion Thread
ParadigmaticAnon
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#182599997Thursday, January 28, 2016 10:58 PM CST
"I use code::blocks, what would you suggest?"I generally prefer to utilize a MingGW terminal, for file organization purposes.As for your project, it seems rather interesting. How exactly does your AI program generate new combinations when accurate answers are found, within the array?
Re: HELP!
ParadigmaticAnon
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#183484075Friday, February 12, 2016 10:47 PM CST
"I was just looking for 2 hours and all I learned was how printing works"Perhaps you should consider using a more "fluid" approach to the issue, then.Scripting is merely a utility to manipulate a computer to solve self-identified problems. It is not a process of pure memorization.Nonetheless, it is necessary to understand the available functionality and operations within your given language so that you can utilize them to efficiently solve the designated problem.Consider performing research on "Algorithmic problem-solving." It may suit your desires quite well.
Re: Scripting
ParadigmaticAnon
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#183484506Friday, February 12, 2016 10:56 PM CST
The "FindFirstChild()" method will return the actual object if found, rather than the Boolean value true. As a result, your comparison will not actually function as theorized.Since non-nil data will be returned, "if(FindFirstChild(Obj.Name))then" will give you desired result, given that all "non-false" data will be evaluated as "true" within the conditional statement, which will result in the expression's execution.
Re: Binary Sequences Discussion Thread
ParadigmaticAnon
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#183484734Friday, February 12, 2016 11:01 PM CST
Well then, I suppose that a computational example will garner interest.Computers utilize binary sequences to store data. Each bit represents a specific instruction to be manipulated by components of the CPU.This is accomplished by utilizing "0" and "1" to represent separate voltage states of a given segment of the hardware. "0" refers to low-voltage, and "1" refers to high-voltage.Thus, imagine a sequence such as "01010101" as merely representing the computer sequentially reversing the voltage states of various signals within hardware gates. Each gate represents the basic logical operations of AND, OR, NOT, XOR.Perhaps this will interest fellow users?
Re: HELP!
ParadigmaticAnon
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#183485382Friday, February 12, 2016 11:13 PM CST
"expect to know how to make stuff within 2 weeks. I know this may be asking for a lot but could somebody possibly type out most scripting terms with there definitions summarized?"Mezur, while I believe I can understand your sudden enthusiasm for creating content, it is necessary to understand that theory precedes application.It is not just a matter of understanding "how" to give the computer specific instructions; it is a matter of understanding "why" your instructions can be devised in a certain way to accurately solve problems you identify.I would personally state that it is very questionable/abysmal to quickly utilize a given algorithm without understanding why it was constructed in a certain way.If you apply the necessary effort to understand the actual functionality of the mechanisms that compose the algorithm, you will be able to devise your own algorithms with ease.We cannot provide you with a simple summary of all the concepts involved. You will need to research them yourself.
Re: What is the "and" scripting term?
ParadigmaticAnon
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#183489119Saturday, February 13, 2016 12:45 AM CST
Ah, a community-based question-answering scheme. Splendid.The "and" keyword is merely a logical term within Lua that manipulates Boolean data values.We can utilize the logical AND/and operator to determine whether certain logical criteria has been fulfilled.An example would be the following:x = 1 and 2; --This would return the value of the second operand, 2.x = 2 and 1 --This would return the value of the second operand, 1.bool = true and false; --This would return false.bool = false and true --This would also return false.If the operands supplied to "and" are mixed Boolean values, the returned value of the operation will be false. If the values are both true simultaneously, the returned value will be the secondary value of the logical "and" operation.
Re: HELP!
ParadigmaticAnon
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#183489179Saturday, February 13, 2016 12:48 AM CST
"So I should just go on wiki and test stuff and try to learn random things in studio?"Certainly. Well, not necessarily "random" subjects. You should learn the concepts that you would like to use by experimenting with them thoroughly.
Re: how to use not operator?
ParadigmaticAnon
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#183489288Saturday, February 13, 2016 12:53 AM CST
Yes. The "not" operator merely retrieves the inverse of a supplied Boolean value.As an example, "not true" would return "false." Likewise, "not false" would return true.The "not" Boolean inverse of non-nil data is false. The Boolean inverse of nil itself is true.
Re: how to use not operator?
ParadigmaticAnon
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#183489390Saturday, February 13, 2016 12:57 AM CST
"would that print hello?"Given that the Boolean inverse of nil is "true", the value of your object would need to be true itself in order for the Lua expression to execute.
Re: Binary Sequences Discussion Thread
ParadigmaticAnon
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#183519765Saturday, February 13, 2016 12:37 PM CST
I have developed another explanation for the users on the sub-section.Suppose that we a machine containing six buttons. Each button can be successively activated/deactivated using a sequence of instructions. Each "button press" will reverse the button's current state. We can express this as a binary sequence of six bits.This will be our representation:000111In the above sequence for our machine, the first three buttons are deactivated. The last remaining three buttons are active.Natura...
Re: Help? For A Model Name
ParadigmaticAnon
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#183523216Saturday, February 13, 2016 1:24 PM CST
Yes. I would suggest giving your model a name that corresponds with the subject you intend to base it upon.For example, if you are making a castle/facility model orientated around Autumn/Halloween, a name such as "Pumpkin Palace" or "Leafy Cathedral" would suffice.
Re: Opinions on organization thread.
ParadigmaticAnon
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#183525684Saturday, February 13, 2016 1:56 PM CST
Perhaps a mixture of both would be preferable.A single, "main" subroutine can signal many discrete subroutines to perform separate tasks. The central subroutine can then proceed to organize/use the results of those completed tasks.
Greetings LMaDamaticians
ParadigmaticAnon
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#183529919Saturday, February 13, 2016 2:51 PM CST
Yes, hello there.I have arrived here to discuss the current trading ratios with the amateur trading mathematicians/regular users of LMaD.
Re: Greetings LMaDamaticians
ParadigmaticAnon
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#183530062Saturday, February 13, 2016 2:53 PM CST
Well, which formula are you using to optimize the potential value of your item exchanges?
Re: 9999 oters jumping on the bed
ParadigmaticAnon
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#183531394Saturday, February 13, 2016 3:10 PM CST
I presume this is an iterative game, yes?Well, it could be improved by consistently removing a random user within the range of 0 - 9999. This would also make it possible for a cycle to occur without any users being removed.Perhaps a variable such as the force exerted during each "jump" in a given cycle could be considered.
Re: Can't make a living being on Roblox all day
ParadigmaticAnon
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#183531677Saturday, February 13, 2016 3:15 PM CST
Yes, this is true.You cannot "make an actual living" solely by leeching resources from the game on a daily basis.However, you could potentially earn currency through the use of DevEx program available.
Re: syria's going to be invaded by saudi arabia
ParadigmaticAnon
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#183532174Saturday, February 13, 2016 3:22 PM CST
Yes. This is due to a much greater systematic plot by the "Western Alliance" to gain access to crude oil.I-SIL is merely a "puppet" thread designated to give those seeking control a "valid" reason to invade the territory.
Re: Anyone else here white but identify as asian?
ParadigmaticAnon
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#183536415Saturday, February 13, 2016 4:23 PM CST
Yes, plenty of individuals do.It is entirely comparable to an individual who suffers from Gender Dysphoria.
Re: I wish I was hispanic or black
ParadigmaticAnon
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#183536667Saturday, February 13, 2016 4:27 PM CST
You have a very horrid desire.Only an individual with severe psychological-illness would desire to become African American.
Re: There is a shape with 1,000,000 sides
ParadigmaticAnon
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#183536787Saturday, February 13, 2016 4:29 PM CST
Within the realm of geometrical abstraction, a shape can have as many sides as you desire.
Re: Binary Sequences Discussion Thread
ParadigmaticAnon
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#183540792Saturday, February 13, 2016 5:25 PM CST
"i thought u just kept dividing the number by two to put it into binary lolu make it seem complicated"Remember, we are not attempting to focus solely on methodologies. Rather, we are exploring the actual values that binary numbers represent. The process is much more rewarding when you can use a given skill to model logical solutions to seemingly difficult problems with computers.BurnOfFlames provided an excellent technique for converting between bases. It would make a very nice iterative a...
Re: How to print text on one line
AgnosticAnon
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#181470073Sunday, January 10, 2016 8:49 PM CST
Nemraz is correct.What I suppose is occurring is that the interpreter is comprehending the line as ending via the "\0" escape character, which is the null zero(Also known informally as the "string terminator") in C.Given that this would seem to prevent the use of escape sequences, you will need to concatenate each value onto a variable, as shown below:local s = ""; --I used an empty variable so that "Hello" will stack individual. The semicolons are a habit.while wait() do --Infinite loop. Self Explanatory.s = s.."hello";print(s);endHopefully that helped you.
Re: How to print text on one line
AgnosticAnon
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#181470554Sunday, January 10, 2016 8:56 PM CST
"answered : io.write"The standard I/O library is disabled inside ROBLOX.
Re: i just got rejected :( what do i say to her
AgnosticAnon
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#181470689Sunday, January 10, 2016 8:58 PM CST
'"If you ever feel like it I will always be here for you."'Why would you encourage the thread-creator to psychologically-enslave himself for a female narcissist?Erase the number and acquire mathematical/philosophical knowledge.Issue solved.
Re: how to go back to using windows 7/8.1
AgnosticAnon
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#181471051Sunday, January 10, 2016 9:03 PM CST
It is much simpler to save your data(Which should have been performed regardless), format your HDD, and simply reinstall Windows.This will also ensure that "leftovers" do not remain.
Re: How to print text on one line
AgnosticAnon
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#181471163Sunday, January 10, 2016 9:05 PM CST
"Scripting Helpers"Game-Design now. Scripting-Helpers was dissolved.Although most users deliberately post their questions inside Scripters.
Re: If I get term'd
AgnosticAnon
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#181471278Sunday, January 10, 2016 9:06 PM CST
You can easily create a new account.If you encounter any obstruction, simply use a new email/a proxy server.
Re: do you ever have those people you wish you made a move on
AgnosticAnon
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#181471599Sunday, January 10, 2016 9:11 PM CST
Define "made a move on."
Re: Typical white girls
AgnosticAnon
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#181471876Sunday, January 10, 2016 9:15 PM CST
Discrimination towards Caucasian women?Generally, they are much healthier on a physical and psychological-basis than "Yin" individuals.
Re: If I get term'd
AgnosticAnon
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#181472272Sunday, January 10, 2016 9:21 PM CST
"I would care you are a wonderful person and do not deserve that"If this is a hypothetical scenario(Evidently), how would you know what this user did to receive account-termination? And if you do not know what this user did to receive account-termination, how can you validly claim that they "did not deserve that"?
Re: lets make fake error messages
AgnosticAnon
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#181473245Sunday, January 10, 2016 9:37 PM CST
error("Warning! System Malfunctioning!");
Re: any other uk people online
AgnosticAnon
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#181473370Sunday, January 10, 2016 9:39 PM CST
Do you consider a Gaelic individual living in Brazil as a special exception?
Re: i still think about my first crush from the 8th grade
AgnosticAnon
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#181473567Sunday, January 10, 2016 9:42 PM CST
Yes it is.When I was a fourteen year-old individual, I regularly fantasized about a beautiful, intelligent Caucasian adolescent girl with brown-hair and blue-eyes that I saw at a grocery-store.It has been six years now, and I continue to have daily fantasies about this beautiful woman.
Re: i still think about my first crush from the 8th grade
AgnosticAnon
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#181474512Sunday, January 10, 2016 9:56 PM CST
"We both have partners, but I'm pretty confident that there is still a slight back-and-forth connection we have"You should take photos of the adolescent schoolchild covertly, as I previously did.It is very satisfying to convey your thoughts and energy towards receiving psychological-pleasure from female individuals.Now that I have located the object of my admiration after so many years, I am considering investing in a miniature camera, so that I can also have live recordings.
Re: The internet in 2 0 0 5
AgnosticAnon
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#181475471Sunday, January 10, 2016 10:13 PM CST
Being born in 2005 does not equate to having knowledge of the events of 2005.
Re: Why. Must people. Butcher. The English. Language.
AgnosticAnon
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#181477496Sunday, January 10, 2016 10:47 PM CST
I often experience such agitation upon seeing contraction words.
Re: what are some good songs for when youre in the feels
AgnosticAnon
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#181479208Sunday, January 10, 2016 11:15 PM CST
What do you mean by "in the feels"?
Re: Use 3 Words to describe yourself
AgnosticAnon
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#181479341Sunday, January 10, 2016 11:17 PM CST
Hedonistic Narcissistic Scum.
 
1715166935045

1715167063787

1715166920642


Subjective_Anon
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#190376672Friday, June 03, 2016 3:21 PM CDT
Okay. We will not discuss "controversial stuff," we will discuss objective evidence.Scientific evidence has shown that Negroid individuals are intellectually-inferior to Caucasoid individuals. Africa is a continent of primitive and inferior beings residing in huts while Europe is a utopia of technological advancement."Multiculturalism" is decimating America.
more_horiz
Re: what if trashposts weren't allowed on all fourms
Subjective_Anon
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#190376866Friday, June 03, 2016 3:24 PM CDT
You must have never been taught the definition of the word "subjective."



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Re: POST A SONG AND ILL RATE YOUR MUSIC TATE
UnsourcedAnon
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#184964008Monday, March 07, 2016 8:25 PM CST
"they suck so im not going to listen""they suck"? Such a naive and idiotic statement is very concerning.Culture Club is essentially superior to any of the aforementioned groups.Only your own idiocy prevents you from indulging in such domineering musical bliss.
Re: Watch me get my account deleted!
UnsourcedAnon
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#184964484Monday, March 07, 2016 8:31 PM CST
Ah, that is only the beginning.Account deletion is a sort of game.The more terminations obtained, the greater the tally-marks earned.It is respected immensely on the ROBLOX forum.
Re: Can OT count to 5?
UnsourcedAnon
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#184964977Monday, March 07, 2016 8:38 PM CST
5∑(1)1Ah, there you go.
Re: Can OT do the Alphabet Together?
UnsourcedAnon
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#184965271Monday, March 07, 2016 8:42 PM CST
Which alphabet exactly?
Re: first one to guess the number im thinking of..
UnsourcedAnon
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#184965459Monday, March 07, 2016 8:45 PM CST
Five is the answer, as five is quite literally the mid integer of one and ten.
Re: [ Content Deleted ]
UnsourcedAnon
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#184965651Monday, March 07, 2016 8:48 PM CST
Unfortunately, the NSA is monitoring statement of this type.I am hoping that you live outside the organization's jurisdiction.
1715167094657

Why Do So Many Imbeciles Detest Ethnic-Cleansing?
UnsourcedAnon
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#184811171Saturday, March 05, 2016 2:33 PM CST
Yes, why do so many imbeciles happen to detest ethnic-cleansing?The presence of opposing, idiotic beliefs pollutes and degrades the very structure of unity abundant throughout society.Two differing culture systems(Example being the European/Arabian migration crisis) cannot simply "cohabit" territory if their mediums for stability are in direct, uncertain conflict.Ethnic cleansing ensures that only the superior, logically-adept group survives. The pitiful, inferior cultural remnants are easily obliterated.Do you truly believe that Syrians are arriving within our patriotic country to "adapt"? If so, you are quite naive. The growing presence of Islam demonstrates this quite well.Truly, the leftists are not being "sympathetic" towards foreign individuals. They are merely attempting to desensitize us against the negative aspects of their culture(s).
Re: Where did Latin American come from?
UnsourcedAnon
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#184813661Saturday, March 05, 2016 3:09 PM CST
Simple. They have been tainted with inferior "Amerindian" DNA. It is quite comparable to mulatto hybrids.Various parasitic groups also have remnants of Polynesian DNA. It is quite repulsive.
Philosophy ∈ Mathematics
UnsourcedAnon
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#184814822Saturday, March 05, 2016 3:26 PM CST
Yes, it is quite true. Philosophy is enslaved by mathematics.Only imbeciles would deny such a fundamental detail.The concepts described in the first category are conveyed by the characteristics of the second category. Hence, the first is based on the logical-criteria of the second.Philosophers cry incessantly as they ponder their mathematical inferiority.
Re: Philosophy ∈ Mathematics
UnsourcedAnon
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#184815128Saturday, March 05, 2016 3:30 PM CST
"op cries incessantly at his lack of gf"Ah, you are making plenty of assumptions, Heartstrings.Such assumptions are entirely idiotic. You must be quite upset that I recognize and publicly convey the explicit fact that you are a pitiful, narcissistic imbecile.
 
It's only satire when the original manga is developed before adolescence.
 

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