I think there are few stuff:
You're no longer that young man people despise solely because of his appearance, you’re starting to be seen as true waste. The ''potential of youth'' , which used to make people hold back when silently predicting your future compared to theirs, is gone.
You’re beginning to feel the first effects of aging, even baldness for some.
You notice your sexual needs have slightly diminished (though not the frustration), but the need for love remains and mainly increased.
Years of isolation and depression have deeply affected your entire being, even your body.
Rage gives way to melancholy, and you sigh more than you scream.
The horizon of possibilities has drastically narrowed, and among the few remaining options, suicide often seems the most satisfying.
A small positive point : facing your destiny might give you a final boost to try one last time, hoping for a stroke of luck before ultimately sinking into suicide or the madness of a loveless, enslaved life.