Venting I want to get cancer and die

[Incelrito]

I deserve it, I live in a community full of people who support child genital mutilation in both males and females

the only way I can redeem myself by having lived in such a delusional and toxic realm is by literally either killing myself or dying of stage 4 cancer, this shit is so fucked up, why the fuck would anyone in their right mind mutilate a child's genitals, when it's obvious they know it's not okay by fucking crying?

23 year old man commits suicide 2 years after his circumcision:

'My son killed himself after circumcision'

Why did a young man kill himself two years after being circumcised?

www.bbc.com

GODDAMN JEWS AND MUSLIMS THEY ALL NEED TO BE FUCKING EXTERMINATED FOR GETTING AWAY WITH SUCH A FUCKING CRIME AGAINST HUMANITY HITLER WAS RIGHT ALL ALONG WE NEED TO KILL ALL THE JEWS AND MUSLIMS (MAINLY JEWS BECAUSE ISLAM IS A JEWISH COPYPCAT FOR HORNY SANDNIGGERS)

EXTERMINATE ALL THE AMERIMUTTS AS WELL FOR PRACTISING SUCH JEWISH HOCUS POCUS, PLEASE FOR FUCKS SAKE I DONT WANNA SEE FUTURE HUMANS SUFFER LIKE THIS ANYMORE. I DONT CARE, HUMANS CAN REBUILD A FUNCTIONAL NON-TOXIC SOCIETY ONCE WE ERADICATE ALL THESE SUBHUMANS

@subhuman

 

[Gundamcel69]

Same

 

[Incelrito]

Same

Are you willing to get it to become a martyr?

 

[iamsubhuman]

Get lung cancer and start cooking meth

 

[PLA1092]

Why do you deserve punishment for the cruelties of others?

 

[OurBoros]

Too painful

 

[Incelrito]

Why do you deserve punishment for the cruelties of others?

Because I can't do anything about it, if there's someone who can I really hope there is. All I can do is be punished so god will forgive me for living in the same country as these people who practice it

 

[PLA1092]

Because I can't do anything about it, if there's someone who can I really hope there is. All I can do is be punished so god will forgive me for living in the same country as these people who practice it

If God would punish you for that, there is no righteous God. Does he want you to individually firebomb every clinic that practices circumcision?

 

[InMemoriam]

i don't wanna get cancer i just wanna die in my sleep tomorrow

 

[fjeiru]

so whats the problem? did circumcision destroy your dick or something?

 

[Incelrito]

so whats the problem? did circumcision destroy your dick or something?

Yes and I'm very sad this barbaric practice will happen for the future generations of children if Amerimutts and Jews and Muslims still exist

 

[Window]

Absolutely ridiculous. What a waste of a life, something so fucking benign.

 

[Incelrito]

Absolutely ridiculous. What a waste of a life, something so fucking benign.

If your genitals weren't mutilated you don't feel the same pain as us. God gave us foreskin, and jews took it

 

[Window]

If your genitals weren't mutilated you don't feel the same pain as us. God gave us foreskin, and jews took it

I'm circumcised, my dick functions just fine. I'm not going to off myself because I lack an ant eater dick.

 

[DespressedCurryCel1]

Yes and I'm very sad this barbaric practice will happen for the future generations of children if Amerimutts and Jews and Muslims still exist

Im uncircumcised but why is it bad

 

[Incelrito]

I'm circumcised, my dick functions just fine. I'm not going to off myself because I lack an ant eater dick.

If you're happy with it and it doesn't affect your sex life, I'm glad then. But imagine the amount of children who get a botched circumcision who will never feel what it's like to be a human with sexual desires, I really don't want that to happen

 

[fjeiru]

If you're happy with it and it doesn't affect your sex life, I'm glad then. But imagine the amount of children who get a botched circumcision who will never feel what it's like to be a human with sexual desires, I really don't want that to happen

do you have like no feelings in your dick?

 

[Incelrito]

Im uncircumcised but why is it bad

It reduces your sexual pleasure with a woman and most importantly masturbation, thus it can affect your mental health. Rabbis, amerimutt doctors, and muslims all need to get stoned to death when they take this right from us

 

[Incelrito]

do you have like no feelings in your dick?

I only have it at the frenulum

 

[NoLooksNoLife]

I deserve it, I live in a community full of people who support child genital mutilation in both males and females

the only way I can redeem myself by having lived in such a delusional and toxic realm is by literally either killing myself or dying of stage 4 cancer, this shit is so fucked up, why the fuck would anyone in their right mind mutilate a child's genitals, when it's obvious they know it's not okay by fucking crying?

23 year old man commits suicide 2 years after his circumcision:

'My son killed himself after circumcision'

Why did a young man kill himself two years after being circumcised?

www.bbc.com

GODDAMN JEWS AND MUSLIMS THEY ALL NEED TO BE FUCKING EXTERMINATED FOR GETTING AWAY WITH SUCH A FUCKING CRIME AGAINST HUMANITY HITLER WAS RIGHT ALL ALONG WE NEED TO KILL ALL THE JEWS AND MUSLIMS (MAINLY JEWS BECAUSE ISLAM IS A JEWISH COPYPCAT FOR HORNY SANDNIGGERS)

EXTERMINATE ALL THE AMERIMUTTS AS WELL FOR PRACTISING SUCH JEWISH HOCUS POCUS, PLEASE FOR FUCKS SAKE I DONT WANNA SEE FUTURE HUMANS SUFFER LIKE THIS ANYMORE. I DONT CARE, HUMANS CAN REBUILD A FUNCTIONAL NON-TOXIC SOCIETY ONCE WE ERADICATE ALL THESE SUBHUMANS

@subhuman

Thats why I cigarette cope, Chico

 

[DespressedCurryCel1]

It reduces your sexual pleasure with a woman and most importantly masturbation, thus it can affect your mental health. Rabbis, amerimutt doctors, and muslims all need to get stoned to death when they take this right from us

Then it should be easier to go on no fap lol

 

[Incelrito]

Then it should be easier to go on no fap lol

Fapping is a blessing that god gave to incels, and to have a foreskin (a built in pocket pussy) to go with it, is heaven. And jews took it from us, they need to get exterminated

 

[Azaylias]

Get lung cancer and start cooking meth

JESSE

 

[Diddy]

I actually developed testicular cancer at one point in my life, but for some reason, the tumour never developed.

 

[Incelrito]

I actually developed testicular cancer at one point in my life, but for some reason, the tumour never developed.

Was it because of smoking?

 

[Diddy]

Was it because of smoking?

I don't smoke. Idk why I got it. I developed it when I was 14 I'm pretty sure, but I only realized it was cancer at 15 thanks to a porn ad JFL.

 

[Incelrito]

only realized it was cancer at 15 thanks to a porn ad JFL.

I see, I guess sometimes a jew is good to goyims

 

[Gundamcel69]

Are you willing to get it to become a martyr?

Yeah why not. It's not like I have anything else going on in my life.

 

[Incelrito]

Yeah why not. It's not like I have anything else going on in my life.

Why do people like us have to be born and suffer... it's cruel

 

[Indari]

23 year old man commits suicide 2 years after his circumcision:

'My son killed himself after circumcision'

Why did a young man kill himself two years after being circumcised?

www.bbc.com

gigabrutal dickpill

 

[Incelrito]

gigabrutal dickpill

Yes. Jews need to fucking die for suggesting him to do circumcision

 

[Gundamcel69]

Why do people like us have to be born and suffer... it's cruel

Idk. It's like there's a lottery system in life and we were chosen to suffer.

 

[Incelrito]

Idk. It's like there's a lottery system in life and we were chosen to suffer.

tbh

all that's left is to die and nothing will matter

 

[incel_hitler]

I mean, if u didn't see porn you wouldn't know what anyone elses dick looks like so it wouldn't matter.

 

[Intellau_Celistic]

Let's begin, before my next Duo call.

 

[Intellau_Celistic]

...

Background: Rare single nucleotide polymorphisms (SNPs) are likely to be a crucial genetic factor for human diseases, including cancer. rs78378222 is rare SNP in 3'-untranslated region (UTR) of TP53 gene leading to disturbance of 3'-end mRNA processing. The frequency of rs78378222 varies in several studied populations. The meta-analysis of 34 genome-wide association studies indicated that rs78378222 was significantly associated with an increased risk of cancer overall. Bioinformatic analysis indicates that somatic loss of the protective A allele of rs78378222 occurs in the tumor tissue of some malignant. The goal of the current study is to document the rs78378222 prevalence and evaluate the copy loss status of the protective allele A in the tumor tissue of patients with diffuse large B-cell lymphoma (DLBCL).

The rs78378222 prevalence and the copy loss of the protective allele A in the tumor tissue of diffuse large B-cell lymphoma - PubMed

At the stages of DLBCL initiation or progression a loss of the protective allele A of rs78378222 occurs. Further efforts are needed to study possible molecular mechanisms underlying somatic alterations in DLBCL in this region of the <i>TP53</i> 3'-UTR as well as functional studies to illustrate...

pubmed.ncbi.nlm.nih.gov

Rare germline variant (rs78378222) in the TP53 3' UTR: Evidence for a new mechanism of cancer predisposition in Li-Fraumeni syndrome​

Germline mutations in TP53 are the underlying defects in Li-Fraumeni syndrome (LFS) and its variant, Li-Fraumeni-like (LFL) Syndrome, autosomal dominant disorders that are characterized by predisposition to multiple early onset cancers. Here, we identified rs78378222 (A > C), a rare variant that is located in the 3' untranslated region (3' UTR) of TP53, in 7 probands (5.4%) of a cohort from LFS/LFL patients without TP53 germline mutations in the coding regions. To support its association with the LFS/LFL phenotype, we assessed p53 expression in tumor specimens and fibroblasts from rs78378222[C] carriers. Additionally, we investigated using in silico tools the evolutionary conservation and whether rs78378222[C] affects microRNA (miRNA) binding sites in the 3' UTR of TP53 mRNA. We found lower p53 protein levels in biological samples from rs78378222[C] carriers. Additionally, we showed that rs78378222[C] could interfere with a putative target site of miR-545-3p, a novel miRNA that is predicted to directly target the 3' UTR TP53. To our knowledge, this is the first description of rs78378222[C] in LFS/LFL patients. Moreover, these findings suggest that rs78378222[C] lead to haploinsufficiency of p53, a new mechanism of carcinogenesis in LFS/LFL.

Rare germline variant (rs78378222) in the TP53 3' UTR: Evidence for a new mechanism of cancer predisposition in Li-Fraumeni syndrome - PubMed

Germline mutations in TP53 are the underlying defects in Li-Fraumeni syndrome (LFS) and its variant, Li-Fraumeni-like (LFL) Syndrome, autosomal dominant disorders that are characterized by predisposition to multiple early onset cancers. Here, we identified rs78378222 (A > C), a rare variant that …

pubmed.ncbi.nlm.nih.gov

Low penetrance susceptibility to glioma is caused by the TP53 variant rs78378222 - PubMed

Our data provided strong validation of rs78378222 as a risk factor for glioma but do not support the tenet that the polymorphism being a clinically useful prognostic marker. Acquired TP53 inactivation is a common feature of glioma. As rs78378222 changes the polyadenylation signal of TP53 leading...

pubmed.ncbi.nlm.nih.gov

Conclusion: Our data provided strong validation of rs78378222 as a risk factor for glioma but do not support the tenet that the polymorphism being a clinically useful prognostic marker. Acquired TP53 inactivation is a common feature of glioma. As rs78378222 changes the polyadenylation signal of TP53 leading to impaired 3'-end processing of TP53 mRNA, the SNP has strong plausibility for being directly functional contributing to the aetiological basis of glioma.

ALFA Allele Frequency
The ALFA project provide aggregate allele frequency from dbGaP. More information is available on the project page including descriptions, data access, and terms of use.

Release Version: 20201027095038
Search:

Population	Group	Sample Size	Ref Allele	Alt Allele

Population	Group	Sample Size	Ref Allele	Alt Allele
Total	Global	35532	T=0.98762	G=0.01238
European	Sub	30360	T=0.98610	G=0.01390
African	Sub	2970	T=0.9966	G=0.0034
African Others	Sub	114	T=1.000	G=0.000
African American	Sub	2856	T=0.9965	G=0.0035
Asian	Sub	160	T=1.000	G=0.000
East Asian	Sub	132	T=1.000	G=0.000
Other Asian	Sub	28	T=1.00	G=0.00
Latin American 1	Sub	152	T=0.987	G=0.013
Latin American 2	Sub	616	T=1.000	G=0.000

 

[Magicmirror]

View attachment 713512

View attachment 713513

...

The rs78378222 prevalence and the copy loss of the protective allele A in the tumor tissue of diffuse large B-cell lymphoma - PubMed

At the stages of DLBCL initiation or progression a loss of the protective allele A of rs78378222 occurs. Further efforts are needed to study possible molecular mechanisms underlying somatic alterations in DLBCL in this region of the <i>TP53</i> 3'-UTR as well as functional studies to illustrate...

pubmed.ncbi.nlm.nih.gov

Rare germline variant (rs78378222) in the TP53 3' UTR: Evidence for a new mechanism of cancer predisposition in Li-Fraumeni syndrome​

Rare germline variant (rs78378222) in the TP53 3' UTR: Evidence for a new mechanism of cancer predisposition in Li-Fraumeni syndrome - PubMed

Germline mutations in TP53 are the underlying defects in Li-Fraumeni syndrome (LFS) and its variant, Li-Fraumeni-like (LFL) Syndrome, autosomal dominant disorders that are characterized by predisposition to multiple early onset cancers. Here, we identified rs78378222 (A > C), a rare variant that …

pubmed.ncbi.nlm.nih.gov

Low penetrance susceptibility to glioma is caused by the TP53 variant rs78378222 - PubMed

Our data provided strong validation of rs78378222 as a risk factor for glioma but do not support the tenet that the polymorphism being a clinically useful prognostic marker. Acquired TP53 inactivation is a common feature of glioma. As rs78378222 changes the polyadenylation signal of TP53 leading...

pubmed.ncbi.nlm.nih.gov

ALFA Allele Frequency
The ALFA project provide aggregate allele frequency from dbGaP. More information is available on the project page including descriptions, data access, and terms of use.

Release Version: 20201027095038
Search:

Population	Group	Sample Size	Ref Allele	Alt Allele

Population	Group	Sample Size	Ref Allele	Alt Allele
Total	Global	35532	T=0.98762	G=0.01238
European	Sub	30360	T=0.98610	G=0.01390
African	Sub	2970	T=0.9966	G=0.0034
African Others	Sub	114	T=1.000	G=0.000
African American	Sub	2856	T=0.9965	G=0.0035
Asian	Sub	160	T=1.000	G=0.000
East Asian	Sub	132	T=1.000	G=0.000
Other Asian	Sub	28	T=1.00	G=0.00
Latin American 1	Sub	152	T=0.987	G=0.013
Latin American 2	Sub	616	T=1.000	G=0.000

 

[kaan]

I'd want cancer too if I actually paid 5 dollars for a red glowing avi and username

3051

 

[SuicideIsTheOnlyWay]

I deserve it, I live in a community full of people who support child genital mutilation in both males and females

the only way I can redeem myself by having lived in such a delusional and toxic realm is by literally either killing myself or dying of stage 4 cancer, this shit is so fucked up, why the fuck would anyone in their right mind mutilate a child's genitals, when it's obvious they know it's not okay by fucking crying?

23 year old man commits suicide 2 years after his circumcision:

'My son killed himself after circumcision'

Why did a young man kill himself two years after being circumcised?

www.bbc.com

GODDAMN JEWS AND MUSLIMS THEY ALL NEED TO BE FUCKING EXTERMINATED FOR GETTING AWAY WITH SUCH A FUCKING CRIME AGAINST HUMANITY HITLER WAS RIGHT ALL ALONG WE NEED TO KILL ALL THE JEWS AND MUSLIMS (MAINLY JEWS BECAUSE ISLAM IS A JEWISH COPYPCAT FOR HORNY SANDNIGGERS)

EXTERMINATE ALL THE AMERIMUTTS AS WELL FOR PRACTISING SUCH JEWISH HOCUS POCUS, PLEASE FOR FUCKS SAKE I DONT WANNA SEE FUTURE HUMANS SUFFER LIKE THIS ANYMORE. I DONT CARE, HUMANS CAN REBUILD A FUNCTIONAL NON-TOXIC SOCIETY ONCE WE ERADICATE ALL THESE SUBHUMANS

@subhuman

This is based . To wish to die by cancer

 

[Mulattocel]

Circumcision should be outlawed

 

[kaan]

I'd want cancer too if I actually paid 5 dollars for a red glowing avi and username

3051

OP, the red glow in your username is counterfeit. when i highlight your username it stops glowing unlike paragoncels whose names glows even if you highlight it. i'd demand my money back if i was you

3078

 

[Incelrito]

OP, the red glow in your username is counterfeit. when i highlight your username it stops glowing unlike paragoncels whose names glows even if you highlight it. i'd demand my money back if i was you

3078

How unfortunate of me

 

[kaan]

I'd want cancer too if I actually paid 5 dollars for a red glowing avi and username

3051

OP, the red glow in your username is counterfeit. when i highlight your username it stops glowing unlike paragoncels whose names glows even if you highlight it. i'd demand my money back if i was you

3078

How unfortunate of me

he went crazy and posted all that because mods sold him an inferior product.

@mods - next time you sell a man something, make sure it's genuine and not counterfeit. this fiasco was avoidable

3124

 

[fortniteroleplayer]

If God would punish you for that, there is no righteous God. Does he want you to individually firebomb every clinic that practices circumcision?

Exactly.

 

[kaan]

What happened what did he do?

posted child pornography

Fuck this place, mang

If incelrito aint permabanned at the very least, Im going to be strictly a club mang from now on. A cp fag is practically succeeding at destroying our inkwell safe space n shiet, but this is why da club exists ig

incels.is

3125

 

[Linesnap99]

I just dont want to wake up again.

 

[InMemoriam]

I just dont want to wake up again.

 

[InMemoriam]

because mods sold him an inferior product.

sold him a used goblina?