BBC mogs all

[theworstever]

BBC mogs everything, face, height, frame, cumskin, etc.

 

[Intellau_Celistic]

Yes - The Big Black Cranium

The intergenic variant rs7294919 was associated with hippocampal volume (12q24.22; N = 21,151; P = 6.70 × 10−16) and the expression levels of the positional candidate gene TESC in brain tissue. Additionally, rs10784502, located within HMGA2, was associated with intracranial volume (12q14.3; N = 15,782; P = 1.12 × 10−12). We also identified a suggestive association with total brain volume at rs10494373 within DDR2 (1q23.3; N = 6,500; P = 5.81 × 10−7)

The strongest association with intracranial volume was found for rs10784502

'Earlier studies have uncovered risk genes for common diseases, yet it's not always understood how these genes affect the brain,' says Professor Thompson. 'This led our team to screen brain scans worldwide for genes that directly harm or protect the brain.'

The researchers observed subtle shifts in the genetic code of subjects whose images showed smaller brains. The memory centres were also smaller, according to the team. It should be noted that no matter where the subjects hailed from, the same genes affected the brain in similar ways.

'Millions of people carry variations in their DNA that help boost or lower their brains' susceptibility to a vast range of diseases,' the UCLA researcher says. 'Once we identify the gene, we can target it with a drug to reduce the risk of disease. People also can take preventive steps through exercise, diet and mental stimulation to erase the effects of a bad gene.'

The team also found genes that explain individual differences in intelligence, uncovering a variant in a gene called HMGA2 that affected both brain size and intelligence. DNA has four bases: A, C, T and G; subjects whose HMGA2 gene had C instead of T had larger brains and recorded higher results on standardised intelligence quotient (IQ) tests.

Population	Group	Sample Size	Ref Allele	Alt Allele

Population	Group	Sample Size	Ref Allele	Alt Allele
Total	Global	249570	C=0.462279	T=0.537721
European	Sub	218988	C=0.472976	T=0.527024
African	Sub	7884	C=0.5008	T=0.4992
African Others	Sub	290	C=0.510	T=0.490
African American	Sub	7594	C=0.5004	T=0.4996

rs7294919:

An increased number of rs7294919-T risk alleles was associated with decreased hippocampal volume. Hippocampal volume is highly heritable and implicated in many (neuro)psychiatric disorders, such as schizophrenia, bipolar disorder, major depression and Alzheimer’s disease. The hippocampus is a key brain structure for memory formation and stress regulation, brain functions that are strongly implicated in the above mentioned disorders. The identified quantitative trait locus for hippocampal volume may exert its effects by regulating the expression of the nearby TESC gene.1 This previously not very well studied gene is expressed during development and also moderately during adulthood. Its protein product is involved in cell proliferation and differentiation and thus relevant for hippocampal integrity.

Additionally, rs10784502, located within HMGA2, was associated with intracranial volume

The strongest association with intracranial volume was found for rs10784502. Fixed-effects meta-analysis P values are shown in healthy subjects only. (c,d) The effect within each sample contributing to the meta-analysis is shown in forest plots for hippocampal volume (c) and intracranial volume (d). Association data using intracranial volume as a phenotype were not available for the EPIGEN sample. Head size was not controlled for in the CHARGE Consortium association analyses.

drs10784502 is at 12q14.3: position 64,630,077. Effect allele, C; non-effect allele, T.

When the scientists zeroed in on the DNA of people whose images showed smaller brains, they found a consistent relationship between subtle shifts in the genetic code and diminished memory centers. Furthermore, the same genes affected the brain in the same ways in people across diverse populations from Australia, North America and Europe, suggesting new molecular targets for drug development.


“Millions of people carry variations in their DNA that help boost or lower their brains’ susceptibility to a vast range of diseases,” said Thompson. “Once we identify the gene, we can target it with a drug to reduce the risk of disease. People also can take preventive steps through exercise, diet and mental stimulation to erase the effects of a bad gene.”


In an intriguing twist, Project ENIGMA investigators also discovered genes that explain individual differences in intelligence. They found that a variant in a gene called HMGA2 affected brain size as well as a person’s intelligence.


DNA is comprised of four bases: A, C, T and G. People whose HMGA2 gene held a letter “C” instead of “T” on that location of the gene possessed larger brains and scored more highly on standardized IQ tests.

 

[manletogre]

over4JBW copers

white women belong to BBC

 

[theworstever]

over4JBW copers

white women belong to BBC

BBC is the biggest woman fetish itw

 

[currycel⁰]

ic

 

[theworstever]

over4JBW copers

white women belong to BBC

yeah just be a white cuck with a 5x4.7'' ranger down there and pray to allah that your bbcwhore doesn't' jump on the first BBC she meets jfl our cracker race is beyond retarded

 

[Intellau_Celistic]

BBC is the biggest woman fetish itw

We also identified a suggestive association with total brain volume at rs10494373 within DDR2 (1q23.3; N = 6,500; P = 5.81 × 10−7)

ALFA Allele Frequency
The ALFA project provide aggregate allele frequency from dbGaP. More information is available on the project page including descriptions, data access, and terms of use.


Release Version: 20201027095038

Search:

Population	Group	Sample Size	Ref Allele	Alt Allele

Population	Group	Sample Size	Ref Allele	Alt Allele
Total	Global	197560	A=0.923679	C=0.076321
European	Sub	174448	A=0.922739	C=0.077261
African	Sub	7092	A=0.9267	C=0.0733
African Others	Sub	264	A=0.951	C=0.049
African American	Sub	6828	A=0.9257	C=0.0743
Asian	Sub	702	A=0.989	C=0.011
East Asian	Sub	556	A=0.989	C=0.011

 

[Puppeter]

The amount of guys obsessed with big black dicks is astonishing ababahhahahahahahahahahahahah
Faggot

 

[manletogre]

yeah just be a white cuck with a 5x4.7'' ranger down there and pray to allah that your bbcwhore doesn't' jump on the first BBC she meets jfl our cracker race is beyond retarded

how can tiny dicked whitecels cope when their women are all getting Blacked jfl

 

[theworstever]

cope harder cumskin dicklets

 

[theworstever]

how can tiny dicked whitecels cope when their women are all getting Blacked jfl

only cope is the rope

 

[LeFrenchCel]

Water is wet

 

[Lonely4Ever]

All heil the mighty Yakub, Father of mankind

 

[theworstever]

What is the difference between the BWC fetish and BBC fetish? The former is held by a far larger pool of women, along with white males being seen as actual human beings with desired characteristics - a real dating prospect (granted that you meet a certain looks threshold, yes). BBC is a one and done thing - if you have one and have the typical Tyrone phenotype (or are NT enough to be able to attract the attention of the BBC obsessed). It seems white males loves to skirt by the JBW meme (which does hold truth if you meet the requirements - which are not as high as those needed for a BBC male) by pushing this inane idea. Other ethnics are just weird and cannot get BBC out of their minds - must be infuriating for them.

didn't read, stop coping and take the BBCpill

 

[theworstever]

I'm sure you love BBC...

projecting your girlfriend's fetishes onto me wont work buddy boyo

 

[Dokes]

Half the BBC presenters are Niggers

 

[theworstever]

Half the BBC presenters are Niggers

not a coincidence.

 

[Dokes]

not a coincidence.

Niggers are a violent species and they are all troublemakers . Fuck equality all Niggers belong in a cage

 

[TheShingTard]

This is a fetish thread

 

[theworstever]

Niggers are a violent species and they are all troublemakers . Fuck equality all Niggers belong in a cage

That's true; yet the cumskin toilets love them. Cope harder.

 

[Man]

BBC is the biggest woman fetish itw

Lesbian is the biggest woman fetish

 

[Intellau_Celistic]

Niggers are a violent species and they are all troublemakers . Fuck equality all Niggers belong in a cage

You must be a foid.

 

[Dokes]

You must be a foid.

Pardon me Nigger lover ?

 

[Intellau_Celistic]

Yes - The Big Black Cranium

International team uncovers new genes that shape brain size, intelligence

In the world's largest brain study to date, a team of more than 200 scientists from 100 institutions worldwide collaborated to map the human genes that boost or sabotage the brain's resistance to a variety of mental illnesses and Alzheimer's disease.

www.uclahealth.org

International team uncovers new genes that shape brain size, intelligence​

April 15, 2012

In the world's largest brain study to date, a team of more than 200 scientists from 100 institutions worldwide collaborated to map the human genes that boost or sabotage the brain's resistance to a variety of mental illnesses and Alzheimer's disease.



Published April 15 in the advance online edition of the journal Nature Genetics, the study also uncovers new genes that may explain individual differences in brain size and intelligence.



"We searched for two things in this study," said senior author Paul Thompson, professor of neurology at the David Geffen School of Medicine at UCLA and a member of the UCLA Laboratory of Neuro Imaging. "We hunted for genes that increase your risk for a single disease that your children can inherit. We also looked for factors that cause tissue atrophy and reduce brain size, which is a biological marker for disorders like schizophrenia, bipolar disorder, depression, Alzheimer's disease and dementia."



Three years ago, Thompson's lab partnered with geneticists Nick Martin and Margaret Wright at the Queensland Institute for Medical Research in Brisbane, Australia, and with geneticist Barbara Franke of Radboud University Nijmegen Medical Centre in the Netherlands. The four investigators recruited brain-imaging labs around the world to pool their brain scans and genomic data, and Project ENIGMA (Enhancing Neuro Imaging Genetics through Meta-Analysis) was born.



"Our individual centers couldn't review enough brain scans to obtain definitive results," said Thompson, who is also a professor of psychiatry at the Semel Institute for Neuroscience and Human Behavior at UCLA. "By sharing our data with Project ENIGMA, we created a sample large enough to reveal clear patterns in genetic variation and show how these changes physically alter the brain."



In the past, neuroscientists screened the genomes of people suffering from a specific brain disease and combed their DNA to uncover a common variant. In this study, Project ENIGMA researchers measured the size of the brain and its memory centers in thousands of MRI images from 21,151 healthy people while simultaneously screening their DNA.



"Earlier studies have uncovered risk genes for common diseases, yet it's not always understood how these genes affect the brain," Thompson said. "This led our team to screen brain scans worldwide for genes that directly harm or protect the brain."



In poring over the data, Project ENIGMA researchers explored whether any genetic variations correlated to brain size. In particular, the scientists looked for gene variants that deplete brain tissue beyond normal in a healthy person. The sheer scale of the project allowed the team to unearth new genetic variants in people who have bigger brains, as well as differences in regions critical to learning and memory.



When the scientists zeroed in on the DNA of people whose images showed smaller brains, they found a consistent relationship between subtle shifts in the genetic code and diminished memory centers. Furthermore, the same genes affected the brain in the same ways in people across diverse populations from Australia, North America and Europe, suggesting new molecular targets for drug development.



"Millions of people carry variations in their DNA that help boost or lower their brains' susceptibility to a vast range of diseases," said Thompson. "Once we identify the gene, we can target it with a drug to reduce the risk of disease. People also can take preventive steps through exercise, diet and mental stimulation to erase the effects of a bad gene."



In an intriguing twist, Project ENIGMA investigators also discovered genes that explain individual differences in intelligence. They found that a variant in a gene called HMGA2 affected brain size, as well as a person's intelligence.



DNA comprises four bases: A (adenine), C (cytosine), T (thymine) and G (guanine). People whose HMGA2 gene held a letter "C" instead of a "T" at a specific location on the gene possessed larger brains and scored more highly on standardized IQ tests.



"This is a really exciting discovery, that a single letter change leads to a bigger brain," Thompson said. "We found fairly unequivocal proof supporting a genetic link to brain function and intelligence. For the first time, we have watertight evidence of how these genes affect the brain. This supplies us with new leads on how to mediate their impact."



Because disorders like Alzheimer's, autism and schizophrenia disrupt the brain's circuitry, Project ENIGMA will next search for genes that influence how the brain is wired. Thompson and his colleagues will use diffusion imaging, a new type of brain scan that maps the communication pathways between cells in the living brain.



Project ENIGMA received funding from hundreds of federal and private agencies around the world. Thompson's UCLA co-authors included first author Jason Stein, Derrek Hibar, Rudy Senstad, Neda Jahanshad, Arthur Toga, Rita Cantor, Dr. Nelson Freimer, Roel Ophoff, Kristy Hwang, Dr. Liana Apostolova and Dr. Giovanni Coppola.



The UCLA Department of Neurology, with over 100 faculty members, encompasses more than 20 disease-related research programs, along with large clinical and teaching programs. These programs cover brain mapping and neuroimaging, movement disorders, Alzheimer's disease, multiple sclerosis, neurogenetics, nerve and muscle disorders, epilepsy, neuro-oncology, neurotology, neuropsychology, headaches and migraines, neurorehabilitation, and neurovascular disorders. The department ranks in the top two among its peers nationwide in National Institutes of Health funding.

 

[Intellau_Celistic]

The Slit-Eye Pass:

 

[Postmaxxercel50k]

Nigger faggot

 

[Intellau_Celistic]

Mother:

Hey! Two CCs...!

Oh wait:

ALFA Allele Frequency
The ALFA project provide aggregate allele frequency from dbGaP. More information is available on the project page including descriptions, data access, and terms of use.


Release Version: 20201027095038

Search:

Population	Group	Sample Size	Ref Allele	Alt Allele

Population	Group	Sample Size	Ref Allele	Alt Allele
Total	Global	7920	G=0.3301	A=0.0000, C=0.6699, T=0.0000
European	Sub	7116	G=0.2919	A=0.0000, C=0.7081, T=0.0000
African	Sub	510	G=0.820	A=0.000, C=0.180, T=0.000
African Others	Sub	22	G=0.77	A=0.00, C=0.23, T=0.00
African American	Sub	488	G=0.822	A=0.000, C=0.178, T=0.000
Asian	Sub	4	G=0.0	A=0.0, C=1.0, T=0.0
East Asian	Sub	2	G=0.0	A=0.0, C=1.0, T=0.0

There we go.

Myself:

GWAS of 126,559 Individuals Identifies Genetic Variants Associated with Educational Attainment

A genome-wide association study of educational attainment was conducted in a discovery sample of 101,069 individuals and a replication sample of 25,490. Three independent SNPs are genome-wide significant (rs9320913, rs11584700, rs4851266), and all three ...

www.ncbi.nlm.nih.gov

 

[Intellau_Celistic]

Mathematics ability is a complex cognitive trait with polygenic heritability. Genome-wide association study (GWAS) has been an effective approach to investigate genetic components underlying mathematic ability. Although previous studies reported several candidate genetic variants, none of them exceeded genome-wide significant threshold in general populations. Herein, we performed GWAS in Chinese elementary school students to identify potential genetic variants associated with mathematics ability. The discovery stage included 494 and 504 individuals from two independent cohorts respectively. The replication stage included another cohort of 599 individuals. In total, 28 of 81 candidate SNPs that met validation criteria were further replicated. Combined meta-analysis of three cohorts identified four SNPs (rs1012694, rs11743006, rs17778739 and rs17777541) of SPOCK1 gene showing association with mathematics ability (minimum p value 5.67 × 10−10, maximum β −2.43)

ALFA Allele Frequency
The ALFA project provide aggregate allele frequency from dbGaP. More information is available on the project page including descriptions, data access, and terms of use.


Release Version: 20201027095038

Search:

Population	Group	Sample Size	Ref Allele	Alt Allele

Population	Group	Sample Size	Ref Allele	Alt Allele
Total	Global	199264	C=0.867332	A=0.132668, G=0.000000
European	Sub	169786	C=0.860466	A=0.139534, G=0.000000
African	Sub	9560	C=0.9727	A=0.0273, G=0.0000
African Others	Sub	344	C=0.991	A=0.009, G=0.000
African American	Sub	9216	C=0.9720	A=0.0280, G=0.0000
Asian	Sub	646	C=0.780	A=0.220, G=0.000
East Asian	Sub	514	C=0.798	A=0.202, G=0.000

 

[Shaktiman]

What is the difference between the BWC fetish and BBC fetish? The former is held by a far larger pool of women, along with white males being seen as actual human beings with desired characteristics - a real dating prospect (granted that you meet a certain looks threshold, yes). BBC is a one and done thing - if you have one and have the typical Tyrone phenotype (or are NT enough to be able to attract the attention of the BBC obsessed). It seems white males loves to skirt by the JBW meme (which does hold truth if you meet the requirements - which are not as high as those needed for a BBC male) by pushing this inane idea. Other ethnics are just weird and cannot get BBC out of their minds - must be infuriating for them.

Womem crave both BBC and BWC with the former by lighter woman and the latter by darker women