Balding Subhuman
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Nucleus accumbens dichotomically controls social dominance in male mice
Nucleus accumbens dichotomically controls social dominance in male mice - Neuropsychopharmacology
Social dominance versus social submissiveness is a basic behavioral trait of social animals such as human beings and laboratory mice. The brain regions associated with this behavior have been intensely investigated, and early neuroimaging research on human subjects implies that the nucleus...
www.nature.com
In the modern egalitarian society, the hierarchical structure manifests in more subtle forms, such as socioeconomic status in society or peer competition and bullying in work places and schools. Indeed, hierarchical social status in the modern society has been regarded as the most important factor determining one’s physical and mental health [5,6,7,8,9,10,11]. Therefore, understanding the biological mechanism underlying hierarchical social status, more specifically, social dominance versus social submissiveness, is useful both socioeconomically and biomedically.
In this study, laboratory mice were used to establish the role that the local neuronal circuitry, specifically the D1R-MSNs and D2R-MSNs in the shell and core subregions of the NAc, plays in encoding social dominance. It was revealed that the postsynaptic strengths of excitatory synapses onto the shell D1R-MSNs and the core D2R-MSNs are respectively negatively and positively correlated with social dominance; and correspondingly, their activities respectively suppress and promote social dominance.
The Roles of Dopamine D2 Receptor in the Social Hierarchy of Rodents and Primates
The Roles of Dopamine D2 Receptor in the Social Hierarchy of Rodents and Primates - Scientific Reports
Dopamine (DA) plays significant roles in regulation of social behavior. In social groups of humans and other animals, social hierarchy exists, which is determined by several behavioral characteristics such as aggression and impulsivity as well as social affiliations. In this study, we...
www.nature.com
In this study, we examined the effects of pharmacological manipulation to inhibit D2 receptor function in socially housed macaques and mice. We specifically selected macaques and mice, since these species exhibit rigorous linear social hierarchy in their social groups, but distinct mechanisms seem to be involved in construction of social hierarchy between them. Associations between striatal D2 receptor expression and social rank or social status in non-human primates26 and humans27 have been already reported, with higher social rank/status subjects exhibiting higher striatal D2 receptor expression. Thus, we hypothesized that administration of the D2 receptor antagonist attenuated social dominance of drug-treated rodents and primates living in social groups.
In conclusion, DA D2 receptor function may play an important role in animals living in hierarchical society, especially among high social class animals in groups, and this role is common across different species.In this study, we found that D2 antagonist administration to higher social rank macaques and mice housed in social groups attenuated social dominance, whereas the same drug treatment did not alter social dominance in lower social rank animals. These findings are consistent with the studies showing that higher social class non-human primates26 and human subjects27 exhibit higher D2 receptor expression in the striatum. Thus, D2 receptor stimulation appears to promote some behavioral traits that are required to gain higher social class.
This is very esoteric knowledge that I hope you take with you because incels need this information more than anyone else.