Life, even existence has no meaning. At least to our understanding without any religious/spiritual mumbo-jumbo. So we find our own purpose, our own niche to fill, which is determined by our peers. Without peers, we are lonely and we fight to find purpose. Eventually even copes becomes useless, the effort to find others will increase including the desire. If that fails, the copes and fetishes you develop will be taken into more extremes. If the former wins out, and you'll be paired with peers how can you tell if they're really your friends? Even if they seem to genuinely care for you, you cannot make the connection since your mind is dull and faded. If the latter fails, your own demise by your hand or another.