![night-20](/data/avatars/m/43/43120.jpg?1653323239)
night-20
Recruit
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- Joined
- May 23, 2022
- Posts
- 488
One of my fears is getting a low score from an iq test.
No, I am just not attractive
Actually, most of the autists have sub 100 iqno i am an autist
we usually get high iqs
i am always thinking
Cognitive Processing Speed Is Strongly Related to Driving Skills, Financial Abilities, and Other Instrumental Activities of Daily Living in Persons With Mild Cognitive Impairment and Mild Dementia
A growing body of evidence demonstrates that persons with mild cognitive impairment (MCI) have difficulties or declines in performing everyday tasks such as handling finances, driving, and other instrumental activities of daily living (IADLs) (1–4). While it has been established in cognitively normal older adults that speed in processing visual stimuli is key for the timely and successful performance of these activities (5–7), the link between cognitive processing speed and IADL function has been examined less extensively in persons on the continuum of MCI due to Alzheimer’s disease (AD) (8,9), in whom episodic memory is generally the hallmark deficit (10). In particular, the relationship of processing speed to everyday abilities in MCI and very mild dementia has not been examined while accounting for potential contributions of genetic and neuroimaging biomarkers that represent risk for AD and vascular cognitive impairment. We can gain additional insight by including the vantage points offered by this broader perspective.
Sensorimotor gating is the process by which one filters out relevant from irrelevant information, a process that is deficient in multiple neuropsychiatric disorders including TS (Castellanos et al., 1996). Prepulse inhibition (PPI) is a measure of sensorimotor gating, in which response, or startle, to a stimulus (pulse) is diminished when the stimulus is preceded by a smaller stimulus (prepulse) (Swerdlow, 2013; Swerdlow and Sutherland, 2005). Disruption of this normal inhibition of startle is consistent with deficient sensorimotor gating. Structures relevant to PPI include the frontal dopaminergic pathways and striatum (Swerdlow et al., 2001). Pharmacological interventions that restore normal PPI typically have good predictive validity for efficacy in multiple neuropsychiatric disorders including TS
Results: Tcf4 transgenic mice display profound deficits in contextual and cued fear conditioning and sensorimotor gating. Furthermore, we show that TCF4 interacts with the neurogenic bHLH factors NEUROD and NDRF in vivo. Molecular analyses revealed the dynamic circadian deregulation of neuronal bHLH factors in the adult hippocampus.
Conclusions: We conclude that TCF4 likely acts in concert with other neuronal bHLH transcription factors contributing to higher-order cognitive processing. Moderate transcriptional deregulation of Tcf4 in the brain interferes with cognitive functions and might alter circadian processes in mice. These observations provide insight for the first time into the physiological function of TCF4 in the adult brain and its possible contributions to neuropsychiatric disease conditions.
we usually get high iqs
i am always thinking
yes MOST but i am not mostActually, most of the autists have sub 100 iq![]()