LifeFuel Why Opioids work and don't work for inceliety and other solutions

[MajorThomas666]

Certain endogenous opioids play a significant role in social status, well-being, and fear extinction. Usually people who harbor neurotypical behaviors have a higher social status than those who do not. Here's why:

Endogenous opioids—endorphins and enkephalins—increase social bonding, feeling of reward, and are released during positive social interactions (e.g., hugging, bonding, trust-building).

Negative social interactions create negative feedback loops—incels are mightily susceptible, and not entirely of their own doing—which increase stress, avoidance, anxiety and fear.

There is a direct correlation between higher social status and natural opioid release, which reinforces behaviors that are beneficial for social cohesion and overall mental health.

When neurotypicals contend that incels are better off living alone and sexless because "life is more than just sex and community," they forget to mention that human health is derived from positive social interactions and sex, both of which release endogenous opioids while resensitizing the euphoric mu opiod receptors due to positive feedback loops.

When we observe humans living in this realm of existence, it's as if viewing an entirely different species. Neurotypicals appear to behave foreign to incels because their brain chemistry is uniquely different.

Neurotypicals are usually more successful because opioids as regulators of social stress, so with each positive interaction they can more easily climb the social ladder and feel confidant in who they are.

A neurotypical can be a sociopath, psychopath, or a stone, cold killer, as long as his/her interactions are positive, and his/her sins stay hidden, society will coddle and uplift.

Avoidance behavior, even sickness syndrome—most of society will abandon you the moment who acquire a chronic illness—decreases endogenous opioid release while amplifying the density of kappa opioid receptors, which, while a reliever of physical pain, causes significant dysphoria, fear, dread and anxiety.

God literally made it so that humans, as social beings, feel a rush of heavenly euphoria from positive social interactions, while incels and shy folks who are marginalized, ostracized, their pain obfuscated by society, are left with a shitty opioid that relieves physical body pain but sends your mind to the looney bin.

The kappa-opioid receptor (KOR) works directly against extinction.

I've tried a synthetic kappa-opioid receptor agonist and all I can say is that if you want to take a drug from Satan, that's your best bet.

Everything about a social interaction is foreign, even if you already have anxiety. You feel derealized, depersonalized, as if looking out of a cave at the world in total dread, feeling terror every time someone speaks a word. A nightmare in hell. This is the full spectrum of emotions a lonely, socially deprived incel will experience by way of total inceliety 'ascension.'

Kappa is activated during stress, SOCIAL DEFEAT, HUMILIATION, and produces dysphoria, withdrawal, freezing, and is overactive in PTSD, Social anxiety, Chronic stress, diseases such as Huntington's, Lupus, and in infectious diseases such as Borreliosis—the highest suicide rats among all diseases.

So kappa or KOR activation, while it relieves physical pain, strengthens fear memories, increases social avoidance and reduces dopamine. The end result being a double-edged sword that feeds our terror further.
Literally chronic social fear = high KOR tone, low MOR tone. It's not just in your head, it's not psychosomatic, you cannot just "rethink shit and feel better," it's a physical neurotransmitter imbalance due to negative interactions with the outside world.

What's the most common full agonist of the Kappa opioid receptor?

Want to guess?

Salvia. Yes, the herb boomers and Pakis sold to HS kids at gas stations. The worst hallucinogenic plant on the planet that sends you straight to hell.

Might this be the universes' way of telling us to not hide away or is it telling us to do the very opposite?

So we've learned that endogenous opioids act as a buffer to social stress, where higher levels buffer the negative emotional effects of social exclusion and social conflict.

So this would suggest opioids, in moderation, help regulate emotional states and reduce the negative emotional impact of fear. Clearly opioids cannot be taken longterm as they desensitize receptors and are addictive.

So what compounds enhance opioid resensitization that would be optimal for long-term fear extinction?

Well, first, how exactly do opioids enhance fear extinction?

They do this by modulating emotional memory during the extinction process—specifically μ-opioid (MOR) receptors in the prefrontal cortex and amygdala, where fear response is most prevalent.

Activation of these receptors reduces the emotional intensity of the fear memory, which helps facilitate the extinction process while promoting neuroplasticity and dopamine release, both of which strengthen new, non-fearful associations. So neurotypicals are always high on life. "Fuck you, YOU're ruining my high, incel!"

In animals, opioid receptor agonists (such as morphine or oxycontin) have been shown to increase extinction learning by reducing the anxiety or distress related to fearful memories, modulating emotional salience—essentially making the exposure to a feared stimulus less aversive, which makes it easier to extinguish the fear response. However, longterm use has the opposite impact.

Fear extinction is not erasing fear, but learning a new “safe” memory that inhibits the old fear memory. Opioid signaling is involved because extinction is emotionally costly for the brain—society tends to ignore this if the sufferer is short or ugly.

In more technical terms, opioid receptors act as an internal emotional pain buffer that permits extinction learning. If distress is too high, extinction fails. If distress is fully numbed, learning also fails. There's an optimal balance that neurodivergents cannot normalize.
μ-opioid receptor (MOR) are most important and are activated by endorphins. MOR literally encodes relief, safety, and social comfort, and are highly expressed in the Amygdala, Prefrontal cortex, Periaqueductal gray (threat modulation) — all critical for fear extinction.

What MOR does is reduce aversive prediction error such as "this is bad", "stay away," "I'm anxious," and does it completely subconsciously. Even if the feelings are legitimate, it's better to feel euphoric and grounded in the face of it all than anxious in the fetal position.

So MOR encodes in the brain that the feared thing happened, but I survived and it wasn’t catastrophic. You see many Staceys, Beckys and Chads on social media spew, "pain is gain," or "you have to put yourself into uncomfortable situations to progress."

Here's the catch. Their fear isn't ours. Our fear is 100 fold, theirs is euphoria and anxious excitement, perhaps a quiver of the gonads, ours is dread, even terror.

We know that blocking MOR (e.g., naloxone) impairs fear extinction considerably, and in animals models rodents will avoid other rodents.

So how can we, as incels with inceliety, embrace our livelihood (this goes for NEETS as well—the most hated of all peoples) and resensitize opioid receptors?

It has been recently discovered that the ancient tree, Gingko biloba, which survived multiple mammalian extinction events, has been found to enhance opioid receptor sensitivity significantly by modulating dopamine and serotonin systems and increasing the reactivity of μ-opioid receptors—the feel good opioid. This could theoretically enhance the effect of opioids on fear extinction. And I believe it has worked for me.

My initial bout with synthetic MOR enhancing opioids occurred after a kidney stone. Upon ingestion of multiple kinds, I had this epiphany that I was anxiety free for once in my life, and talked to two stacey nurses, who were gossiping about other men and women, and one of whom I knew from high school, but I had zero anxiety, and talked to them despite feeling like hell. I didn't care that my life was/is in shambles and theirs mogged mine to oblivion. I didn't stutter, I just lived in the moment despite the existential hilarity of it all.

Multiple studies have found that Gingko improves the function of opioid receptors (μ-opioid receptors in particular), making them more responsive to endogenous opioids. This means greater social reward and better stress regulation from social interactions (both key in emotional regulation).

The catch is that you cannot go buying any old Gingko supplement. 70% of all Gingko supplements are adulterated and not standardized. More than half the brands lie about their constitutes. The supplement industry is full of criminals.

The only Gingko on the market that is tested, standardized and has a significant amount of the chemical in Gingko that enhances fear extinction is from Nootropics Depot.

So synthetic opioids, even natural opioids like Kratom, will certainly work for short term use and strongly enhance extinction learning, even when microdosimg, “overwriting” fearful subconscious memories, but have significant and contradictory long-term risks, including addiction, tolerance, and withdrawal; cognitive learning blockage, emotional blunting and anhedonia are also horrible side effects.

Why not take herbs that raise our natural opioid reponse longterm?

Gingko and Gotu Kola are two options. The latter is a anxiolytic that can improve fear extinction by enhancing prefrontal cortex control over the amygdala. It’s beneficial for people with social anxiety, like me, because it helps the brain regulate emotional reactions, making it easier to tolerate and learn from social fears.

The fear of social judgment or rejection are chemicals reacting to outside stimuli, simple.

Inceliety impacted me greatly because of the way incels are judged by society. The powers that be have even orchestrated false flags blaming incel patsies!

Long term Gingko (400-500mg under tongue) with G. Kola has significantly helped ease the pain of inceliety and helped extinguish fear.

Now I live in solitude and return to society whenever I like without the terrible dread like an icepick to the head.

 

[endoftheskies]

Certain endogenous opioids play a significant role in social status, well-being, and fear extinction. Usually people who harbor neurotypical behaviors have a higher social status than those who do not. Here's why:

Endogenous opioids—endorphins and enkephalins—increase social bonding, feeling of reward, and are released during positive social interactions (e.g., hugging, bonding, trust-building).

Negative social interactions create negative feedback loops—incels are mightily susceptible, and not entirely of their own doing—which increase stress, avoidance, anxiety and fear.

There is a direct correlation between higher social status and natural opioid release, which reinforces behaviors that are beneficial for social cohesion and overall mental health.

When neurotypicals contend that incels are better off living alone and sexless because "life is more than just sex and community," they forget to mention that human health is derived from positive social interactions and sex, both of which release endogenous opioids while resensitizing the euphoric mu opiod receptors due to positive feedback loops.
When we observe humans living in this realm of existence, it's as if viewing an entirely different species. Neurotypicals appear to behave foreign to incels because their brain chemistry is uniquely different.
Neurotypicals are usually more successful because opioids as regulators of social stress, so with each positive interaction they can more easily climb the social ladder and feel confidant in who they are. A neurotypical can be a sociopath, psychopath, or a stone, cold killer, as long as his/her interactions are positive, and his/her sins stay hidden, society will coddle and uplift.
Avoidance behavior, even sickness syndrome—most of society will abandon you the moment who acquire a chronic illness—decreases endogenous opioid release while amplifying the density of kappa opioid receptors, which, while a reliever of physical pain, causes significant dysphoria, fear, dread and anxiety.
God literally made it so that humans, as social beings, feel a rush of heavenly euphoria from positive social interactions, while incels and shy folks who are marginalized, ostracized, their pain obfuscated by society, are left with a shitty opioid that relieves physical body pain but sends your mind to the looney bin.

The kappa-opioid receptor (KOR) works directly against extinction.

I've tried a synthetic kappa-opioid receptor agonist and all I can say is that if you want to take a drug from Satan, that's your best bet.

Everything about a social interaction is foreign, even if you already have anxiety. You feel derealized, depersonalized, as if looking out of a cave at the world in total dread, feeling terror every time someone speaks a word. A nightmare in hell. This is the full spectrum of emotions a lonely, socially deprived incel will experience by way of total inceliety 'ascension.'

Kappa is activated during stress, SOCIAL DEFEAT, HUMILIATION, and produces dysphoria, withdrawal, freezing, and is overactive in PTSD, Social anxiety, Chronic stress, diseases such as Huntington's, Lupus, and in infectious diseases such as Borreliosis.

So kappa or KOR activation, while it relieves physical pain, strengthens fear memories, increases social avoidance and reduces dopamine. The end result being a double-edged sword that feeds our terror further.
Literally chronic social fear = high KOR tone, low MOR tone. It's not just in your head, it's not psychosomatic, you cannot just "rethink shit and feel better," it's a physical neurotransmitter imbalance due to negative interactions with the outside world.

What's the most common full agonist of the Kappa opioid receptor?
Want to guess?
Salvia. Yes, the herb boomers and Pakis sold to HS kids at gas stations. The worst hallucinogenic plant on the planet that sends you straight to hell. Might this be the universes' way of telling us to not hide away or is it telling us to do the very opposite?
So we've learned that endogenous opioids act as a buffer to social stress, where higher levels buffer the negative emotional effects of social exclusion and social conflict.

So this would suggest opioids, in moderation, help regulate emotional states and reduce the negative emotional impact of fear. Clearly opioids cannot be taken longterm as they desensitize receptors and are addictive.
So what compounds enhance opioid resensitization that would be optimal for long-term fear extinction?
Well, first, how exactly do opioids enhance fear extinction?

They do this by modulating emotional memory during the extinction process—specifically μ-opioid (MOR) receptors in the prefrontal cortex and amygdala, where fear response is most prevalent.
Activation of these receptors reduces the emotional intensity of the fear memory, which helps facilitate the extinction process while promoting neuroplasticity and dopamine release, both of which strengthen new, non-fearful associations. So neurotypicals are always high on life. "Fuck you, YOU're ruining my high, incel!"

In animals, opioid receptor agonists (such as morphine or oxycontin) have been shown to increase extinction learning by reducing the anxiety or distress related to fearful memories, modulating emotional salience—essentially making the exposure to a feared stimulus less aversive, which makes it easier to extinguish the fear response. However, longterm use has the opposite impact.

Fear extinction is not erasing fear, but learning a new “safe” memory that inhibits the old fear memory. Opioid signaling is involved because extinction is emotionally costly for the brain—society tends to ignore this if the sufferer is short or ugly.
In more technical terms, opioid receptors act as an internal emotional pain buffer that permits extinction learning. If distress is too high, extinction fails. If distress is fully numbed, learning also fails. There's an optimal balance that neurodivergents cannot normalize.
μ-opioid receptor (MOR) are most important and are activated by endorphins. MOR literally encodes relief, safety, and social comfort, and are highly expressed in the Amygdala, Prefrontal cortex, Periaqueductal gray (threat modulation) — all critical for fear extinction.
What MOR does is reduce aversive prediction error such as "this is bad", "stay away," "I'm anxious," and does it completely subconsciously. Even if the feelings are legitimate, it's better to feel euphoric and grounded in the face of it all than anxious in the fetal position.

So MOR encodes in the brain that the feared thing happened, but I survived and it wasn’t catastrophic. You see many Staceys, Beckys and Chads on social media spew, "pain is gain," or "you have to put yourself into uncomfortable situations to progress."
Here's the catch. Their fear isn't ours. Our fear is 100 fold, theirs is euphoria and anxious excitement, perhaps a quiver of the gonads, ours is dread, even terror.

We know that blocking MOR (e.g., naloxone) impairs fear extinction considerably, and in animals models rodents will avoid other rodents.

So how can we, as incels with inceliety, embrace our livelihood (this goes for NEETS as well—the most hated of all peoples) and resensitize opioid receptors?
It has been recently discovered that the ancient tree, Gingko biloba, which survived multiple mammalian extinction events, has been found to enhance opioid receptor sensitivity significantly by modulating dopamine and serotonin systems and increasing the reactivity of μ-opioid receptors—the feel good opioid. This could theoretically enhance the effect of opioids on fear extinction. And I believe it has worked for me.

My initial bout with synthetic MOR enhancing opioids occurred after a kidney stone. Upon ingestion of multiple kinds, I had this epiphany that I was anxiety free for once in my life, and talked to two stacey nurses, who were gossiping about other men and women, and one of whom I knew from high school, but I had zero anxiety, and talked to them despite feeling like hell. I didn't care that my life was/is in shambles and theirs mogged mine to oblivion. I didn't stutter, I just lived in the moment despite the existential hilarity of it all.

Multiple studies have found that Gingko improves the function of opioid receptors (μ-opioid receptors in particular), making them more responsive to endogenous opioids. This means greater social reward and better stress regulation from social interactions (both key in emotional regulation).

The catch is that you cannot go buying any old Gingko supplement. 70% of all Gingko supplements are adulterated and not standardized. More than half the brands lie about their constitutes. The supplement industry is full of criminals.

The only Gingko on the market that is tested, standardized and has a significant amount of the chemical in Gingko that enhances fear extinction is from Nootropics Depot.
So synthetic opioids, even natural opioids like Kratom, will certainly work for short term use and strongly enhance extinction learning, even when microdosimg, “overwriting” fearful subconscious memories, but have significant and contradictory long-term risks, including addiction, tolerance, and withdrawal; cognitive learning blockage, emotional blunting and anhedonia are also horrible side effects.
Why not take herbs that raise our natural opioid reponse longterm?

Gingko and Gotu Kola are two options. The latter is a anxiolytic that can improve fear extinction by enhancing prefrontal cortex control over the amygdala. It’s beneficial for people with social anxiety, like me, because it helps the brain regulate emotional reactions, making it easier to tolerate and learn from social fears.
The fear of social judgment or rejection are chemicals reacting to outside stimuli, simple.

Inceliety impacted me greatly because of the way incels are judged by society. The powers that be have even orchestrated false flags blaming incel patsies!
Long term Gingko (400-500mg under tongue) with G. Kola has significantly helped ease the pain of inceliety and helped extinguish fear.

Now I live in solitude and return to society whenever I like without the terrible dread like an icepick to the head.

dont like opoids block signals to your brain by absorbing them? but that also like slows down your heart and stuff like that? also human health is based around friendship, sociality, and understanding + sex is an basic physiological need.

 

[Chud Norris72]

Brutal IQ mog

 

[Lv99_BixNood]

What about addiction?

 

[turbocuckcel_7000]

the idea of creating a "Matrix" with the right cocktail of substances is just repulsive to me. i learned how to cope with going out to like 3-4 useful locations outside, like shops and the mall, and that's good enough for me. you MUST be capable of achieving that without using substances.

 

[MajorThomas666]

What about addiction?

Read the whole thing. Increase your MOR naturally using standardized Gingko and G. kola for longterm use (these plants are good for you), which will significantly help decrease KOR—the dysphoric opioid in people like us, and mute fear memories.

Trust me, it works and not doing anything sucks.

That said, micro-dosing opioids short term is fine, but longterm abuse, any longer than three days, will mute MOR opioid response for social bonding and tilt the tide towards dysphoric KOR.

 

[MajorThomas666]

the idea of creating a "Matrix" with the right cocktail of substances is just repulsive to me. i learned how to cope with going out to like 3-4 useful locations outside, like shops and the mall, and that's good enough for me. you MUST be capable of achieving that without using substances.

There's no matrix. It is proven that isolation and social rejection will increase KOR, further ingraining fear response. It's natural, and markedly similar to sickness syndrome. It's not entirely the fault of the sufferer because social rejection are the biggest contributors of an over amplified KOR and muted dopamine release in social situations.

That said, while it's quite easy going out and buying stuff, socialization with strangers or new people is a different matter entirely.

I've made the case that ostracized, marginalized, and/or chronically ill people, hermitcels as well, will naturally have higher levels of KOR, so while people like you and normies say, "pain is gain," or "just think good thoughts and your anxiety will vanish, you just gotta get out there," fail to understand while they may feel nervous excitement in similar situations, the above mentioned have nots feel dread and terror 100 fold, which manifest in Aspergergic episodes and subconscious flight or flight responses that they cannot control.

Exposure therapy might not work, and might make it worse, ingraining fear response further, so it's good to increase MOR baseline naturally with herbs so that rejection and fear response will be greatly muted.

Then exposure therapy is possible.

If you ever want to feel the amplification of KOR, like I said, take a Kappa Opioid agonist (these are non-addictive for good reason). You will feel like you're in hell. This is how the ostracized and marginalized feel socializing in society.

Go to a party on a Kappa agonist. It's 1000 fold worse than a bad mushroom trip, and you're lucid the whole time.

Why God thought it awesome to give the have nots an amplified KOR response upon social rejection is a mystery. Maybe he's a very nice man trying to protect us from the pain of future social rejection.

All I'm saying is that those who suffer greatly from social anxiety or have a fear of socialization, or perhaps don't but hate it nonetheless; these are all indications of over-exaggerated KOR response, something normies and Chad don't have.

My solution was to increase the feel good opioids naturally and sustainably using healthy non-addictive plants to decrease KOR and fear response, and create the desire to socialize despite social rejection.

 

[Erenincel]

Do you have any research? A need research now. Autistic people have a depressed HPA axis, which amplifies the effect of what you're talking about. So it's quite possible you're right.

 

[Eunuch]

when ur subaltern, psychedelics and dissociatives mog pure endorphin release drugs

 

[MajorThomas666]

Kappa opioid activation changes protein profiles in different regions of the brain relevant to depression

Depression is a widespread disorder with a significant burden on individuals and society. There are various available treatments for patients with dep…

www.sciencedirect.com

Unfortunately KOR binding as it relates to neurodivergence is not well studied.

 

[Erenincel]

Unfortunately KOR binding as it relates to neurodivergence is not well studied.

Ok this the theory. at least we know where to look for the source of our problem. especially since certain neurobiological differences have already been discredited and autism changes its treatment to anxiety stimuli. Do you have any research on this? Although research indicates that this may be the case?

 

[Erenincel]

when ur subaltern, psychedelics and dissociatives mog pure endorphin release drugs

We need a more research. but normies are not interested in how the autistic brain works because it is not important to them

 

[Erenincel]

Unfortunately KOR binding as it relates to neurodivergence is not well studied.

I know that benzodiazepines work for me and they are related to the same neurological stress system. it means we know where to look for the cause.The reason lies in biological neurological differences that make autistic people suffer more. Is there any research on this?

 

[VanGobbel]

chatgptcels.is

 

[ForcedMarriageNow]

Everything about a social interaction is foreign, even if you already have anxiety. You feel derealized, depersonalized, as if looking out of a cave at the world in total dread, feeling terror every time someone speaks a word. A nightmare in hell.

That just sounds like my usual experience in social situations honestly. I guess that's what happens when I have a lifetime of negative social experiences with basically nothing to counter balance.

 

[EcstasyCel]

BPD chicks and autistic guys should start making love to each other and heal their traumas. But soyciety will use lies and threats to prevent it from happening, fucking scum.

 

[MajorThomas666]

I know that benzodiazepines work for me and they are related to the same neurological stress system. it means we know where to look for the cause.The reason lies in biological neurological differences that make autistic people suffer more. Is there any research on this?

The thing is... there's not a one size fits all. You target one neurotransmitter, that will impact another. My theory above concerns neurodivergence as it relates to external factors, eg. repeated negative interactions, which desensitizes MOR and enhances KOR. That isn't to say these are the only neurotransmitters affected, there's a downstream and upstream impact as well.

You say GABA agonists help. They are chief inhibitory compounds, so they can mute glutamate excitation of NMDA rectors, but they, as you say, are not the sole cause for neuroinflamation or neurological differences between autistic and control.

For example, GABA antagonists, things that block GABA, actually help my Asperger's tremendously, whereas GABA agonists increase cognitive problems, and reduce my concentration greatly.

My belief is that Autism and Aspergers have two things in common. They likely have overemphasized KOR, particularly if social interactions are anxiety inducing. So external stressors contribute.

But there's also likely a disequilibrium at the L-Tryptophan/Kynurenine pathway, oxidized by indoleamine 2,3-dioxygenase (IDO), where. L-Tryptophan either converts to 5HTP and downstream melatonin and serotonin, or to L-Kynurenine, which downstream lies Kynurenic acic, QUIN, etc.

Does the kynurenine pathway play a pathogenic role in autism spectrum disorder?

Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by deficits in communication, sociability, and repetitive/stereotyped be…

www.sciencedirect.com

Many studies performed on schizophrenia patients with neuroinflammation have shown elevated kynurenic acid (KA) levels. Autism patients also have elevated KA. Why? My belief is that kynurenic acid is neuroprotective but increases cognitive deficits due to its strong NMDA antagonism. NMDA is needed for memory, wakefulness and is associated with processing information. Muting NMDA can decrease cognitive ability, but NMDA agonists like QUIN, downstream of Kynurenic acid, are extrnenly neuro/excitotoxic, and cause cell death. QUIN is utilized by astrocytes and microglia to destroy foreign things, such as infections in the brain, as well as to produce NAD+—a cofactor in cellular respiration and energy production that plays an important role in the DNA repair and transcriptional regulation. It's a glutamatergic excitotoxin that can cause brain lesions which is produced in answer to inflammation via cytokine cascade as a way to increase these NAD+ levels so to provide more energy to the cell. So clearly something is happening upstream, a root etiology that causes these neurodegenerative problems.

The production of QUIN occurs at a much faster rate within the brain than the conversion to NAD+. This has implications for the accumulation and destruction of NMDA, which can lead to neuronal death and severe cognitive dysfunction. My belief is that anti-NMDA receptor encephalitis occurs because of over-firing of NMDA receptors by QUIN, a potent NMDA receptor agonist, much stronger than ammonia or MSG, which leads to over-excitation and neuronal death.

In rare cases, the body, which always tries to find an equilibrium, sees no choice but to target and eliminate NMDA receptors, which leads to the terrible pathology mentioned. It is very likely chronic stealth viral, bacterial, parasite brain infections are contributors or even etiologies of ASD, if not genetic.

It has also been reported in recent years that kynurenic acid may play a role in inflammatory neurological and behavioral disorders. High levels of kynurenic acid, which work against NMDA, exist in patients with impaired cognitive function. Cognitive disorders, which may be associated with the glutamatergic system, are very common problems in ASD. Again, I think elevated KA is a way to block overexcitation of NMDA by QUIN, which would imply either brain infection or stressor that causes neuronal death at NMDA.

"...whereas QUIN serum concentration was significantly increased in the ASD patient group."


Source: https://pmc.ncbi.nlm.nih.gov/articles/PMC7563403/

"Genetic analyses revealed tryptophan 2,3-dioxygenase polymorphism in autism [151]. Likewise, tryptophan 5-hydroxylase (THP) gene polymorphism has been clearly associated with autism and other neurological disorders [152], Cascio et al. [153] detected, in the ASD population, pathogenic variants in the genes encoding the heavy (SLC3A2) and light subunits (SLC7A5 and SLC7A8) of the large amino acid transporters (LAT) 1 and 2. LAT1 and 2 are responsible for the transportation of tryptophan and other large aromatic amino acids across the blood–brain barrier and are expressed both in blood and brain. Such abnormalities could affect tryptophan availability during brain development, indirectly altering serotonin and KP activity. Furthermore, the tryptophan metabolism-related enzyme quinolinate phosphoribosyl-transferase (QPRT) affects the regulation of genes and gene networks previously implicated in ASDs [154] and, at the same time, a deletion in 16p11.2, the chromosomal regions responsible for QPRT codification, has strongly been associated to ASD [154].

"Of no less importance, ASD-associated genetic variations are found in genes coding for NMDAr subunits [155], on which kynurenine neuroactivity is carried out.

"This evidence suggests a link between neuro-inflammation, ASD and kynurenines. Since kynurenines may act directly and indirectly on different neurotransmitter systems, and in turn, are influenced by some environmental conditions such as infection, stress, and inflammation, it can be assumed that kynurenines may play a key role in ASD etiology."

From everything I've researched, Gingko (Bilabolide, kaempferol) and Harmine (be very careful with this stuff; NGF +, cannot take with certain foods) have had the most potent impact at nearly eliminating Aspergers symptoms.

Or if you must, Gingko and tetrahydroharmine, which doesn't have strong MAOI (RIMA), but acts as a SSRI and NGF+.

What Gingko and its alkaloids do is increase GABA longterm by antagonizing it, while modulating glutamate. This increases baseline of inhibitory GABA and baseline of Dopamine. Gingko also repairs MOR and lowers KOR longterm. THH increases serotonin and helps with the conversion of serotonin.

It's the best combo I've found.

There are of course other ways to do things, bur ASD is most probably genetic, I just think the genetic distortion occurs around this pathway.

 

[MajorThomas666]

I know that benzodiazepines work for me and they are related to the same neurological stress system. it means we know where to look for the cause.The reason lies in biological neurological differences that make autistic people suffer more. Is there any research on this?

So you're right. If QUIN is seen elevated in ASD, and QUIN overexcites NMDA, an excitatory neurotransmitter, then taking things that increase GABA would help to reduce the over-excitation indirectly, and lead to reduced symptoms.

You could take NMDA antagonists to see how you feel. Chelated magnesium derivatives, magnesium glycinate or magnesium taurate, etc, are endogenous physiological NMDA antagonists, though they modulate this process and do not block NMDA fully. There's also low dose ketamine, but that's a last resort. Ketamine is a full blown NMDA antagonist.

Zinc blocks NR2A subunits at NMDA receptors.

I feel cognitively impaired taking NMDA antagonists of any kind.

Taurine, curcumim, resveratrol, EPA/DHA, and Gingko, which I personally advocate for—

• Flavonoids (Quercetin) reduce/modulate glutamate release, indirectly (glutamate is a NMDA agonist); Protects dopaminergic neurons; Mild MAO inhibition (very weak, indirect), so slightly increase in serotonin. Indirect NMDA modulation: Reduces oxidative stress downstream of NMDA activation
• Kaempferol: reduced glutamate over-excitation; Anti-inflammatory protection of dopamine pathways, increases blood flow to brain
• Terpenes inhibit NMDA-mediated excitotoxic pathways
• Antioxidant protection of NMDA-regulated neurons
• Gingkolides: BAD THING (depending on how you see it) = Platelet-Activating Factor (PAF) inhibitors. GOOD THING = lowers calcium signaling overload (glutamate reduction)
  • GABA
    • Mild stabilizing modulation
  • Acetylcholine
    • Improves signaling efficiency (memory-related)
  • Dopamine
    • Indirect protection of dopaminergic neurons

If you can find Gingko standardized to Kaempferol and Bilobalide, that's your best bet. Harmine and Tetrahydroharmine (THH) impact EAAT2 and can greatly reduce glutmata overexcitation. Both, but especially Gingko, produce this calm, non-anxious alertness.

And as for GABA, what I love about Gingko, is that the Terpene Bilobalide modulates GABA channel kinetICs, that is, desensitization and recovery. Hence, stabilization of receptor function under stress, which is far more important that GABA agonists that ha e addiction and withdrawal potential.

 

[Erenincel]

This is good theory.

So you're right. If QUIN is seen elevated in ASD, and QUIN overexcites NMDA, an excitatory neurotransmitter, then taking things that increase GABA would help to reduce the over-excitation indirectly, and lead to reduced symptoms.

You could take NMDA antagonists to see how you feel. Chelated magnesium derivatives, magnesium glycinate or magnesium taurate, etc, are endogenous physiological NMDA antagonists, though they modulate this process and do not block NMDA fully. There's also low dose ketamine, but that's a last resort. Ketamine is a full blown NMDA antagonist.

Zinc blocks NR2A subunits at NMDA receptors.

I feel cognitively impaired taking NMDA antagonists of any kind.

Taurine, curcumim, resveratrol, EPA/DHA, and Gingko, which I personally advocate for—

• Flavonoids (Quercetin) reduce/modulate glutamate release, indirectly (glutamate is a NMDA agonist); Protects dopaminergic neurons; Mild MAO inhibition (very weak, indirect), so slightly increase in serotonin. Indirect NMDA modulation: Reduces oxidative stress downstream of NMDA activation
• Kaempferol: reduced glutamate over-excitation; Anti-inflammatory protection of dopamine pathways, increases blood flow to brain
• Terpenes inhibit NMDA-mediated excitotoxic pathways
• Antioxidant protection of NMDA-regulated neurons
• Gingkolides: BAD THING (depending on how you see it) = Platelet-Activating Factor (PAF) inhibitors. GOOD THING = lowers calcium signaling overload (glutamate reduction)
  • GABA
    • Mild stabilizing modulation
  • Acetylcholine
    • Improves signaling efficiency (memory-related)
  • Dopamine
    • Indirect protection of dopaminergic neurons

If you can find Gingko standardized to Kaempferol and Bilobalide, that's your best bet. Harmine and Tetrahydroharmine (THH) impact EAAT2 and can greatly reduce glutmata overexcitation. Both, but especially Gingko, produce this calm, non-anxious alertness.

And as for GABA, what I love about Gingko, is that the Terpene Bilobalide modulates GABA channel kinetICs, that is, desensitization and recovery. Hence, stabilization of receptor function under stress, which is far more important that GABA agonists that ha e addiction and withdrawal potential.

This is good theory. I try this maybe this work. It's just a pity that there are no studies on the impact of this, and research on autism shows that there are different paths to these symptoms.

 

[proudweeb]

I tried kratom and i just absolutely spewed puke everywhere

 

[VanGobbel]

RIP @MajorThomas666

 

[BasedGoyslopReviews]

told u this guy is iq mogger
gonna read every single word later

 

[KetamineCel]

was the KOR drug you referenced Salvinorin A? or something similar

 

[MajorThomas666]

was the KOR drug you referenced Salvinorin A? or something similar

Yes, and a synthetic drug I paid 180 dollars just to try. You can find it on wiki's KOR page. It doesn't cause hallucinations like Salvia, but it does make me feel like if I got rejected by multiple women and then made fun of, that feeling, but constant and sustained with derealized dread.

Incels are in a constant state of pseudo-opioid withdrawal.

 

[KetamineCel]

Yes, and a synthetic drug I paid 180 dollars just to try. You can find it on wiki's KOR page. It doesn't cause hallucinations like Salvia, but it does make me feel like if I got rejected by multiple women and then made fun of, that feeling, but constant and sustained with derealized dread.

Incels are in a constant state of pseudo-opioid withdrawal.

insightful tbh, i want to source heroin but it’s basically wiped out all over europe after the taliban crackdown

 

[trrrrrsarescary]

Would microdosing salvia frequently desensitize this hyperactive KOR system?

Also could this hypersensitive KOR be the reason I feel such an intense surge of burning murderous hatred after I get stared at judgmentally by someone irl? It's such an instantaneous attack of rage equivalent to 5 men whos daughters got raped, and I get stared at a lot irl so these surges happen almost every time I go out, I always cycle home from the gym having the most fucking excruciatingly rageful thoughts towards these people staring at me, just one stare can ruin my day completely

 

[Lonelyus]

I had oxycontin once, It made me feel happy and normal.

 

[Balding Subhuman]

Makes sense. I've always loved opioids, and they definitely made me more social. The relief they give me is insane, but I've been trying to live my life without them. My understanding is also the same as yours, trauma can likely cause these receptors to not function in their intended way. Trauma leaves a lasting print on your brain that might be even impossible to heal fully.

I've also tried ginkgo and as you said, it didn't work, likely because the brand was just bad. Meditation and exercise can also trigger the release of endorphins, they have helped me a bit.

 

[Extern]

Kappa is activated during stress, SOCIAL DEFEAT, HUMILIATION, and produces dysphoria, withdrawal, freezing, and is overactive in PTSD, Social anxiety, Chronic stress, diseases such as Huntington's, Lupus, and in infectious diseases such as Borreliosis—the highest suicide rats among all diseases.

So kappa or KOR activation, while it relieves physical pain, strengthens fear memories, increases social avoidance and reduces dopamine. The end result being a double-edged sword that feeds our terror further.
Literally chronic social fear = high KOR tone, low MOR tone. It's not just in your head, it's not psychosomatic, you cannot just "rethink shit and feel better," it's a physical neurotransmitter imbalance due to negative interactions with the outside world.

What's the most common full agonist of the Kappa opioid receptor?

Want to guess?

Salvia. Yes, the herb boomers and Pakis sold to HS kids at gas stations. The worst hallucinogenic plant on the planet that sends you straight to hell.

Fascinating. I did not know.

I've tried a few opioids, I think the only one worth doing is kratom powder

 

[Dx_oxor02]

Certain endogenous opioids play a significant role in social status, well-being, and fear extinction. Usually people who harbor neurotypical behaviors have a higher social status than those who do not. Here's why:

Endogenous opioids—endorphins and enkephalins—increase social bonding, feeling of reward, and are released during positive social interactions (e.g., hugging, bonding, trust-building).

Negative social interactions create negative feedback loops—incels are mightily susceptible, and not entirely of their own doing—which increase stress, avoidance, anxiety and fear.

There is a direct correlation between higher social status and natural opioid release, which reinforces behaviors that are beneficial for social cohesion and overall mental health.

When neurotypicals contend that incels are better off living alone and sexless because "life is more than just sex and community," they forget to mention that human health is derived from positive social interactions and sex, both of which release endogenous opioids while resensitizing the euphoric mu opiod receptors due to positive feedback loops.

When we observe humans living in this realm of existence, it's as if viewing an entirely different species. Neurotypicals appear to behave foreign to incels because their brain chemistry is uniquely different.

Neurotypicals are usually more successful because opioids as regulators of social stress, so with each positive interaction they can more easily climb the social ladder and feel confidant in who they are.

A neurotypical can be a sociopath, psychopath, or a stone, cold killer, as long as his/her interactions are positive, and his/her sins stay hidden, society will coddle and uplift.

Avoidance behavior, even sickness syndrome—most of society will abandon you the moment who acquire a chronic illness—decreases endogenous opioid release while amplifying the density of kappa opioid receptors, which, while a reliever of physical pain, causes significant dysphoria, fear, dread and anxiety.

God literally made it so that humans, as social beings, feel a rush of heavenly euphoria from positive social interactions, while incels and shy folks who are marginalized, ostracized, their pain obfuscated by society, are left with a shitty opioid that relieves physical body pain but sends your mind to the looney bin.

The kappa-opioid receptor (KOR) works directly against extinction.

I've tried a synthetic kappa-opioid receptor agonist and all I can say is that if you want to take a drug from Satan, that's your best bet.

Everything about a social interaction is foreign, even if you already have anxiety. You feel derealized, depersonalized, as if looking out of a cave at the world in total dread, feeling terror every time someone speaks a word. A nightmare in hell. This is the full spectrum of emotions a lonely, socially deprived incel will experience by way of total inceliety 'ascension.'

Kappa is activated during stress, SOCIAL DEFEAT, HUMILIATION, and produces dysphoria, withdrawal, freezing, and is overactive in PTSD, Social anxiety, Chronic stress, diseases such as Huntington's, Lupus, and in infectious diseases such as Borreliosis—the highest suicide rats among all diseases.

So kappa or KOR activation, while it relieves physical pain, strengthens fear memories, increases social avoidance and reduces dopamine. The end result being a double-edged sword that feeds our terror further.
Literally chronic social fear = high KOR tone, low MOR tone. It's not just in your head, it's not psychosomatic, you cannot just "rethink shit and feel better," it's a physical neurotransmitter imbalance due to negative interactions with the outside world.

What's the most common full agonist of the Kappa opioid receptor?

Want to guess?

Salvia. Yes, the herb boomers and Pakis sold to HS kids at gas stations. The worst hallucinogenic plant on the planet that sends you straight to hell.

Might this be the universes' way of telling us to not hide away or is it telling us to do the very opposite?

So we've learned that endogenous opioids act as a buffer to social stress, where higher levels buffer the negative emotional effects of social exclusion and social conflict.

So this would suggest opioids, in moderation, help regulate emotional states and reduce the negative emotional impact of fear. Clearly opioids cannot be taken longterm as they desensitize receptors and are addictive.

So what compounds enhance opioid resensitization that would be optimal for long-term fear extinction?

Well, first, how exactly do opioids enhance fear extinction?

They do this by modulating emotional memory during the extinction process—specifically μ-opioid (MOR) receptors in the prefrontal cortex and amygdala, where fear response is most prevalent.

Activation of these receptors reduces the emotional intensity of the fear memory, which helps facilitate the extinction process while promoting neuroplasticity and dopamine release, both of which strengthen new, non-fearful associations. So neurotypicals are always high on life. "Fuck you, YOU're ruining my high, incel!"

In animals, opioid receptor agonists (such as morphine or oxycontin) have been shown to increase extinction learning by reducing the anxiety or distress related to fearful memories, modulating emotional salience—essentially making the exposure to a feared stimulus less aversive, which makes it easier to extinguish the fear response. However, longterm use has the opposite impact.

Fear extinction is not erasing fear, but learning a new “safe” memory that inhibits the old fear memory. Opioid signaling is involved because extinction is emotionally costly for the brain—society tends to ignore this if the sufferer is short or ugly.

In more technical terms, opioid receptors act as an internal emotional pain buffer that permits extinction learning. If distress is too high, extinction fails. If distress is fully numbed, learning also fails. There's an optimal balance that neurodivergents cannot normalize.
μ-opioid receptor (MOR) are most important and are activated by endorphins. MOR literally encodes relief, safety, and social comfort, and are highly expressed in the Amygdala, Prefrontal cortex, Periaqueductal gray (threat modulation) — all critical for fear extinction.

What MOR does is reduce aversive prediction error such as "this is bad", "stay away," "I'm anxious," and does it completely subconsciously. Even if the feelings are legitimate, it's better to feel euphoric and grounded in the face of it all than anxious in the fetal position.

So MOR encodes in the brain that the feared thing happened, but I survived and it wasn’t catastrophic. You see many Staceys, Beckys and Chads on social media spew, "pain is gain," or "you have to put yourself into uncomfortable situations to progress."

Here's the catch. Their fear isn't ours. Our fear is 100 fold, theirs is euphoria and anxious excitement, perhaps a quiver of the gonads, ours is dread, even terror.

We know that blocking MOR (e.g., naloxone) impairs fear extinction considerably, and in animals models rodents will avoid other rodents.

So how can we, as incels with inceliety, embrace our livelihood (this goes for NEETS as well—the most hated of all peoples) and resensitize opioid receptors?

It has been recently discovered that the ancient tree, Gingko biloba, which survived multiple mammalian extinction events, has been found to enhance opioid receptor sensitivity significantly by modulating dopamine and serotonin systems and increasing the reactivity of μ-opioid receptors—the feel good opioid. This could theoretically enhance the effect of opioids on fear extinction. And I believe it has worked for me.

My initial bout with synthetic MOR enhancing opioids occurred after a kidney stone. Upon ingestion of multiple kinds, I had this epiphany that I was anxiety free for once in my life, and talked to two stacey nurses, who were gossiping about other men and women, and one of whom I knew from high school, but I had zero anxiety, and talked to them despite feeling like hell. I didn't care that my life was/is in shambles and theirs mogged mine to oblivion. I didn't stutter, I just lived in the moment despite the existential hilarity of it all.

Multiple studies have found that Gingko improves the function of opioid receptors (μ-opioid receptors in particular), making them more responsive to endogenous opioids. This means greater social reward and better stress regulation from social interactions (both key in emotional regulation).

The catch is that you cannot go buying any old Gingko supplement. 70% of all Gingko supplements are adulterated and not standardized. More than half the brands lie about their constitutes. The supplement industry is full of criminals.

The only Gingko on the market that is tested, standardized and has a significant amount of the chemical in Gingko that enhances fear extinction is from Nootropics Depot.

So synthetic opioids, even natural opioids like Kratom, will certainly work for short term use and strongly enhance extinction learning, even when microdosimg, “overwriting” fearful subconscious memories, but have significant and contradictory long-term risks, including addiction, tolerance, and withdrawal; cognitive learning blockage, emotional blunting and anhedonia are also horrible side effects.

Why not take herbs that raise our natural opioid reponse longterm?

Gingko and Gotu Kola are two options. The latter is a anxiolytic that can improve fear extinction by enhancing prefrontal cortex control over the amygdala. It’s beneficial for people with social anxiety, like me, because it helps the brain regulate emotional reactions, making it easier to tolerate and learn from social fears.

The fear of social judgment or rejection are chemicals reacting to outside stimuli, simple.

Inceliety impacted me greatly because of the way incels are judged by society. The powers that be have even orchestrated false flags blaming incel patsies!

Long term Gingko (400-500mg under tongue) with G. Kola has significantly helped ease the pain of inceliety and helped extinguish fear.

Now I live in solitude and return to society whenever I like without the terrible dread like an icepick to the head.

im not reading all of this but i would love to have a infinite supply of south east asian heroin that appears in australian markets, makes me wet ahhh hellll