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Fish Oil–Derived Fatty Acids in Pregnancy and Wheeze and Asthma in Offspring
Methods: We randomly assigned 736 pregnant women at 24 weeks of gestation to receive 2.4 g of n-3 LCPUFA (fish oil) or placebo (olive oil) per day.
Results: A total of 695 children were included in the trial, and 95.5% completed the 3-year, double-blind follow-up period. The risk of persistent wheeze or asthma in the treatment group was 16.9%, versus 23.7% in the control group (hazard ratio, 0.69; 95% confidence interval [CI], 0.49 to 0.97; P=0.035), corresponding to a relative reduction of 30.7%. Prespecified subgroup analyses suggested that the effect was strongest in the children of women whose blood levels of eicosapentaenoic acid and docosahexaenoic acid were in the lowest third of the trial population at randomization: 17.5% versus 34.1% (hazard ratio, 0.46; 95% CI, 0.25 to 0.83; P=0.011).
https://www.nejm.org/doi/10.1056/NEJMoa1503734?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub 0www.ncbi.nlm.nih.gov
My comments: We sometimes debate good nutrition vs. genetics on here. This study I came across in my research I am doing for cardiovascular disease.
Anyway this is substantial if you look at just the intervention impact.. you take 1,000 kids for the sake of argument. The intervention would reduce by 70 kids, from 237 kids to 169 kids the number who had asthma/wheezing.
Comparing the high vs. low thirds from blood testing it would be even more impactful.. 175 kids versus 341 kids. Of course further studies with more kids and reproducibility and maybe quintiles instead of thirds would give us more information/confirmation. And identify women at outright deficiency and see the impact. Also to test before women even get pregnant high vs. low levels for a whole pregnancy.
Retards are debating racism or economics.. but this is much bigger impact on the quality of life.
