It's Over Just Be Neurotypical!

[Zer0/∞]

View: https://youtu.be/dlIIoXfGQ28
If you don’t have a extroverted, very open normie personality, it’s over! @Transcended Trucel

 

[InMinecraft]

over

 

[kretschmer]

if your born even 1% autistic your a weirdo forever. it the neuro equivalent of the 1 one drop rule.

 

[Transcended Trucel]

if your born even 1% autistic your a weirdo forever. it the neuro equivalent of the 1 one drop rule.

sadly the truth

View: https://youtu.be/dlIIoXfGQ28
If you don’t have a extroverted, very open normie personality, it’s over! @Transcended Trucel

Yup, for any non Chad/rich/high status, only being NT can save them. And it can still get em a looksmatched bitch

 

[sirwolfgang]

Oofy Doofy is brutal AF

 

[HighTGymcel]

Autism = worse than being physically retarded

 

[ionlycopenow]

It’s over

 

[Intellau_Celistic]

if your born even 1% autistic your a weirdo forever. it the neuro equivalent of the 1 one drop rule.

Yes...

Sensorimotor gating is the process by which one filters out relevant from irrelevant information, a process that is deficient in multiple neuropsychiatric disorders including TS (Castellanos et al., 1996). Prepulse inhibition (PPI) is a measure of sensorimotor gating, in which response, or startle, to a stimulus (pulse) is diminished when the stimulus is preceded by a smaller stimulus (prepulse) (Swerdlow, 2013; Swerdlow and Sutherland, 2005). Disruption of this normal inhibition of startle is consistent with deficient sensorimotor gating. Structures relevant to PPI include the frontal dopaminergic pathways and striatum (Swerdlow et al., 2001). Pharmacological interventions that restore normal PPI typically have good predictive validity for efficacy in multiple neuropsychiatric disorders including TS

https://www.sciencedirect.com/topics/medicine-and-dentistry/sensory-gating

Results: Tcf4 transgenic mice display profound deficits in contextual and cued fear conditioning and sensorimotor gating. Furthermore, we show that TCF4 interacts with the neurogenic bHLH factors NEUROD and NDRF in vivo. Molecular analyses revealed the dynamic circadian deregulation of neuronal bHLH factors in the adult hippocampus.

Conclusions: We conclude that TCF4 likely acts in concert with other neuronal bHLH transcription factors contributing to higher-order cognitive processing. Moderate transcriptional deregulation of Tcf4 in the brain interferes with cognitive functions and might alter circadian processes in mice. These observations provide insight for the first time into the physiological function of TCF4 in the adult brain and its possible contributions to neuropsychiatric disease conditions.

Cognitive and sensorimotor gating impairments in transgenic mice overexpressing the schizophrenia susceptibility gene Tcf4 in the brain - PubMed

We conclude that TCF4 likely acts in concert with other neuronal bHLH transcription factors contributing to higher-order cognitive processing. Moderate transcriptional deregulation of Tcf4 in the brain interferes with cognitive functions and might alter circadian processes in mice. These...

pubmed.ncbi.nlm.nih.gov