Experiment Would you rather receive $1,000,000 or be cured of your autism?

[Aspergcel]

I’d rather get cured of autism. What about you guys?

 

[NihilisticSoul]

I haven't been diagnosed with Autism but i probably have it tbh.

I'd take the million dollars

 

[parzurnacs]

Still being based and having the million dollars

 

[NuclearCel]

Million Bucks Ez.

 

[Aspergcel]

My non-traits are not debilitating enough to pass up a million dollars . I'll go with the million to be able to NEET comfily and not wake up to my alarm clock to be a wagie around normies who wish me dead.

What’s your job?

 

[Aspergcel]

Still being based and having the million dollars

What would you do with the money?

 

[Aspergcel]

I haven't been diagnosed with Autism but i probably have it tbh.

I'd take the million dollars

What would you spend it on?

 

[NihilisticSoul]

What would you spend it on?

Plastic surgery
an Apartment

etc

 

[PersonalityChad]

Pretty difficult choice ngl, but i'm going with the 1 million bucks.

 

[Intellau_Celistic]

Mutational Load:

The Psychiatric Risk Gene Transcription Factor 4 (TCF4) Regulates Neurodevelopmental Pathways Associated With Schizophrenia, Autism, and Intellectual Disability​

Genetic variants in and around the transcription factor 4 (TCF4) gene are associated with range of disorders that are frequently associated with cognitive dysfunction.1–3 The most recent schizophrenia GWAS reported three independent single nucleotide polymorphisms (SNPs) in TCF4 that surpassed the threshold for genome wide significance.4 Intriguingly, rare TCF4 single nucleotide variants (SNVs) have also been described in schizophrenia patients, although their impact on the function of the protein has not been established.5,6 In addition to the genetic studies in schizophrenia, TCF4 variants are associated with early information processing and cognitive markers, some of which are schizophrenia endophenotypes.7–10 Damaging TCF4 mutations have also been described in large-scale genotyping studies in patients with ID, neurodevelopmental disorders, and most recently ASD.11–15 Haploinsufficiency of TCF4 causes Pitt–Hopkins syndrome (PTHS); a rare form intellectual disability (ID) associated with characteristic facial features, autonomic dysfunction, and behavioral traits that resemble autism spectrum disorder (ASD).16–19 Collectively, these studies implicate TCF4 in a range of neurodevelopmental disorders.

CF4 is a member of the basic helix-loop-helix (bHLH) family of proteins.20–22 For the purposes of disambiguation, it should be noted that TCF4 (Gene ID: 6925) described herein should not be confused with T-cell factor 4 (Gene ID: 6934, official gene symbol, TCF7L2) since they can share the same acronym. TCF4 and its paralogues, collectively known as E-proteins, interact with other bHLH proteins to regulate DNA binding specificity and transcriptional activity at promoters and enhancers that contain E-boxes (5′-CANNTG).2,20,23 The human TCF4 gene encodes multiple protein isoforms of which only the major isoforms TCF4-A and TCF4-B have been characterized in detail.24 In neurons, TCF4 regulates the intrinsic excitability of pyramidal cells of the prefrontal cortex and has been shown to attenuate neurite branching.25,26 Furthermore, haploinsufficiency of Tcf4 in mice affects gene expression and DNA methylation in the brain, leading to enhanced long-term potentiation, learning and memory deficits, and autistic-like behavior.22,25,26 By contrast, mice over-expressing Tcf4 in the brain display deficits in sensorimotor gating, fear conditioning, and circadian processes as well as impairments in attentional and behavioral anticipation.7,27

Psychiatric Risk Gene Transcription Factor 4 (TCF4) Regulates Neurodevelopmental Pathways Associated With Schizophrenia, Autism, and Intellectual Disability​

 

[IncelKing]

My non-traits are not debilitating enough to pass up a million dollars . I'll go with the million to be able to NEET comfily and not wake up to my alarm clock to be a wagie around normies who wish me dead.

Same. Just 1 million would set me for life

 

[kaan]

I don't have autism

 

[Incline]

I’d rather get cured of autism. What about you guys?

1 million easy

I can get a house and live out my days without worrying about being poor sounds like a dream

sure ill still be an autist but with that kind of money it doesnt rly matter tbh

 

[Intellau_Celistic]

I don't have autism

Yeah.

ALFA Allele Frequency
The ALFA project provide aggregate allele frequency from dbGaP. More information is available on the project page including descriptions, data access, and terms of use.

Release Version: 20201027095038
Search:

Population	Group	Sample Size	Ref Allele	Alt Allele

Population	Group	Sample Size	Ref Allele	Alt Allele
Total	Global	97800	A=0.93291	C=0.06709, G=0.00000
European	Sub	80228	A=0.94664	C=0.05336, G=0.00000
African	Sub	6000	A=0.8507	C=0.1493, G=0.0000
African Others	Sub	202	A=0.827	C=0.173, G=0.000
African American	Sub	5798	A=0.8515	C=0.1485, G=0.0000
Asian	Sub	224	A=1.000	C=0.000, G=0.000
East Asian	Sub	184	A=1.000	C=0.000, G=0.000

 

[Magicmirror]

Yeah.

ALFA Allele Frequency
The ALFA project provide aggregate allele frequency from dbGaP. More information is available on the project page including descriptions, data access, and terms of use.

Release Version: 20201027095038
Search:

Population	Group	Sample Size	Ref Allele	Alt Allele

Population	Group	Sample Size	Ref Allele	Alt Allele
Total	Global	97800	A=0.93291	C=0.06709, G=0.00000
European	Sub	80228	A=0.94664	C=0.05336, G=0.00000
African	Sub	6000	A=0.8507	C=0.1493, G=0.0000
African Others	Sub	202	A=0.827	C=0.173, G=0.000
African American	Sub	5798	A=0.8515	C=0.1485, G=0.0000
Asian	Sub	224	A=1.000	C=0.000, G=0.000
East Asian	Sub	184	A=1.000	C=0.000, G=0.000

Thank you

 

[Michael15651]

Autism doesn’t exist so I’ll take the money

 

[Michael15651]

What would you spend it on?

Hookers and cocaine

 

[ADHD_cel]

Money all the day. When I’m rich I don’t have to give a fuck about normie’s opinions and can enjoy my autistic hobbies at will, kek

 

[kaan]

Yeah.

ALFA Allele Frequency
The ALFA project provide aggregate allele frequency from dbGaP. More information is available on the project page including descriptions, data access, and terms of use.

Release Version: 20201027095038
Search:

Population	Group	Sample Size	Ref Allele	Alt Allele

Population	Group	Sample Size	Ref Allele	Alt Allele
Total	Global	97800	A=0.93291	C=0.06709, G=0.00000
European	Sub	80228	A=0.94664	C=0.05336, G=0.00000
African	Sub	6000	A=0.8507	C=0.1493, G=0.0000
African Others	Sub	202	A=0.827	C=0.173, G=0.000
African American	Sub	5798	A=0.8515	C=0.1485, G=0.0000
Asian	Sub	224	A=1.000	C=0.000, G=0.000
East Asian	Sub	184	A=1.000	C=0.000, G=0.000

Why is the sample size for Europeans so high compared to other races? Especially Asians.

 

[Intellau_Celistic]

Why is the sample size for Europeans so high compared to other races? Especially Asians.

The data was collected only from approved studies in the NIH database, so there is a deficit of certain ethnicities.

 

[ordinaryotaku]

My autism doesn't inhibit me much. 1 milly would go a long way for me, though. I would drop out of this shit uni, pay the rest of it off, and find other stuff to do.

 

[Ahnfeltia]

Million Bucks Ez.

 

[kaan]

Yeah.

ALFA Allele Frequency
The ALFA project provide aggregate allele frequency from dbGaP. More information is available on the project page including descriptions, data access, and terms of use.

Release Version: 20201027095038
Search:

Population	Group	Sample Size	Ref Allele	Alt Allele

Population	Group	Sample Size	Ref Allele	Alt Allele
Total	Global	97800	A=0.93291	C=0.06709, G=0.00000
European	Sub	80228	A=0.94664	C=0.05336, G=0.00000
African	Sub	6000	A=0.8507	C=0.1493, G=0.0000
African Others	Sub	202	A=0.827	C=0.173, G=0.000
African American	Sub	5798	A=0.8515	C=0.1485, G=0.0000
Asian	Sub	224	A=1.000	C=0.000, G=0.000
East Asian	Sub	184	A=1.000	C=0.000, G=0.000

The data was collected only from approved studies in the NIH database, so there is a deficit of certain ethnicities.

do you know what the population is that they are studying? somewhere in america obviously but what confuses me is that the sample size of red indians and latinos is absolutely zero. there should be at least some.

 

[kaan]

Yeah.

ALFA Allele Frequency
The ALFA project provide aggregate allele frequency from dbGaP. More information is available on the project page including descriptions, data access, and terms of use.

Release Version: 20201027095038
Search:

Population	Group	Sample Size	Ref Allele	Alt Allele

Population	Group	Sample Size	Ref Allele	Alt Allele
Total	Global	97800	A=0.93291	C=0.06709, G=0.00000
European	Sub	80228	A=0.94664	C=0.05336, G=0.00000
African	Sub	6000	A=0.8507	C=0.1493, G=0.0000
African Others	Sub	202	A=0.827	C=0.173, G=0.000
African American	Sub	5798	A=0.8515	C=0.1485, G=0.0000
Asian	Sub	224	A=1.000	C=0.000, G=0.000
East Asian	Sub	184	A=1.000	C=0.000, G=0.000

The data was collected only from approved studies in the NIH database, so there is a deficit of certain ethnicities.

the numbers don't add up 80228 + 6000 + 202 + 5798 + 224 + 184 = 92636. not 97800
that's off by 5164. The NIH has been compromised. i advise you stop utilization of their data.

 

[kaan]

shit i thought this was a sewers thread.

 

[Puppeter]

You dont have autism just lack of social interconnections

 

[autisticmanchild]

I'd get rid of autism. As a normie my potential is only limited by laziness so I could get that money as well.

 

[Rasnov]

I haven't been diagnosed with Autism but i probably have it tbh.

I'd take the million dollars

 

[nystagmuscel]

Cure me tbh

 

[DepravedAndDeprived]

Still being based and having the million dollars

 

[Saint Cho]

I wouldn't give a fuck about having no friends as a millionaire.

 

[Glerforpus]

I don’t think I have autism but the money is well appreciated

 

[proudweeb]

I'll take a milli, buy VTSAX and retire RIGHT NOW

Life with autism (well, ass purger's in my case) isn't too bad if you don't have to deal with normies daily

 

[TouhouMathcel]

Mathematically speaking, one million dollars is enough for just a couple of years of NEET, which is an unsuccessful investment. So imo it's better to get cured of autism and become an NT

 

[Firefly]

autism is a meme​

 

[PopeOfCope]

autism is a meme​

Diagnosed at 3. It's really not.

 

[Caesercel]

You mean actual clinical autism? I don't have that

 

[asdfghjqbbbb]

Still being based and having the million dollars

right on