Toxic Femininity Children with autistic mothers have 5.4% chance to have autism, while children with autistic fathers have only 1.5% chance of having autism.

[Murder Mario]

Can Autistic People Have Kids?

In this article, we will explore the possibilities and challenges that autistic people may face when it comes to having children.

www.thetreetop.com

According to a study published in Molecular Autism, children born to mothers with autism have a 5.4% chance of also being diagnosed with the disorder, while children born to fathers with autism have only a 1.5% chance.

Furthermore:

It is estimated that 1 in 54 children in the United States are diagnosed with autism spectrum disorder (ASD).

1/54 = 1.85%, which means autistic fathers passing down their autistic genes (1.5%) is less likely than the average rate.

Women are to blame for autism, plain and simple.

 

[TheIncelPill]

Wait, seriously???

Dude, this is white pilling.

Too incompetent to have sex and raise kids, but good to know.

 

[ElTruecel]

I developed autism because I was an only child with older parents

 

[Murder Mario]

I developed autism because I was an only child with older parents

Only child has nothing to do with it. The older mom does. The father’s role being old isn’t as important.

 

[ElTruecel]

Only child has nothing to do with it. The older mom does. The father’s role being old isn’t as important.

what age would you say someone becomes too old to bear kids without having side affects

 

[Murder Mario]

what age would you say someone becomes too old to bear kids without having side affects

Mothers around early 30s the chances go up, 35+ very high

Fathers are tricky, it depends on how well he takes care of himself. Maybe 50s+?

 

[IceStorm]

And if their older they also have a higher chance of having a Kid witb Autism
Also Men get more of their genes from their Mother so it makes sense

@30klhlvwizard

 

[ElTruecel]

Ever heard of Chris Chan?

Of course

 

[Intellau_Celistic]

I tried this, and a disabled hole immediately tried to use it against me.

The Psychiatric Risk Gene Transcription Factor 4 (TCF4) Regulates Neurodevelopmental Pathways Associated With Schizophrenia, Autism, and Intellectual Disability​

Genetic variants in and around the transcription factor 4 (TCF4) gene are associated with range of disorders that are frequently associated with cognitive dysfunction.1–3 The most recent schizophrenia GWAS reported three independent single nucleotide polymorphisms (SNPs) in TCF4 that surpassed the threshold for genome wide significance.4 Intriguingly, rare TCF4 single nucleotide variants (SNVs) have also been described in schizophrenia patients, although their impact on the function of the protein has not been established.5,6 In addition to the genetic studies in schizophrenia, TCF4 variants are associated with early information processing and cognitive markers, some of which are schizophrenia endophenotypes.7–10 Damaging TCF4 mutations have also been described in large-scale genotyping studies in patients with ID, neurodevelopmental disorders, and most recently ASD.11–15 Haploinsufficiency of TCF4 causes Pitt–Hopkins syndrome (PTHS); a rare form intellectual disability (ID) associated with characteristic facial features, autonomic dysfunction, and behavioral traits that resemble autism spectrum disorder (ASD).16–19 Collectively, these studies implicate TCF4 in a range of neurodevelopmental disorders.

CF4 is a member of the basic helix-loop-helix (bHLH) family of proteins.20–22 For the purposes of disambiguation, it should be noted that TCF4 (Gene ID: 6925) described herein should not be confused with T-cell factor 4 (Gene ID: 6934, official gene symbol, TCF7L2) since they can share the same acronym. TCF4 and its paralogues, collectively known as E-proteins, interact with other bHLH proteins to regulate DNA binding specificity and transcriptional activity at promoters and enhancers that contain E-boxes (5′-CANNTG).2,20,23 The human TCF4 gene encodes multiple protein isoforms of which only the major isoforms TCF4-A and TCF4-B have been characterized in detail.24 In neurons, TCF4 regulates the intrinsic excitability of pyramidal cells of the prefrontal cortex and has been shown to attenuate neurite branching.25,26 Furthermore, haploinsufficiency of Tcf4 in mice affects gene expression and DNA methylation in the brain, leading to enhanced long-term potentiation, learning and memory deficits, and autistic-like behavior.22,25,26 By contrast, mice over-expressing Tcf4 in the brain display deficits in sensorimotor gating, fear conditioning, and circadian processes as well as impairments in attentional and behavioral anticipation.7,27

Converging evidence for a pseudoautosomal cytokine receptor gene locus in schizophrenia​

​

Schizophrenia is a strongly heritable disorder, and identification of potential candidate genes has accelerated in recent years. Genomewide scans have identified multiple large linkage regions across the genome, with fine-mapping studies and other investigations of biologically plausible targets demonstrating several promising candidate genes of modest effect. The recent introduction of technological platforms for whole-genome association (WGA) studies can provide an opportunity to rapidly identify novel targets, although no WGA studies have been reported in the psychiatric literature to date. We report results of a case-control WGA study in schizophrenia, examining approximately 500 000 markers, which revealed a strong effect (P=3.7 x 10(-7)) of a novel locus (rs4129148) near the CSF2RA (colony stimulating factor, receptor 2 alpha) gene in the pseudoautosomal region. Sequencing of CSF2RA and its neighbor, IL3RA (interleukin 3 receptor alpha) in an independent case-control cohort revealed both common intronic haplotypes and several novel, rare missense variants associated with schizophrenia. The presence of cytokine receptor abnormalities in schizophrenia may help explain prior epidemiologic data relating the risk for this illness to altered rates of autoimmune disorders, prenatal infection and familial leukemia.

 

[Zer0/∞]

Breeders just want to cause more problems

 

[Intellau_Celistic]

These people don’t know what they are talking about....I’m assuming none of them have autism

I wonder how many PubMed articles were inspired by incels.

Anyway:

 

[Intellau_Celistic]

It won’t start.



over

i don't know what all that shit mean but i am probably totally sane person or maybe not, i really don't care since i can talk with people normally without any problem
good luck bro

Systemizing is genetically correlated with autism and is genetically distinct from social autistic traits​

Abstract​

The hypersystemizing theory of autism suggests that autistic individuals, on average, have superior attention to detail, and a stronger drive to systemize. Systemizing involves identifying input-operation-output relationships. Here, we report the results of genome-wide association studies (GWAS) of systemizing measured using the Systemizing Quotient - Revised in n = 51,564 individuals. We identify three genome-wide significant loci: Two of these were significant in the non-stratified GWAS: rs4146336 on chromosome 3 (P = 2.58×10−8) and rs1559586 on chromosome 18 (P = 4.78×10−8). In addition, we also identified a significant locus in the males-only GWAS (rs8005092 on chromosome 14, P = 3.74×10−8). We find that 12%± 1.2 of the variance in systemizing is captured by SNPs (P=1.2×10−20). We identify a positive genetic correlation between autism and systemizing (rg = 0.26±0.06; P = 3.35×10−5), which is independent of genetic contribution to educational attainment. We further demonstrate that genetic risk for autism from systemizing is genetically distinct from genetic risk emerging from social autistic traits, suggesting distinct shared genetics between autism and social and non-social traits. Our results highlight the importance of considering both social and non-social autistic traits in elucidating the genetic architecture of autism.

...

Common genetic risk variants identified in the SPARK cohort support DDHD2 as a candidate risk gene for autism​

Autism spectrum disorder (ASD) is a highly heritable neurodevelopmental disorder. Large genetically informative cohorts of individuals with ASD have led to the identification of a limited number of common genome-wide significant (GWS) risk loci to date. However, many more common genetic variants are expected to contribute to ASD risk given the high heritability. Here, we performed a genome-wide association study (GWAS) on 6222 case-pseudocontrol pairs from the Simons Foundation Powering Autism Research for Knowledge (SPARK) dataset to identify additional common genetic risk factors and molecular mechanisms underlying risk for ASD. We identified one novel GWS locus from the SPARK GWAS and four significant loci, including an additional novel locus from meta-analysis with a previous GWAS. We replicated the previous observation of significant enrichment of ASD heritability within regulatory regions of the developing cortex, indicating that disruption of gene regulation during neurodevelopment is critical for ASD risk. We further employed a massively parallel reporter assay (MPRA) and identified a putative causal variant at the novel locus from SPARK GWAS with strong impacts on gene regulation (rs7001340). Expression quantitative trait loci data demonstrated an association between the risk allele and decreased expression of DDHD2 (DDHD domain containing 2) in both adult and prenatal brains. In conclusion, by integrating genetic association data with multi-omic gene regulatory annotations and experimental validation, we fine-mapped a causal risk variant and demonstrated that DDHD2 is a novel gene associated with ASD risk.

Being schizophrenic is fucking hell. I should be thankful I'm not autistic aswell. Life's already shitty enough with my schizo ass.

Sorry for your loss.

 

[SeetheBot9000]

It's pretty simple, autistic females still have a much higher chance of reproducing than autistic males. Ergo, if autism is passed in some way genetically, it is much more likely to come from the mother.

 

[Murder Mario]

It's pretty simple, autistic females still have a much higher chance of reproducing than autistic males. Ergo, if autism is passed in some way genetically, it is much more likely to come from the mother.

That doesn’t explain why when there is an autistic father, he is less likely to pass it on.

 

[SeetheBot9000]

That doesn’t explain why when there is an autistic father, he is less likely to pass it on.

ahhhhhhhhh shit, you're right. Misunderstood the title. Well uhhhhhhhhh maybe autism is mainly carried on the X chromosome? Idk

 

[Intellau_Celistic]

That doesn’t explain why when there is an autistic father, he is less likely to pass it on.

I'm obliging only because of the vileness.

1000Genomes_30x	Global	Study-wide	6404	A=0.7820	T=0.2180
1000Genomes_30x	African	Sub	1786	A=0.6249	T=0.3751
1000Genomes_30x	Europe	Sub	1266	A=0.9637	T=0.0363
1000Genomes_30x	South Asian	Sub	1202	A=0.8544	T=0.1456
1000Genomes_30x	East Asian	Sub	1170	A=0.6607	T=0.3393
1000Genomes_30x	American	Sub	980	A=0.890	T=0.110