Video games with female protagonists... I almost never play. If a game has a female protagonist, 95% of the time that's a deal-breaker for me.
It's not that I hate women. It's that a) I'm tired of every game having a female lead and b) I'm a guy so I tend to prefer when the character I'm playing is also a guy.
It's odd because in the past it didn't bother me as much. For example Perfect Dark is one of my favourite games ever made, and I've completed Tomb Raider Legend. It was pretty good! I think though when it didn't feel forced into games, it was less common and it also made more sense within that particular game.
Movies and stuff it bothers me less.