I think it gradually gets worse as the day gets on. Every morning is like a new rebirth, and every evening is the culmination of stress and suffering, the point in which the body reaches its anti-climatic point of suffering and has to momentary depart from existence, so it could be reborn anew the following morning.
When you wake up the very first thing that you notice is that your ever-nonexistent girlfriend isn't laying next to you, - even knowing the fact that you have never(in this iteration of life) had a girlfriend and technically "you can't miss something you've never had." It is most certainly the very first thing you miss. That's partly due to the fact that if the stream of life were to be reduced into its essence from the ephemeral/transient(momentary) forms that it takes in the variety of the life forms that we see, - we would see that the "abstract stream steam of life" that lies in the "shadowland of the preexistence of time itself" consists of the positive(male) and the negative(female) elements that are closely intertwined with one another, in this ceaseless flow, which is the "stream of life", and only through the intimate union(intimate intertwining) of these opposing two elements can the stream of life continue .
So if the individual, who is only one element of this grand stream of life, is for whatever reason detached from the opposing element, the flow of life for that individual comes to a halt, - the "freezing" of the flow of life, manifests itself in various disorders, complexes, and various feelings of impotence and despair... along with the primordial urge to terminate one's own existence.