Weed
ded srs
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Weirdest posts I've ever seen ngl
Morf12 said:Whats the context to the garbage he keeps spamming? Not everyone lived on that garbage of site called lookism.net
incelkingkong said:You're both competing pretty well tbh.
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Whats the context to the garbage he keeps spamming? Not everyone lived on that garbage of site called lookism.net
1000Genomes_30x | Global | Study-wide | 6404 | A=0.8599 | C=0.1401 |
1000Genomes_30x | African | Sub | 1786 | A=0.7447 | C=0.2553 |
1000Genomes_30x | Europe | Sub | 1266 | A=0.9447 | C=0.0553 |
1000Genomes_30x | South Asian | Sub | 1202 | A=0.7413 | C=0.2587 |
1000Genomes_30x | East Asian | Sub | 1170 | A=0.9966 | C=0.0034 |
1000Genomes_30x | American | Sub | 980 | A=0.943 | C=0.057 |
Results
Carriers of the risk allele had a statistically significant lower performance in the cognitive domain of Reasoning/Problem-Solving compared to non-carriers (F1,172 = 4.4, p = .038). There were no significant genotype effects on the other cognitive domains or general cognition. This effect on the Reasoning/Problem-Solving domain remained significant even when controlling for IQ (F1,172 = 4.3, p = .039).
Conclusions
rs9960767 (C) of TCF4 appears to be associated with neurocognitive deficits in the Reasoning/Problem-Solving cognitive domain, in patients with FEP. A confirmation of this finding in a larger sample and including other TCF4 polymorphisms will be needed to gain further validity of this result.
In both samples, PPI was strongly decreased in carriers of the schizophrenia risk allele C of the TCF4 gene (meta-analysis across both samples: p = 0.00002), whereas startle reactivity and habituation were unaffected by TCF4 genotype. Sensorimotor gating is modulated by TCF4 genotype, indicating an influential role of TCF4 gene variations in the development of early information-processing deficits in schizophrenia.