Remaincel
If you can't reflect god you're not human
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- Joined
- Mar 1, 2021
- Posts
- 7,062
I think this forum is easier to find autistic people than some kind of autistic support organization
I got diagnosed as a childmost people here are self diagnosed autist
I think this forum is easier to find autistic people than some kind of autistic support organization
how can they fix thatNo. It's just that degenerate zoomers made being mentally ill a trend and now every retard and his mother claim to be autistic when in reality they're just dumb.
The Psychiatric Risk Gene Transcription Factor 4 (TCF4) Regulates Neurodevelopmental Pathways Associated With Schizophrenia, Autism, and Intellectual Disability
Genetic variants in and around the transcription factor 4 (TCF4) gene are associated with range of disorders that are frequently associated with cognitive dysfunction.1–3 The most recent schizophrenia GWAS reported three independent single nucleotide polymorphisms (SNPs) in TCF4 that surpassed the threshold for genome wide significance.4 Intriguingly, rare TCF4 single nucleotide variants (SNVs) have also been described in schizophrenia patients, although their impact on the function of the protein has not been established.5,6 In addition to the genetic studies in schizophrenia, TCF4 variants are associated with early information processing and cognitive markers, some of which are schizophrenia endophenotypes.7–10 Damaging TCF4 mutations have also been described in large-scale genotyping studies in patients with ID, neurodevelopmental disorders, and most recently ASD.11–15 Haploinsufficiency of TCF4 causes Pitt–Hopkins syndrome (PTHS); a rare form intellectual disability (ID) associated with characteristic facial features, autonomic dysfunction, and behavioral traits that resemble autism spectrum disorder (ASD).16–19 Collectively, these studies implicate TCF4 in a range of neurodevelopmental disorders.
TCF4 is a member of the basic helix-loop-helix (bHLH) family of proteins.20–22 For the purposes of disambiguation, it should be noted that TCF4 (Gene ID: 6925) described herein should not be confused with T-cell factor 4 (Gene ID: 6934, official gene symbol, TCF7L2) since they can share the same acronym. TCF4 and its paralogues, collectively known as E-proteins, interact with other bHLH proteins to regulate DNA binding specificity and transcriptional activity at promoters and enhancers that contain E-boxes (5′-CANNTG).2,20,23 The human TCF4 gene encodes multiple protein isoforms of which only the major isoforms TCF4-A and TCF4-B have been characterized in detail.24 In neurons, TCF4 regulates the intrinsic excitability of pyramidal cells of the prefrontal cortex and has been shown to attenuate neurite branching.25,26 Furthermore, haploinsufficiency of Tcf4 in mice affects gene expression and DNA methylation in the brain, leading to enhanced long-term potentiation, learning and memory deficits, and autistic-like behavior.22,25,26 By contrast, mice over-expressing Tcf4 in the brain display deficits in sensorimotor gating, fear conditioning, and circadian processes as well as impairments in attentional and behavioral anticipation.7,27
Although the function of TCF4 as transcription factor has been well established, very little is known about the genes regulated by TCF4 in neuronal cells and specifically in cells of human origin. Therefore, to gain a functional insight into the role of TCF4 in schizophrenia other neurodevelopmental disorders, we used a bespoke TCF4 antibody for chromatin immunoprecipitation and next generation sequencing (ChIP-seq) to define the genomic targets of TCF4. We found that TCF4 target genes cluster in neurodevelopmental pathways and are enriched for schizophrenia, ASD, and ID risk genes.
Fix what? Being dumb?how can they fix that
yesFix what? Being dumb?
If you are low IQ and socially maladjusted (meaning you don't recognize social ques or common courtesy) your functionally autistic, autism is the most bland of the treny mental illness all the zoomers are on CPTSD and body dismorphia and shietNo. It's just that degenerate zoomers made being mentally ill a trend and now every retard and his mother claim to be autistic when in reality they're just dumb.
Don't insult autistic people comparing them with those creaturesThe highest incidence of autism is on R/IncelTear.
Read books, educate yourself, self-reflect, think before you say or do something, idk
I get what you're trying to say but if you're just a bit stupid and socially maladjusted there are ways of fixing that, whereas if you have an actual mental illness, it's much harder if not impossible.If you are low IQ and socially maladjusted (meaning you don't recognize social ques or common courtesy) your functionally autistic, autism is the most bland of the treny mental illness all the zoomers are on CPTSD and body dismorphia and shiet
I think this forum is easier to find autistic people than some kind of autistic support organization
It's fixing able when you are younger and have people willing to put in the effort but if anyone on here had that they wouldn't be on this website on the first place. By the time you are in your mid twenties behaviors are really hard to change, soyciety is less patient with trying to teach and you are less likely to meet people willing to humor you and help you improveI get what you're trying to say but if you're just a bit stupid and socially maladjusted there are ways of fixing that, whereas if you have an actual mental illness, it's much harder if not impossible.
Don't insult autistic people comparing them with those creatures





