Theory Autism & Schizophrenia: Genetic Associations

[Intellau_Celistic]

 

[trognarukk]

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On a scale from 1-10 how many thoughts go throgh your mind right now?

 

[Intellau_Celistic]

https://journals.sagepub.com/doi/full/10.1177/03000605221138492

 

[Bianor]

On a scale from 1-10 how many thoughts go throgh your mind right now?

How does that work

 

[Intellau_Celistic]

 

[Intellau_Celistic]

Archived nicely.

 

[Intellau_Celistic]

Archived.

 

[Intellau_Celistic]

How does that work

It isn't clear-cut.

 

[Intellau_Celistic]

Archived nicely.

 

[Intellau_Celistic]

(Maternal)

 

[kay']

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(Maternal)

bro

 

[Intellau_Celistic]

The color scheme implies systemization.

C1:

The hypersystemizing theory of autism suggests that autistic individuals, on average, have superior attention to detail, and a stronger drive to systemize. Systemizing involves identifying input-operation-output relationships. Here, we report the results of genome-wide association studies (GWAS) of systemizing measured using the Systemizing Quotient - Revised in n = 51,564 individuals. We identify three genome-wide significant loci: Two of these were significant in the non-stratified GWAS: rs4146336 on chromosome 3 (P = 2.58×10−8) and rs1559586 on chromosome 18 (P = 4.78×10−8). In addition, we also identified a significant locus in the males-only GWAS (rs8005092 on chromosome 14, P = 3.74×10−8). We find that 12%± 1.2 of the variance in systemizing is captured by SNPs (P=1.2×10−20). We identify a positive genetic correlation between autism and systemizing (rg = 0.26±0.06; P = 3.35×10−5), which is independent of genetic contribution to educational attainment. We further demonstrate that genetic risk for autism from systemizing is genetically distinct from genetic risk emerging from social autistic traits, suggesting distinct shared genetics between autism and social and non-social traits. Our results highlight the importance of considering both social and non-social autistic traits in elucidating the genetic architecture of autism.

Systemizing is genetically correlated with autism and is genetically distinct from social autistic traits

The hypersystemizing theory of autism suggests that autistic individuals, on average, have superior attention to detail, and a stronger drive to systemize. Systemizing involves identifying input-operation-output relationships. Here, we report the results of genome-wide association studies (GWAS)...

www.biorxiv.org

We'll review it again in a few days.

 

[kay']

The color scheme implies systemization.

C1:

Systemizing is genetically correlated with autism and is genetically distinct from social autistic traits

The hypersystemizing theory of autism suggests that autistic individuals, on average, have superior attention to detail, and a stronger drive to systemize. Systemizing involves identifying input-operation-output relationships. Here, we report the results of genome-wide association studies (GWAS)...

www.biorxiv.org

We'll review it again in a few days.

Dnr

 

[Intellau_Celistic]

We review another form of possible implied systemizing.

C2:

In 2003, we proposed the hypersystemizing theory of autism. The theory proposes that the human mind possesses a systemizing mechanism (SM) that helps identify lawful regularities (often causal) that govern the input-operation-output workings of a system. The SM can be tuned to different levels, from low to high, with a normal distribution of individual differences in how strongly people search for such input-operation-out-put regularities in any data that is systemizable. Evidence suggests that people with autism are on average hypersystemizers, scoring higher than average on the systemizing quotient and on performance tests of systemizing. In this article, we consider the neural basis behind the SM, since there has been little consideration of the brain basis of systemizing. Finally, we discuss directions for future work in this field.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5789212/

 

[Intellau_Celistic]

Another systemizing review is offered for the thread.

C3:

 

[Intellau_Celistic]

 

[Old Ironsides]

7-11.

 

[Old Ironsides]

Bitch.

 

[Intellau_Celistic]

I see.

 

[Intellau_Celistic]

 

[Intellau_Celistic]

 

[Sergeant Kelly]

Why were you putting random snippets of roblox forum conversations under various posts for some time? This always puzzled me.

 

[WhitePilledRage]

The two conditions known as Autistic Spectrum Disorder(ASD) and Schizophrenic Spectrum Disorder(SSD) are closely associated, genetically-speaking.

ASD:

Autism Spectrum Disorder disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

www.malacards.org

SSD:

https://www.malacards.org/card/schizophrenia?search=Schizophrenia

ASD and SSD are both known to cause cognitive impairments and sensory problems/psychosis...

I'll focus on Processing Speed for this thread:

IQ Part 5: Processing Speed | EdPsyched

Welcome to the final installment of my deep dive into the IQ. We have already looked at the first four components: Verbal Comprehension, Visual Spatial, Fluid Reasoning and Working Memory. Today’s post will examine Processing Speed. As a reminder, I’ve been using the WISC-V for the basis of...

edpsyched.com

With our introduction to the PSI, let's begin:

Longitudinal processing speed impairments in males with autism and the effects of white matter microstructure - PubMed

The present study used an accelerated longitudinal design to examine group differences and age-related changes in processing speed in 81 individuals with autism spectrum disorder (ASD) compared to 56 age-matched individuals with typical development (ages 6-39 years). Processing speed was...

pubmed.ncbi.nlm.nih.gov

Cognitive Deficits in Psychotic Disorders: A Lifespan Perspective - PubMed

Individuals with disorders that include psychotic symptoms (i.e. psychotic disorders) experience broad cognitive impairments in the chronic state, indicating a dimension of abnormality associated with the experience of psychosis. These impairments negatively impact functional outcome...

pubmed.ncbi.nlm.nih.gov

ASD and SSD affect cognition and processing speed, as indicated above.

Below is an example of my own genetic results:

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The Psychiatric Risk Gene Transcription Factor 4 (TCF4) Regulates Neurodevelopmental Pathways Associated With Schizophrenia, Autism, and Intellectual Disability

AbstractBackground. Common genetic variants in and around the gene encoding transcription factor 4 (TCF4) are associated with an increased risk of schizoph

academic.oup.com

So they're basically retarded?

 

[Intellau_Celistic]

So they're basically retarded?

Yes