For addictioncels

[Balding Subhuman]

NAC:

Effectiveness of N-acetylcysteine in Treating Clinical Symptoms of Substance Abuse and Dependence: A Meta-analysis of Randomized Controlled Trials - PMC

Treatment with N-acetylcysteine (NAC) is believed to reduce the clinical symptoms among individuals with substance abuse or dependence. We conducted a meta-analysis of randomized controlled trials to evaluate the effectiveness of NAC in treating ...

pmc.ncbi.nlm.nih.gov

Effectiveness of N-acetylcysteine in Treating Clinical Symptoms of Substance Abuse and Dependence: A Meta-analysis of Randomized Controlled Trials​

A significant decrease in craving symptoms was observed in the NAC treatment group compared with the control group (SMD, −0.67; 95% confidence interval [CI], −1.21 to 0.21). When withdrawal and depressive symptoms were considered as a single domain, the NAC treatment group demonstrated a significantly higher overall improvement than the control group (SMD, −0.35; 95% CI, −0.64 to −0.06). No between-group differences in term of the OR of adverse events (OR, 1.18; 95% CI, 0.68 to 2.06) and a non-significant trend toward reduction in smoking frequency was observed in the NAC treatment group compared with the control group (WMD, −3.09; 95% CI, −6.50 to 0.32).

Conclusion​

NAC provides certain noticeable benefits in attenuating substance craving and might help alleviate depressive symptoms and withdrawal syndrome.

Magnesium:

Chapter 24 - Magnesium in drug abuse and addiction​

from Section 3 - Involvement of Magnesium in Psychiatric Diseases

Addiction to different substances is considered to be a psychiatric disorder. Magnesium reduces the intensity of addiction to opiates and psychostimulants (cocaine, amphetamine, nicotine, cocaine and others). It also decreases the auto-administration of cocaine and the relapse into cocaine and amphetamine intake, as well as reducing the experimental addiction to morphine, cocaine and other substances in animals. In heroin addicts, alcohol consumers and other drug abusers, the plasma and intracellular magnesium concentration is lower compared to healthy subjects. We consider that one of the mechanisms by which magnesium reduces the consumption of some highly addictive substances is its moderate effect of stimulating the reward system. However, other main mechanisms involved in magnesium's action are the reduction of dopamine and glutamate release at presynaptic terminals in the brain, the decrease of NO synthase activity, the stimulation of GABAergic system activity, the reduction of postsynaptic NMDA receptor activity, and the reduction of some neuromediators released by Ca2+ and acting at calcium channels.

 

[McFlurryCel]

thanks mate