Dextromethorphan is a medication most often used as a cough suppressant in over-the-counter cold and cough medicines. It is sold in syrup, tablet, spray, and lozenge forms. It is in the morphinan class of medications with sedative, dissociative, and stimulant properties.
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Molar mass: 271.4 g/mol
Formula: C18H25NO
Elimination half-life: 2–4 hours (extensive metabolizers); 24 hours (poor metabolizers)
Metabolism: Hepatic (
liver) enzymes: major
CYP2D6, minor
CYP3A4, and minor
CYP3A5
Trade name: Robitussin, Delsym, DM, DexAlone, Duract, others
Excretion: Renal
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