I always shied away from drugs. Partly because they are an expensive habit, but mostly out of fear of building up a tolerance to them so that when I really need them, they won't work.
Never took to cigarettes, either. Turned my stomach each time I tried. I still don't see where the pleasure lies.
My Dad was a vodka man. At the time, I could not see what he got out of it. Like drinking paint thinner. But, looking back, if I had a wife like his, I just might overlook the taste in order to forget how miserable she was making me, even if only for a little while.