JFL at you if you're a gymcel and you think your effort is worth anything at all, while you're spending hours in the gym blowing yourself out and constantly monitoring your diet, keeping track of your weight and collapsing on the bed sore as all hell and riddled with fatigue, chad eats whatever he wants, runs around and does a few pushups and looks like a male model / bodybuilder without even trying or even feeling the slightest bit tired, in fact, he was LITERALLY BORN with 6-pack abs.
"Myostatin-related muscle hypertrophy (or myotonic hypertrophy) is a rare genetic condition characterized by reduced body fat and increased skeletal muscle size. Affected individuals have up to twice the usual amount of muscle mass in their bodies. They also tend to have increased muscle strength. Myostatin-related muscle hypertrophy is not known to cause medical problems, and affected individuals are intellectually normal. The prevalence of this condition is unknown.
Mutations in the MSTN gene cause myostatin-related muscle hypertrophy. The MSTN gene provides instructions for making a protein called myostatin, which is active in muscles used for movement (skeletal muscles) both before and after birth. This protein normally restrains muscle growth, ensuring that muscles do not grow too large. Mutations that reduce the production of functional myostatin lead to an overgrowth of muscle tissue. Myostatin-related muscle hypertrophy has a pattern of inheritance known as incomplete autosomal dominance. People with a mutation in both copies of the gene in each cell (homozygotes) have significantly increased muscle mass and strength. People with a mutation in one copy of the MSTN gene in each cell (heterozygotes) also have increased muscle bulk, but to a lesser degree."
-source: https://en.m.wikipedia.org/wiki/Myostatin-related_muscle_hypertrophy
"Genetic factors explain about half of the total variance of lean body mass in this cohort of female postmenopausal, Caucasian twins, which is consistent with previous family studies.7,24,25 These studies, which used DXA or underwater weighing to estimate lean body mass, have shown significant familial correlations for lean mass, suggesting a genetic component but without directly estimating its size. Our estimate is, however, smaller than that obtained by the authors of an Australian twin study, also using DXA, which estimated that the genetic component accounts for 80% of total variance "
-source: https://onlinelibrary.wiley.com/doi/full/10.1359/jbmr.1997.12.12.2076
"We have identified 16 loci associated with maximal hand grip strength at genome-wide significance. A number of the lead variants were located within or close to genes implicated in structure and function of skeletal muscle fibres, neuronal maintenance and signal transduction in the central and peripheral nervous systems. Partitioned heritability analyses indicated significant tissue-specific enrichment of skeletal muscle, CNS, connective tissue and bone in the genome-wide grip strength results. We observed evidence of shared genetic aetiology between lean mass and grip strength, while pathway analyses indicated a role for genes involved in regulation of protein catabolism in the aetiology of grip strength."
-source: https://www.nature.com/articles/ncomms16015#discussion
"Some of the 16 locations, or "loci," are situated within or near genes already known to be important to the biology of muscles.
These genes include ACTG1, which is related to skeletal muscle fibre structure and function, and three genes called PEX14, TGFA, and SYT1, which are all important for muscle cell communication with the nervous system.
Variants of three genes identified - namely, PEX14, LRPPRC, and KANSL1 - are also known to be involved in severe muscle conditions that are caused by a single faulty gene."
-source: https://www.medicalnewstoday.com/articles/318412.php
A single gene is the difference between a prosperous life or a painful death
"Myostatin-related muscle hypertrophy (or myotonic hypertrophy) is a rare genetic condition characterized by reduced body fat and increased skeletal muscle size. Affected individuals have up to twice the usual amount of muscle mass in their bodies. They also tend to have increased muscle strength. Myostatin-related muscle hypertrophy is not known to cause medical problems, and affected individuals are intellectually normal. The prevalence of this condition is unknown.
Mutations in the MSTN gene cause myostatin-related muscle hypertrophy. The MSTN gene provides instructions for making a protein called myostatin, which is active in muscles used for movement (skeletal muscles) both before and after birth. This protein normally restrains muscle growth, ensuring that muscles do not grow too large. Mutations that reduce the production of functional myostatin lead to an overgrowth of muscle tissue. Myostatin-related muscle hypertrophy has a pattern of inheritance known as incomplete autosomal dominance. People with a mutation in both copies of the gene in each cell (homozygotes) have significantly increased muscle mass and strength. People with a mutation in one copy of the MSTN gene in each cell (heterozygotes) also have increased muscle bulk, but to a lesser degree."
-source: https://en.m.wikipedia.org/wiki/Myostatin-related_muscle_hypertrophy
"Genetic factors explain about half of the total variance of lean body mass in this cohort of female postmenopausal, Caucasian twins, which is consistent with previous family studies.7,24,25 These studies, which used DXA or underwater weighing to estimate lean body mass, have shown significant familial correlations for lean mass, suggesting a genetic component but without directly estimating its size. Our estimate is, however, smaller than that obtained by the authors of an Australian twin study, also using DXA, which estimated that the genetic component accounts for 80% of total variance "
-source: https://onlinelibrary.wiley.com/doi/full/10.1359/jbmr.1997.12.12.2076
"We have identified 16 loci associated with maximal hand grip strength at genome-wide significance. A number of the lead variants were located within or close to genes implicated in structure and function of skeletal muscle fibres, neuronal maintenance and signal transduction in the central and peripheral nervous systems. Partitioned heritability analyses indicated significant tissue-specific enrichment of skeletal muscle, CNS, connective tissue and bone in the genome-wide grip strength results. We observed evidence of shared genetic aetiology between lean mass and grip strength, while pathway analyses indicated a role for genes involved in regulation of protein catabolism in the aetiology of grip strength."
-source: https://www.nature.com/articles/ncomms16015#discussion
"Some of the 16 locations, or "loci," are situated within or near genes already known to be important to the biology of muscles.
These genes include ACTG1, which is related to skeletal muscle fibre structure and function, and three genes called PEX14, TGFA, and SYT1, which are all important for muscle cell communication with the nervous system.
Variants of three genes identified - namely, PEX14, LRPPRC, and KANSL1 - are also known to be involved in severe muscle conditions that are caused by a single faulty gene."
-source: https://www.medicalnewstoday.com/articles/318412.php
A single gene is the difference between a prosperous life or a painful death
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