Well, the human brain is an exceptionally complex thing and there are myriad ways it can go awry. Synapses firing improperly, neurotransmitters being absorbed slightly to quickly or just a bit too slowly can wreak havoc. Someone with such an ailment could have Solomon's harem attending to him and the wealth of Mammon at his disposal and still be miserable.
Having said that, I'll agree its both absurd and insulting to brush the legitimate pain of a man suffering because he's considered and unlovable as some sort of psychological illness. It's quite to the contrary. If an ugly man who has never received affection from the opposite sex, entering middle age without having so much as shared a kiss, was ecstatically happy he would be either a saint or a lunatic. If a human being isn't permitted to live as he was intended to, he becomes sick. It's as simple as that, nothing more than an example of the most common of common sense.
Or it should be. The thing of it is, people become very uncomfortable witnessing the pain the repulsive inevitably endure. They certainly have no qualm about laughing at them, as long as they can be portrayed as endearingly awkward clowns. The moment the deformed jester begins to shed tears as he dances for the amusement of the king and his court, well, his antics are no longer quite so much fun.
So those who are faced with an abomination have one of two options. They can work to portray the monster as a devil, the justifiably angry man as a criminal or, in lieu of an actual crime being committed, a potential one. No one cares when a devil screams in agony and no one sheds a tear when a criminal is executed. In fact, such events are occasions for celebration.
The second choice, the one better suited to the more squeamish, is to silence the wails of the things in agony. Dull the minds to the point where they are incapable of feeling anything any longer, bind their tongues with drugs, clap them in shackles and throw them into hospitals where they can be conveniently forgotten. Let their howls be swallowed up by the indifferent ears of therapists who have trained themselves to listen to shrieks and respond with nothing more than placid smiles and nods of the head.
If one of Nature's mistakes can't serve as a clown, the alchemy of the psychiatrists and therapists can do the next best thing and reduce them to insubstantial shadows: bloodless, voiceless and easily forgotten.
