Researchers performed genome-wide association studies of standardised national English, maths and science tests using data from the UK-based Avon Longitudinal Study of Parents and Children (ALSPAC) to assess whether there exist academic subject-specific molecular genetic contributions. The performance in the three academic subjects were assessed using National Curriculum-based Standardized Assessment tests (SATs) at 11 and 14 years of age. The academic attainment scores for English (N = 5983), math (N = 6017) and science (N = 6089) were calculated by summing age- and sex-regressed SAT scores from these two time points for each academic subject. After the genotyping, one genome-wide significant single nucleotide polymorphism (SNP) was identified for attainment in science, but none for attainment in English or math. Further 26 independent SNPs showed suggestive evidence of association with science, 38 for math and 16 for English. Rs11264236 in the Natriuretic Peptide Receptor 1 (NPR1) gene and rs10905791 in the Ankyrin Repeat And SOCS Box Containing 13 (ASB13) gene showed suggestive evidence of association with science. The A allele of rs11264236 and the T allele of rs10905791 showed tendencies to increase academic scores in science. In addition, phenotypic correlation analysis revealed that science was significantly more correlated with English and maths than these were with each other.