Intellau_Celistic
5'3 KHHV Mentalcel
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- Joined
- Aug 26, 2021
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The brain can undergo self-repair and has the ability to compensate for functions lost after a stroke. The plasticity of the ischemic brain is influenced by several factors including aging and pharmacotherapy. Fluoxetine is an antidepressant which enhances serotonergic neurotransmission through selective inhibition of neuronal reuptake of serotonin. In clinical practice, fluoxetine alleviates the symptoms of post-stroke depression (PSD), helps motor recovery in stroke patients. In animal experiments, chronic administration of fluoxetine induces increased excitability of mature granule cells (GCs), enhancing axonal and dendritic reorganization, as well as promoting neurogenesis or angiogenesis in the dentate gurus (DG), but the effect of fluoxetine in the subventricular zone (SVZ) remains controversial. Meanwhile, chronic treatment with fluoxetine did not reverse age-dependent suppression of proliferation cells in the DG. Interestingly, although fluoxetine has been found to enhance neurogenesis in the DG in stroke rats, this property is not consistent with the behavioral recovery. More studies into this issue will be required to reveal how to translate enhanced neuronal plasticity into behavioral benefits. This review provides an update of the current knowledge about the neurogenesis and the fate of the newly generated cells after the use of fluoxetine, as well as its ability to promote a behavioral recovery after stroke in clinical and experimental results and attempts to define the therapeutic properties of fluoxetine in regenerative neuroscience.
rs10785513 | T | C | 0.380 | -0.050 | 0.012 | 1.8E-05 | --------- | 0.509 |
1000Genomes_30x | Global | Study-wide | 6404 | C=0.4182 | T=0.5818 |
1000Genomes_30x | African | Sub | 1786 | C=0.1041 | T=0.8959 |
1000Genomes_30x | Europe | Sub | 1266 | C=0.5821 | T=0.4179 |
1000Genomes_30x | South Asian | Sub | 1202 | C=0.6273 | T=0.3727 |
1000Genomes_30x | East Asian | Sub | 1170 | C=0.4957 | T=0.5043 |
1000Genomes_30x | American | Sub | 980 | C=0.430 | T=0.570 |
rs8039515 | T | G | 0.446 | -0.046 | 0.012 | 8.1E-05 | --+----+- | 0.164 |
1000Genomes_30x | Global | Study-wide | 6404 | G=0.3371 | T=0.6629 |
1000Genomes_30x | African | Sub | 1786 | G=0.0806 | T=0.9194 |
1000Genomes_30x | Europe | Sub | 1266 | G=0.5506 | T=0.4494 |
1000Genomes_30x | South Asian | Sub | 1202 | G=0.3710 | T=0.6290 |
1000Genomes_30x | East Asian | Sub | 1170 | G=0.3385 | T=0.6615 |
1000Genomes_30x | American | Sub | 980 | G=0.486 | T=0.514 |
rs860526 | T | C | 0.558 | -0.044 | 0.011 | 9.4E-05 | ------+-- | 0.877 |
rs4833619 | T | C | 0.338 | -0.042 | 0.012 | 4.4E-04 | ------++- | 0.331 |
The monoamine oxidase A (MAOA) gene has been extensively related to aggressive, impulsive and violent behaviours. Previous studies have documented the improvement of oppositional symptoms in attention deficit hyperactivity disorder (ADHD) patients with methylphenidate (MPH). However, the effect of the MAOA gene in response to MPH has not been investigated. A sample of 85 boys from an ADHD outpatient service was genotyped for the MAOA-uVNTR polymorphism. The outcome measure was the parent-rated oppositional subscale of the Swanson, Nolan and Pelham Scale – version IV. The scale was applied by child psychiatrists blinded to genotype at baseline and in the first and third months of treatment. A significant interaction between the presence of MAOA high-activity genotype and treatment with MPH over time on oppositional scores was detected during the 3 months' treatment (n=85, F2,136=4.83, p=0.009). These results suggest an effect of the MAOA-uVNTR high-activity genotype on the improvement of oppositional symptoms with MPH treatment.
I'm the mentally closest to that man, of my relatives.
It's over for indiancelsMy IQ is 0 due to being Indian
Being Indian absolutely destroyed my life
Indiancel, shortcel, skinnycel, stupidcel, poorcel, super ogrecel, spiccel, autismcelIt's over for indiancels
BrutalIndiancel, shortcel, skinnycel, stupidcel, poorcel, super ogrecel, spiccel, autismcel
When people describe individuals of a different race, it is not uncommon to hear them exclaim, “They all look the same to me!” This colloquial phrase describes one of the more reliable empirical findings in face recognition: the own-race bias (ORB). Generally, people are less able to recognize and distinguish between people of a different race than to recognize and distinguish between people of their own race (Meissner & Brigham, 2001; Slone, Brigham, & Meissner, 2000). This recognition bias is prevalent among all racial groups (Ng & Lindsay, 1994; Teitelbaum & Geiselman, 1997), but some evidence suggests the effect is most pronounced for Caucasians viewing members of racial minority groups (Meissner & Brigham, 2001). The prevalence of the bias has significant practical and societal costs. For instance, the ORB makes cross-racial eyewitness identifications highly unreliable and has dire consequences for the criminal-justice system (Doyle, 2001; Kassin, Ellsworth, & Smith, 1989).
The cognitive and social factors responsible for the ORB remain unclear (Slone et al., 2000). Theories proposing that the degree of interracial contact should be negatively associated with level of ORB have been only weakly supported (Chiroro & Valentine, 1996). A meta-analysis of 30 years of research has shown that interracial contact accounts for only about 2% of the variance in ORB across samples (Meissner & Brigham, 2001). Although negative racial attitudes are correlated with limited interracial contact, no relationship has been found between the ORB and racial attitudes, whether explicit or implicit (Ferguson, Rhodes, & Lee, 2001).
Recently, researchers have suggested that the ORB results from differences in the perception of own-race and cross-race faces (Rhodes, Brake, Tan, & Taylor, 1989; Tanaka, Kiefer, & Bukach, 2004). Generally, faces are recognized holistically; that is, a face is seen as a collective whole instead of a collection of parts (Tanaka & Farah, 1993; Maurer, Le Grand, & Mondloch, 2002). A classic demonstration of holistic face processing is the inversion effect, in which turning a face upside down, and thereby changing its spatial configuration, dramatically impairs recognition of the face; in contrast, inversion has little impact on object recognition (Farah, Wilson, Drain, & Tanaka, 1998).
Some evidence suggests that one reason for the ORB may be that cross-race faces are perceived less holistically than own-race faces (Rhodes et al., 1989; Tanaka et al., 2004). In essence, cross-race faces may be perceived more like objects. Tanaka and his colleagues (2004) recently found that people rely on more holistic information for recognizing own-race faces than for recognizing cross-race faces. In addition, the inversion effect is more disruptive to recognizing own-race faces than recognizing cross-race faces (Rhodes et al., 1989). Facial recognition has been localized to an area of the brain dubbed the fusiform face area (FFA; Tong, Nakayama, Moscovitch, Weinrib, & Kan-wisher, 2000).1 However, the FFA is less active in response to cross-race faces than own-race faces (Golby, Gabrieli, Chiao, & Eberhardt, 2001), which again suggests that cross-race faces are perceived less holistically than own-race faces.
An additional explanation for the ORB is that when viewing cross-race faces, people focus more on cues of racial category than on cues of individual identity (Levin, 2000; Maclin & Malpass, 2003). Race is perhaps the most salient social category. Montepare and Opeyo (2002) demonstrated that racial differences are detected faster than other social differences, such as gender, age, or emotional expression. Evoked-response potentials are about 50% faster responding to racial differences than gender differences (Ito & Urland, 2003). People are also significantly faster at racially categorizing cross-race faces than own-race faces (Levin, 1996). Levin (2000) showed that an enhanced ability to categorize cross-race faces by race is correlated with an impaired ability to recognize cross-race faces; this finding suggests that the ORB occurs because encoding information about racial category interferes with encoding individuating information.
The role of racial categorization is also highlighted by Maclin and Malpass (2003), who argued that the mere act of categorizing a face by race alters how individual facial features are represented in memory. For example, after categorizing a face as “African American,” one may remember the skin tone as darker than it actually was and facial features as more like a prototypical racial exemplar than they were. Maclin and Malpass concluded that the altered perception of cross-race faces due to the categorization process may underlie the ORB.
Even though the underlying mechanisms remain unclear, the ORB has proven to be a very robust psychological phenomenon, both prevalent and persistent (Meissner & Brigham, 2001). One study did show that hours of intensive training could reduce the magnitude of the ORB, but the effect was short-lived, and 1 week later there was no difference between trained and untrained participants (Lavrakas, Buri, & Mayzner, 1976). A new perspective on emotions, however, led us to test whether experienced positive emotions can reduce the ORB.
The benefits of positive emotions extend beyond the good feelings associated with them. Fredrickson's (2001) broaden-and-build theory states that positive emotions are evolved adaptations that in the moment broaden a person's “thought-action” repertoire and over time build that person's enduring personal resources. Positive emotions may have long-term survival benefits by making people more open-minded and flexible, and ultimately better able to see and take advantage of more opportunities in the environment.
One aspect of the broaden-and-build theory, the broaden hypothesis, predicts that positive emotions widen the scope of attention and literally enhance an individual's ability to see the “big picture” (Fredrickson & Branigan, 2005). Several studies have demonstrated that positive emotions facilitate holistic attentional processes (Basso, Schefft, Ris, & Dember, 1996; Derryberry & Tucker, 1994). Studies investigating global versus local attentional processes have found that individuals with negative emotional traits, like anxiety, focus more on local elements, whereas individuals with positive emotional traits, like optimism, focus more on global elements (Basso et al., 1996).
When positive or negative feedback is used to induce mood during global-local tasks, failure feedback produces a local bias, whereas success feedback produces a global bias (Derryberry & Tucker, 1994). We have additional evidence linking positive emotions to more holistic perceptions. In one experiment, we showed that induced positive emotions produced global biases on a global-local choice task (Fredrickson & Branigan, 2005). Recently, we found that the frequency of Duchenne smiles was positively correlated with faster reaction times to global relative to local targets (Johnson, Waugh, Wager, & Fredrickson, 2004). Because one explanation for the ORB is weaker holistic encoding of cross-race faces than own-race faces (Rhodes et al., 1989), we propose that positive emotion may reduce the ORB by facilitating holistic perceptions.
An additional prediction of the broaden-and-build theory is that positive emotions help to build social resources, perhaps by diminishing the salience of group differences. Positive affect is known to produce more inclusive categorization strategies, which increase perceived similarities between social groups (Isen, Niedenthal, & Cantor, 1992). Dovidio, Isen, and their colleagues have found that induced positive affect promotes the use of more inclusive social categories and more superordinate group representations, making participants more likely to view each of their groups as part of one larger, all-encompassing group (Dovidio, Gaertner, Isen, & Lowrance, 1995). Positive affect fosters a common in-group identity in which individuals are more willing to see “them” as “us” (Dovidio, Isen, Guerra, Gaertner, & Rust, 1998). However, we do not know whether these more inclusive social categorizations also extend to racial perceptions. An intriguing possibility is that by promoting a common in-group identity, positive emotions could reduce the ORB by reducing the salience of racial differences.
Possible mechanisms aside, the present experiments were designed to test the initial hypothesis that positive emotions, relative to negative emotions or neutral states, reduce the ORB in facial recognition. Because recognition tasks require at least two stages, an encoding (learning) stage and a later recognition (testing) stage, we conducted a pair of experiments to examine the influence of emotions on encoding (Experiment 1) and recognizing (Experiment 2) pictures of Black and White people of both genders. Brief video segments were used to induce joy, fear, or a neutral state. Procedures for Experiments 1 and 2 were identical except for the timing of the emotion induction. In Experiment 1, we induced joy, fear, or neutrality prior to face encoding, whereas in Experiment 2, we induced these same states prior to the recognition test. We restricted our analyses to participants identifying themselves as Caucasian.