I dunno about sadness for you, but maybe you can relate to the feeling of having the only person you know better than yourself, your twin, holding you down by the throat and trying to bash your skull in with an iron door jamb because you stood up to his girlfriend who was physically / mentally abusing him with her toxic personality. Resulting argument / fight involving your twin, (Who you loved.) At this point, you don't believe in hurting family, so you just let him try to kill you. Fight ends he gets pulled off you. You're ok but it turns into a screaming match. He brings up that you're subhuman trash unfit to be called family, and if you were actually to get hit by a bus and die then the family would be better off. Have your mother in the room, look her in the eyes as your brother says this and she breaks eye contact. She can't even deny what your twin said.
Its just a kind of hollowing experience. Having had your eyes almost dug out to the point where there were cuts and bruises from where your own twin tried to push his thumbs in. It's not really depressing unless you can experience the sense of betrayal and confusion that someone you love is trying to kill you.
Eh, going further into detail is more rageful than sadness. That's probably one of the stronger moments I've had that didn't involve a girl. My family confirming my existence to not matter, as though I didn't know.
My big getting cucked moments are more rageful and sui than sadness. And my depression is too TLDR to put in a post.